-
公开(公告)号：US20240059799A1
公开(公告)日：2024-02-22
申请号：US18314339
申请日：2023-05-09
Applicant: Pfizer Inc. , Bristol-Myers Squibb Company
Inventor： James Reasoner APGAR , Laird BLOOM , Fang JIN , Fridrik KARLSSON , Kimberly Ann MARQUETTE , Jessica Haewon MIN DEBARTOLO , Nicole Melissa PICHE-NICHOLAS , Lioudmila TCHISTIAKOVA
CPC classification number: C07K16/468 , A61P37/02 , C12N15/63 , C07K2317/14 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92
Abstract: The present invention discloses an isolated antibody that specifically binds to TL1A, comprising a heavy chain variable region (TL1A-VH) and a light chain variable region (TL1A-VL), comprising the CDR-H1, CDR-H2, and CDR-H3 sequences of a TL1A-VH sequence selected from the group consisting of SEQ ID NO: 42, SEQ ID NO: 44, SEQ ID NO: 47, SEQ ID NO: 49, SEQ ID NO: 52, SEQ ID NO: 54, SEQ ID NO: 57, SEQ ID NO: 70, SEQ ID NO: 72, SEQ ID NO: 78, SEQ ID NO: 80, SEQ ID NO: 89, SEQ ID NO: 93, SEQ ID NO: 95, SEQ ID NO: 97, SEQ ID NO: 99, SEQ ID NO: 101, SEQ ID NO: 103, SEQ ID NO: 105, SEQ ID NO: 110, SEQ ID NO: 120; and the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 18.
-
Patent Agency Ranking
公开(公告)号：US20240117030A1
公开(公告)日：2024-04-11
申请号：US18175796
申请日：2023-02-28
Applicant: Pfizer Inc.
Inventor： Rita Diane AGOSTINELLI , James Reasoner APGAR , Eric Matthew BENNETT , Laird BLOOM , Ting CHEN , Aaron Michael D'ANTONA , Arnab DE , Fang JIN , Marion Teresa KASAIAN , Matthew Allister LAMBERT , Kimberly Ann MARQUETTE , Virginie MCMANUS , Jessica Haewon MIN DEBARTOLO , Nicole Melissa PICHE-NICHOLAS , Richard Thomas SHELDON , Lioudmila TCHISTIAKOVA , Alexander Michael Shuford BARRON , Richard Lee GIESECK, III , Xiaotian ZHONG
CPC classification number: C07K16/247 , A61K45/06 , A61P35/00 , A61K2039/505
Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.
-
公开(公告)号：US20160002357A1
公开(公告)日：2016-01-07
申请号：US14751704
申请日：2015-06-26
Applicant: Pfizer Inc.
Inventor： Chad Michael MAY , Adam Reid ROOT , William A. BRADY , Lioudmila Gennadievna TCHISTIAKOVA , Lidia MOSYAK , Laird BLOOM , Paul A. MOORE , Leslie S. JOHNSON
CPC classification number: C07K16/468 , C07K16/18 , C07K16/28 , C07K16/2809 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/94
Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.
Abstract translation: 双特异性二聚体双抗体分子及其在治疗癌症中的用途。 双特异性异二聚体双抗体分子包含两个多肽链，其连接形成识别P-钙粘蛋白肿瘤细胞相关抗原和CD3T细胞抗原的两个表位结合位点。
-
公开(公告)号：US20240052047A1
公开(公告)日：2024-02-15
申请号：US18363152
申请日：2023-08-01
Applicant: Pfizer Inc.
Inventor： Yijie GAO , Nicholas Andrew MARZE , Laird BLOOM
IPC: C07K16/28
CPC classification number: C07K16/2866 , C07K16/2803 , A61K2039/505
Abstract: The present invention relates to antibodies that specifically bind to one or both of IL27RA and gp130. The present invention further relates to bispecific antibodies that specifically bind to IL27RA and gp130. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or bispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and bispecific antibodies, and their use in diagnostics and therapeutics
-
公开(公告)号：US20200308272A1
公开(公告)日：2020-10-01
申请号：US16729421
申请日：2019-12-29
Applicant: Pfizer Inc.
Inventor： Laird BLOOM , Karl Henry NOCKA , James Reasoner APGAR , Matthew Allister LAMBERT , Mark A. FARMER
IPC: C07K16/24 , A61K39/395
Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to IL-33, as well as uses, and associated methods thereof.
-
公开(公告)号：US20180037644A1
公开(公告)日：2018-02-08
申请号：US15495172
申请日：2017-04-24
Applicant: Pfizer Inc.
Inventor： Laird BLOOM , Karl Henry NOCKA , James Reasoner APGAR , Matthew Allister LAMBERT , Mark A. FARMER
IPC: C07K16/24 , A61K39/395
Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to IL-33, as well as uses, and associated methods thereof.
-
-
-
-
-
Search Results
6
records
(took 0.016 seconds)
