公开(公告)号：US20180170928A1

公开(公告)日：2018-06-21

申请号：US15889296

申请日：2018-02-06

Applicant: Pfizer Inc.

Inventor： MARK EDWARD SCHNUTE ,  ANDREW CHRISTOPHER FLICK ,  PETER JONES ,  NEELU KAILA ,  SCOT RICHARD MENTE ,  JOHN DAVID TRZUPEK ,  MICHAEL L. VAZQUEZ ,  GORAN MATTIAS WENNERSTAL ,  LI XING ,  EDOUARD ZAMARATSKI ,  LIYING ZHANG

IPC: C07D471/04 ,  C07D401/14

CPC classification number: C07D471/04 ,  C07D401/14

Abstract: The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.