公开(公告)号：US20240279173A1

公开(公告)日：2024-08-22

申请号：US18367760

申请日：2023-09-13

申请人： Queen's University at Kingston

发明人： Donald Andrew Cameron ,  Martin Petkovich ,  Uttam Saha

IPC分类号： C07D209/08 ,  A61K9/00 ,  A61K45/06 ,  A61P17/10 ,  C07C59/84 ,  C07D307/79 ,  C07D311/58 ,  C07D407/04 ,  C07F5/02

CPC分类号： C07D209/08 ,  A61P17/10 ,  C07C59/84 ,  C07D307/79 ,  C07D311/58 ,  C07D407/04 ,  C07F5/025 ,  A61K9/0014 ,  A61K45/06

摘要： Compounds that are inhibitors of retinoic acid inducible P450 (CYP26) enzymes. The compounds have retinoid activity, are resistant to CYP26-mediated catabolismact as inhibitors of CYP26B1, and are used for treating diseases that are responsive to retinoids.

公开(公告)号：US12065419B2

公开(公告)日：2024-08-20

申请号：US17052937

申请日：2019-04-30

申请人： Semiconductor Energy Laboratory Co., Ltd.

发明人： Kyoko Takeda ,  Hiroshi Kadoma ,  Yusuke Takita ,  Tsunenori Suzuki ,  Satoshi Seo

IPC分类号： C07D307/79 ,  H10K50/15 ,  H10K85/60

CPC分类号： C07D307/79 ,  H10K85/636 ,  H10K85/6574 ,  H10K50/15

摘要： A novel organic compound is provided. Alternatively, an organic compound that exhibits light emission with favorable chromaticity is provided. Alternatively, an organic compound that exhibits blue light emission with favorable chromaticity is provided. Alternatively, a light-emitting device with favorable emission efficiency is provided. Alternatively, an organic compound having a high carrier-transport property is provided. Alternatively, an organic compound with favorable reliability is provided. An organic compound having at least one amino group in which any one of a substituted or unsubstituted dibenzofuranyl group, a substituted or unsubstituted dibenzothiophenyl group, and a substituted or unsubstituted carbazolyl group is bonded to any one of a substituted or unsubstituted naphthobisbenzofuran skeleton, a substituted or unsubstituted naphthobisbenzothiophene skeleton, and a substituted or unsubstituted naphthobenzothienobenzofuran skeleton is provided.

公开(公告)号：US12020872B2

公开(公告)日：2024-06-25

申请号：US18156925

申请日：2023-01-19

申请人： AMBIENT PHOTONICS, INC.

发明人： John C. Warner

IPC分类号： H01G9/20 ,  C07D307/79 ,  C07D307/81 ,  C09B23/10 ,  C09B23/14 ,  C09B57/00 ,  H10K85/60 ,  H10K30/15 ,  H10K102/10

CPC分类号： H01G9/2059 ,  C07D307/79 ,  C07D307/81 ,  C09B23/105 ,  C09B23/148 ,  C09B57/008 ,  H10K85/636 ,  H10K30/151 ,  H10K85/6574 ,  H10K2102/102 ,  Y02E10/542 ,  Y02E10/549 ,  Y02P70/50

摘要： The present application discloses stilbene derivative compounds and phenylbenzofuran compositions, useful in the manufacture of dye-sensitized solar cells and other similar technology.

公开(公告)号：US20240140912A1

公开(公告)日：2024-05-02

申请号：US18192703

申请日：2023-03-30

申请人： Florida State University Research Foundation, Incorporated.

发明人： James H. Frederich ,  Megan M. Solans

IPC分类号： C07D215/227 ,  C07C13/68 ,  C07C22/08 ,  C07C25/22 ,  C07C35/44 ,  C07C43/215 ,  C07C49/753 ,  C07C49/755 ,  C07D215/06 ,  C07D307/79

CPC分类号： C07D215/227 ,  C07C13/68 ,  C07C22/08 ,  C07C25/22 ,  C07C35/44 ,  C07C43/215 ,  C07C49/753 ,  C07C49/755 ,  C07D215/06 ,  C07D307/79 ,  C07C2603/40

摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein is versatile polyene cyclization strategy that exploits conjugated β-ionyl derivatives. Photomediated disruption of the extended π-system within these chromophores unveils a contra-thermodynamic polyene that engages in a Heck-type cyclization to afford [4.4.1]-propellanes. The connectivity of overbred polycycles generated from this process is controlled by the position of the requisite C-Halide bond. Thus, compared to conventional biomimetic polyene cyclization, this approach allows for complete control of regiochemistry and facilitates incorporation of both electron-rich and electron-deficient (hetero)aryl groups. This strategy was successfully applied to the total synthesis of abietanes such as, for example, taxodione and salviasperanol, two isomeric abietane-type diterpenes that previously could not be prepared along the same synthetic pathway.

