公开(公告)号：US20240350456A1

公开(公告)日：2024-10-24

申请号：US18631821

申请日：2024-04-10

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

发明人： Ronaldo P. Ferraris ,  Nan Gao ,  Wei Vivian Li

IPC分类号： A61K31/4045 ,  A61K31/047 ,  A61K31/132 ,  A61K31/145 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/20 ,  A61K31/205 ,  A61K31/216 ,  A61K31/221 ,  A61K31/223 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4015 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4172 ,  A61K31/4188 ,  A61K31/455 ,  A61K31/51 ,  A61K31/513 ,  A61K31/522 ,  A61K31/609 ,  A61K31/66 ,  A61K31/685 ,  A61K31/7012 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61P1/12 ,  C12Q1/6883 ,  G01N33/68

CPC分类号： A61K31/4045 ,  A61K31/047 ,  A61K31/132 ,  A61K31/145 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/20 ,  A61K31/205 ,  A61K31/216 ,  A61K31/221 ,  A61K31/223 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4015 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4172 ,  A61K31/4188 ,  A61K31/455 ,  A61K31/51 ,  A61K31/513 ,  A61K31/522 ,  A61K31/609 ,  A61K31/66 ,  A61K31/685 ,  A61K31/7012 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61P1/12 ,  C12Q1/6883 ,  G01N33/6893 ,  C12Q2600/158 ,  G01N2800/06

摘要： Compositions and methods useful for the diagnosis and treatment of leaky gut syndrome and IBD including Crohn's disease are disclosed.

公开(公告)号：US20240302384A1

公开(公告)日：2024-09-12

申请号：US18547759

申请日：2022-03-03

申请人： APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS ) ,  UNIVERSITE PARIS ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ) ,  IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

发明人： Yoram BOUHNIK ,  Alexandre NUZZO ,  Olivier CORCOS ,  Marc-Emmanuel DUMAS ,  Antonis MYRIDAKIS ,  Dominique GAUGUIER

IPC分类号： G01N33/68 ,  G01N33/53 ,  G01N33/92

CPC分类号： G01N33/6893 ,  G01N33/5308 ,  G01N33/92 ,  G01N2570/00 ,  G01N2800/06 ,  G01N2800/7019

摘要： A metabolomic signature of acute mesenteric ischemia (AMI) and the determination thereof in a method for identifying a subject suffering or being at risk of suffering from AMI. Also, a kit that includes elements for determining the metabolomic signature of AMI and implementing the method for identifying a subject suffering or being at risk of suffering from AMI.

公开(公告)号：US20230375534A1

公开(公告)日：2023-11-23

申请号：US18247865

申请日：2021-10-05

申请人： VIB VZW ,  KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D ,  THE UNIVERSITY OF BRISTOL

发明人： Jeroen Raes ,  Sebastian Proost ,  Gwen Falony ,  Sara Manuel Araujo Vieira Da Silva ,  Nicholas John Timpson ,  David Allen Hughes

IPC分类号： G01N33/53

CPC分类号： G01N33/5308 ,  G01N2800/06

摘要： The disclosure relates to the field of the human gut microbiome, more particularly, to its effect on health and disease. Provided herein are means and methods to diagnose and treat or reduce the severity of gut flora dysbiosis as well as of gastro-intestinal inflammation and inflammation-associated disorders or conditions in a subject in need thereof.

公开(公告)号：US11679186B2

公开(公告)日：2023-06-20

申请号：US17201569

申请日：2021-03-15

申请人： Medtronic, Inc.

发明人： Martin T. Gerber ,  Christopher M. Hobot

IPC分类号： A61M1/28 ,  A61M1/16 ,  A61B5/145 ,  A61B5/00 ,  G01N21/78 ,  G01N21/80 ,  G01N21/77

CPC分类号： A61M1/28 ,  A61B5/14507 ,  A61B5/6866 ,  A61M1/1601 ,  A61M1/1609 ,  A61M1/287 ,  A61M2205/3306 ,  A61M2205/3324 ,  A61M2205/50 ,  A61M2205/75 ,  G01N21/78 ,  G01N21/80 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  G01N2800/06

摘要： The invention relates to a testing system and related methods for detecting peritonitis or infection in peritoneal dialysate removed from a patient. The testing system can include a fluid sensor apparatus in a fluid line of a peritoneal dialysis cycler through which spent peritoneal dialysate can be pumped. The fluid sensor apparatus can detect one or more markers associated with peritonitis or infection.

