公开(公告)号：US07037932B2

公开(公告)日：2006-05-02

申请号：US10476137

申请日：2002-05-06

申请人： Peter Gallagher ,  Richard Edmund Rathmell ,  Maria Ann Fagan

发明人： Peter Gallagher ,  Richard Edmund Rathmell ,  Maria Ann Fagan

IPC分类号： A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  C07D209/04 ,  C07D333/52

CPC分类号： C07D333/54 ,  C07D209/08 ,  C07D307/79 ,  C07D333/62 ,  C07D333/68

摘要： There is provided a heretoaryloxy 3-substituted propanamine compound of formula (I): wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents selected from halo, C1–C4 alkyl and C1–C4 alkoxy, and thienyl optionally substituted with up to 3 substituents selected from halo and C1–C4 alkyl; Y is selected from benzothienyl, indolyl and benzofuranyl, optionally substituted with up to 5 substituents selected from halo, C1–C4 alkyl, C1–C4 alkoxy, nitro, acetyl and cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C1–C4 alkyl; R1 and R2 are each independently H or C1–C4 alkyl; and pharmaceutically acceptable salts thereof.

摘要翻译： 提供式（I）的异烟酰基-3-取代的丙胺化合物：其中A选自-O-和-S-; X选自任选被至多5个选自卤素，C 1 -C 4烷基和C 1 -C 4烷基的取代基取代的苯基 > 4个烷氧基，任选被至多3个选自卤素和C 1 -C 4烷基的取代基取代的噻吩基; Y选自苯并噻吩基，吲哚基和苯并呋喃基，任选被至多5个选自卤素，C 1 -C 4烷基，C 1〜 -C≡4烷氧基，硝基，乙酰基和氰基; 当Y是吲哚基时，它可以被选自C 1 -C 4烷基的N-取代基取代或进一步取代; R 1和R 2各自独立地为H或C 1 -C 4烷基; 及其药学上可接受的盐。