公开(公告)号：US20230382883A1

公开(公告)日：2023-11-30

申请号：US18362073

申请日：2023-07-31

申请人： VANDA PHARMACEUTICALS INC.

发明人： Deepak Phadke ,  Natalie M. Platt ,  Ravi K. Pandrapragada

IPC分类号： C07D307/81 ,  C07D307/79

CPC分类号： C07D307/81 ,  C07D307/79

摘要： A process for preparing a batch of highly purified, pharmaceutical grade tasimelteon comprises analyzing a batch of tasimelteon synthesized under GMP conditions for the presence of one or more identified impurities.

公开(公告)号：US20230227421A1

公开(公告)日：2023-07-20

申请号：US18147189

申请日：2022-12-28

申请人： ATAI Life Sciences AG

发明人： Robert B. PERNI ,  Glenn SHORT ,  Tanweer A. KHAN

IPC分类号： C07D317/58 ,  C07D307/79 ,  C07D319/18

CPC分类号： C07D317/58 ,  C07D307/79 ,  C07D319/18

摘要： Provided herein are compounds of Formula (I), Formula (II), and Formula (III) or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7 and A are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), Formula (II), or Formula (III) and methods of using a compound of Formula (I), Formula (II), or Formula (III) , e.g., in the treatment of a mental health disease or disorder.

公开(公告)号：US11691957B2

公开(公告)日：2023-07-04

申请号：US16897189

申请日：2020-06-09

申请人： Samsung Electronics Co., Ltd.

发明人： Yongsik Jung ,  Wataru Sotoyama ,  Hosuk Kang ,  Sungjun Kim ,  Joonghyuk Kim ,  Youngmok Son ,  Won-Joon Son ,  Yeonsook Chung

IPC分类号： C07D307/79 ,  C07D407/04 ,  C07D409/04 ,  C07D407/10 ,  C07D333/54 ,  C07D409/14 ,  C07D409/10 ,  C07D405/04 ,  C07D413/10 ,  C07D471/04 ,  C07F7/08 ,  H10K85/40 ,  H10K85/60 ,  H10K50/17 ,  H10K50/12 ,  C07D405/10 ,  C07D413/04 ,  C07D419/04 ,  C07D407/14 ,  C07D333/72 ,  H01L51/00 ,  H01L51/50 ,  C07D307/87 ,  H01L51/42

CPC分类号： C07D307/79 ,  C07D307/87 ,  C07D333/54 ,  C07D333/72 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D407/14 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D419/04 ,  C07D471/04 ,  C07F7/0816 ,  H01L51/0065 ,  H01L51/0068 ,  H01L51/0069 ,  H01L51/0072 ,  H01L51/0073 ,  H01L51/0074 ,  H01L51/0094 ,  H01L51/5024 ,  H01L51/5092 ,  H01L51/4273 ,  H01L51/5056 ,  H01L51/5072

摘要： Provided are a condensed cyclic compound represented by Formula 1 and an organic light-emitting device including the same:




wherein, in Formula 1, X1, A1, L11, a11, Ar11, Ar12, b11, R11, R12, c11, and c12 are the same as defined in the specification.

公开(公告)号：US11661406B2

公开(公告)日：2023-05-30

申请号：US17266844

申请日：2019-08-09

申请人： Daewoong Pharmaceutical Co., Ltd.

发明人： Qing Ri Li ,  Hee Kyoon Yoon

IPC分类号： C07D307/79

CPC分类号： C07D307/79

摘要： A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.

公开(公告)号：US20230150964A1

公开(公告)日：2023-05-18

申请号：US18149590

申请日：2023-01-03

申请人： VANDA PHARMACEUTICALS INC.

发明人： Deepak Phadke ,  Natalie M. Platt ,  Ravi K. Pandrapragada

IPC分类号： C07D307/81 ,  C07D307/79

CPC分类号： C07D307/81 ,  C07D307/79

摘要： A process for preparing a batch of highly purified, pharmaceutical grade tasimelteon comprises analyzing a batch of tasimelteon synthesized under GMP conditions for the presence of one or more identified impurities.

公开(公告)号：US20190192516A1

公开(公告)日：2019-06-27

申请号：US16285996

申请日：2019-02-26

申请人： AUTIFONY THERAPEUTICS LIMITED

发明人： Giuseppe ALVARO ,  Paolo DAMBRUOSO ,  Simona TOMMASI ,  Anne DECOR ,  Charles LARGE ,  Agostino MARASCO

IPC分类号： A61K31/506 ,  C07D317/46 ,  C07D405/14 ,  C07D307/94 ,  A61K31/4439 ,  C07D413/14 ,  C07D413/12 ,  C07D405/12 ,  C07D307/79

CPC分类号： A61K31/506 ,  A61K31/4439 ,  C07D307/79 ,  C07D307/94 ,  C07D317/46 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14

摘要： The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.