公开(公告)号：US20180356413A1

公开(公告)日：2018-12-13

申请号：US15778163

申请日：2016-11-23

申请人： MOLOGIC LIMITED

发明人： Gita Parekh

IPC分类号： G01N33/543 ,  G01N33/573 ,  G01N33/68 ,  B01L3/00 ,  A61M1/28

CPC分类号： G01N33/54306 ,  A61M1/1654 ,  A61M1/287 ,  A61M2210/0625 ,  A61M2210/1017 ,  A61M2210/12 ,  B01L3/5023 ,  B01L2200/026 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2400/0406 ,  G01N33/573 ,  G01N33/6869 ,  G01N2333/5412 ,  G01N2333/96494 ,  G01N2800/06 ,  G01N2800/52

摘要： A diagnostic test apparatus comprises: an elongate housing defining a test strip holder containing a lateral flow test strip; a fluid sampling chamber provided with an opening connecting the fluid sampling chamber with the test strip holder; a viewing window in the elongate housing allowing reading of one or more portions of the lateral flow test strip; and a connector configured to couple the diagnostic test apparatus to a bulk source of fluid. The apparatus may be included in a kit of parts. The apparatus is useful for detecting peritonitis. The bulk source of fluid may be peritoneal dialysate. Various markers may be determined in the bulk source of fluid such as MMP8, IL-6, HNE, MMP2, MMP9, TIMP1, TIMP2, NGAL, A1AT, desmosine, fibrinogen, IL-8, calprotectin, fMLP, IL1b, cystatin C, HSA, RBP4, SPD, MPO, sICAM and TNFa. Detection of the markers to indicate peritonitis may also inform treatment choices.

公开(公告)号：US20180313849A1

公开(公告)日：2018-11-01

申请号：US16011043

申请日：2018-06-18

申请人： Kenneth Davin Fine

发明人： Kenneth Davin Fine

IPC分类号： G01N33/68

CPC分类号： G01N33/6854 ,  G01N33/6893 ,  G01N2800/06 ,  G01N2800/24

摘要： In various implementations, a noninvasive, veterinary diagnostic test may be utilized to identify one or more immunologic food sensitivities. A fecal sample may be obtained. The veterinary diagnostic test may be performed on the obtained fecal sample. One or more immunologic food sensitivities may be identified based on the veterinary diagnostic test.

公开(公告)号：US20180259503A1

公开(公告)日：2018-09-13

申请号：US15981244

申请日：2018-05-16

申请人： BIOGAIA AB

发明人： Eamonn Conolly ,  Wolfgang Kunze ,  John Bienenstock

IPC分类号： G01N33/50 ,  G01N33/68 ,  A61K45/06 ,  A61K35/74

CPC分类号： G01N33/5041 ,  A61K35/74 ,  A61K45/06 ,  A61K2035/11 ,  G01N33/6872 ,  G01N33/6893 ,  G01N2333/705 ,  G01N2800/06

摘要： The present embodiments relate to selection of agents effective in reducing or preventing gastrointestinal pain in a subject. Such an agent is selected and identified if it is capable of reducing spontaneous and/or induced transient receptor potential vanilloid 1 (TRPV1) activation.

公开(公告)号：US20180135127A1

公开(公告)日：2018-05-17

申请号：US15521224

申请日：2015-10-22

申请人： The George Washington University a Congressionally Chartered Not-for-Profit Corporation

发明人： Lakhmir S. Chawla ,  Timothy A. McCaffrey

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G01N33/566 ,  G01N33/6893 ,  G01N33/84 ,  G01N2500/04 ,  G01N2800/06 ,  G01N2800/56

摘要： The invention relates to methods and kits for diagnosing and/or treating appendicitis in a subject, comprising obtaining a biological sample from said subject; detecting RNA expression levels of at least three or more biomarkers in the biological sample and comparing the expression levels of said at least three or more biomarkers to a control sample wherein an increase or decrease in the level of expression of said at least three or more biomarkers as compared to the control sample is indicative of appendicitis.

公开(公告)号：US09952223B2

公开(公告)日：2018-04-24

申请号：US15609959

申请日：2017-05-31

申请人： Cedars-Sinai Medical Center

发明人： Mark Pimentel ,  Christopher Chang

IPC分类号： G01N33/68 ,  A61K38/17

CPC分类号： G01N33/6887 ,  A61K38/1709 ,  G01N33/564 ,  G01N2333/4703 ,  G01N2333/705 ,  G01N2800/06 ,  G01N2800/065 ,  G01N2800/2842

摘要： Described herein are methods and systems for the detection of anti-vinculin antibodies, for determining a presence or likely presence of a gastrointestinal motility disorder, bladder motility disorder, or fibromyalgia. Further provided are methods of selecting and/or administering a therapy based on the presence or absence of anti-vinculin antibodies.

公开(公告)号：US20180100200A1

公开(公告)日：2018-04-12

申请号：US15809162

申请日：2017-11-10

申请人： CLINICAL GENOMICS PTY. LTD. ,  COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

发明人： Lawrence Charles LAPOINTE ,  Robert DUNNE ,  Graeme P. YOUNG ,  Trevor John LOCKETT ,  William J. WILSON

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57446 ,  G01N2800/06

摘要： The present invention relates generally to nucleic acid molecules, the RNA and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the expression profile of one or more nucleic acid molecule markers.