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公开(公告)号：US11421040B2
公开(公告)日：2022-08-23
申请号：US15993874
申请日：2018-05-31
Applicant: PFIZER INC.
Inventor： Danielle Elizabeth Dettling , Yik Andy Yeung , Kristian Todd Poulsen , Veena Krishnamoorthy , Cesar Adolfo Sommer
Abstract: The present invention provides antibodies that specifically bind to FLT3 (Fms-Like Tyrosine Kinase 3). The invention further provides bispecific antibodies that bind to FLT3 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of FLT3-mediated pathologies, including cancer such as Acute Myeloid Leukemia (AML).
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Patent Agency Ranking
公开(公告)号：US12202910B2
公开(公告)日：2025-01-21
申请号：US17849467
申请日：2022-06-24
Applicant: PFIZER INC.
Inventor： Danielle Elizabeth Dettling , Yik Andy Yeung , Kristian Todd Poulsen , Veena Krishnamoorthy , Cesar Adolfo Sommer
Abstract: The present invention provides antibodies that specifically bind to FLT3 (Fms-Like Tyrosine Kinase 3). The invention further provides bispecific antibodies that bind to FLT3 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of FLT3-mediated pathologies, including cancer such as Acute Myeloid Leukemia (AML).
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公开(公告)号：US10294304B2
公开(公告)日：2019-05-21
申请号：US15085317
申请日：2016-03-30
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien Kuo , Bijan Andre Boldajipour , Javier Fernando Chaparro Riggers , Philippe Duchateau , Roman Galetto , Alexandre Juillerat , Thomas Charles Pertel , Arvind Rajpal , Barbra Johnson Sasu , Cesar Adolfo Sommer , Julien Valton , Thomas John Van Blarcom
IPC: C07K16/28 , A61K39/395 , C12N15/63 , C07K14/725 , C07K14/705 , A61K39/00 , A61K31/7076 , A61K35/17 , A61K38/00
Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).
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公开(公告)号：US11912776B2
公开(公告)日：2024-02-27
申请号：US17695769
申请日：2022-03-15
Applicant: Pfizer Inc.
Inventor： Tracy Chia-Chien Kuo , Bijan Andre Boldajipour , Javier Fernando Chaparro Riggers , Philippe Duchateau , Roman Galetto , Alexandre Juillerat , Thomas Charles Pertel , Arvind Rajpal , Barbra Johnson Sasu , Cesar Adolfo Sommer , Julien Valton , Thomas John Van Blarcom
IPC: C07K14/705 , C07K16/28 , A61K39/395 , A61K39/00 , C12N5/10 , C07K14/725 , A61K31/7076 , C12N15/63 , A61K35/17 , C12N5/0783 , A61K38/00
CPC classification number: C07K16/2878 , A61K31/7076 , A61K35/17 , A61K39/0011 , A61K39/46 , A61K39/4631 , A61K39/464417 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/2896 , C12N5/0636 , C12N5/10 , C12N15/63 , A61K38/00 , A61K2039/505 , A61K2039/5156 , C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/02 , C07K2319/03 , C07K2319/33 , C12N2510/02
Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).
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公开(公告)号：US20220340671A1
公开(公告)日：2022-10-27
申请号：US17695769
申请日：2022-03-15
Applicant: Pfizer Inc.
Inventor： Tracy Chia-Chien KUO , Bijan Andre Boldajipour , Javier Fernando Chaparro Riggers , Philippe Duchateau , Roman Galetto , Alexandre Juillerat , Thomas Charles Pertel , Arvind Rajpal , Barbra Johnson Sasu , Cesar Adolfo Sommer , Julien Valton , Thomas John Van Blarcom
IPC: C07K16/28 , C07K14/725 , C07K14/705 , A61K39/00 , A61K31/7076 , C12N15/63 , A61K35/17 , C12N5/10 , C12N5/0783
Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).
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公开(公告)号：US11312782B2
公开(公告)日：2022-04-26
申请号：US16384719
申请日：2019-04-15
Applicant: Pfizer Inc.
Inventor： Tracy Chia-Chien Kuo , Bijan Andre Boldajipour , Javier Fernando Chaparro Riggers , Philippe Duchateau , Roman Ariel Galetto , Alexandre Juillerat , Thomas Charles Pertel , Arvind Rajpal , Barbra Johnson Sasu , Cesar Adolfo Sommer , Julien Valton , Thomas John Van Blarcom
IPC: C12N5/10 , C12N15/63 , C07K16/28 , C07K14/705 , C07K19/00 , C07K14/725 , A61K39/00 , A61K31/7076 , A61K35/17 , C12N5/0783 , A61K39/395 , A61K38/00
Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).
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