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公开(公告)号：US11220494B2
公开(公告)日：2022-01-11
申请号：US16942209
申请日：2020-07-29
Applicant: Pfizer Inc.
Inventor： Ping Chen , Sujin Cho-Schultz , Judith Gail Deal , Gary Michael Gallego , Mehran Jalaie , Robert Steven Kania , Sajiv Krishnan Nair , Sacha Ninkovic , Suvi Tuula Marjukka Orr , Cynthia Louise Palmer
IPC: C07D407/14 , C07D401/14 , C07D487/04 , C07D498/04
Abstract: This invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt thereof, in which R-groups R1 to R23, A, Q, U, V, W, X, Y, Z, n, p and q are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.
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公开(公告)号：US10766884B2
公开(公告)日：2020-09-08
申请号：US16391836
申请日：2019-04-23
Applicant: Pfizer Inc.
Inventor： Ping Chen , Sujin Cho-Schultz , Judith Gail Deal , Gary Michael Gallego , Mehran Jalaie , Robert Steven Kania , Sajiv Krishnan Nair , Sacha Ninkovic , Suvi Tuula Marjukka Orr , Cynthia Louise Palmer
IPC: C07D407/14 , C07D401/14 , C07D487/04 , C07D498/04
Abstract: This invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt thereof, in which R-groups R1 to R23, A, Q, U, V, W, X, Y, Z, n, p and q are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.
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公开(公告)号：US20190330196A1
公开(公告)日：2019-10-31
申请号：US16391836
申请日：2019-04-23
Applicant: Pfizer Inc.
Inventor： Ping Chen , Sujin Cho-Schultz , Judith Gail Deal , Gary Michael Gallego , Mehran Jalaie , Robert Steven Kania , Sajiv Krishnan Nair , Sacha Ninkovic , Suvi Tuula Marjukka Orr , Cynthia Louise Palmer
IPC: C07D407/14 , C07D401/14 , C07D487/04 , C07D498/04
Abstract: This invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt thereof, in which R-groups R1 to R23, A, Q, U, V, W, X, Y, Z, n, p and q are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.
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公开(公告)号：US09260439B2
公开(公告)日：2016-02-16
申请号：US14677112
申请日：2015-04-02
Applicant: PFIZER INC.
Inventor： Ping Chen , Hengmiao Cheng , Judith Gail Deal , Gary Michael Gallego , Mehran Jalaie , John Charles Kath , Suvi Tuula Marjukka Orr , Hong Shen , Luke Raymond Zehnder
IPC: A61K31/5377 , C07D487/04 , C07F9/6561 , A61K45/06 , A61N5/10
CPC classification number: C07D487/04 , A61K31/5377 , A61K45/06 , A61N5/10 , C07F9/65616
Abstract: The present invention relates to compounds of formula (X) or pharmaceutically acceptable salts thereof, wherein R1-R50, a, b, d, e, f, g, h, i, j, k, l, o, p, q, r, s, t, u, y, and z are defined herein. The novel dihydropyrrolopyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
Abstract translation: 本发明涉及式（X）化合物或其药学上可接受的盐，其中R 1 -R 50，a，b，d，e，f，g，h，i，j，k，l，o，p，q， r，s，t，u，y和z在本文中定义。 新型二氢吡咯并嘧啶衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 另外的实施方案涉及含有化合物的药物组合物和使用化合物和组合物治疗哺乳动物异常细胞生长的方法。
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公开(公告)号：US20220324872A1
公开(公告)日：2022-10-13
申请号：US17841138
申请日：2022-06-15
Applicant: Pfizer Inc.
Inventor： Douglas Carl Behenna , Ping Chen , Kevin Daniel Freeman-Cook , Robert Louis Hoffman , Mehran Jalaie , Asako Nagata , Sajiv Krishnan Nair , Sacha Ninkovic , Martha Alicia Ornelas , Cynthia Louise Palmer , Eugene Yuanjin Rui
IPC: C07D487/04 , C07D471/04 , C07D401/14
Abstract: This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
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Patent Agency Ranking
公开(公告)号：US11203594B2
公开(公告)日：2021-12-21
申请号：US16849329
申请日：2020-04-15
Applicant: Pfizer Inc.
Inventor： Samit Kumar Bhattacharya , Douglas Carl Behenna , Kimberly O. Cameron , Ping Chen , John M. Curto , Kevin Daniel Freeman-Cook , Mehran Jalaie , Robert Steven Kania , Yajing Lian , Sajiv Krishnan Nair , Cynthia Louise Palmer , Martin Youngjin Pettersson , Eugene Yuanjin Rui , Matthew Sammons , Qingyi Yang , Liying Zhang
IPC: C07D471/04 , A61P9/12
Abstract: This invention relates to compounds of general Formula I in which A, R1, R2, R3 and R4 are as defined herein, and the pharmaceutically acceptable salts thereof; to pharmaceutical compositions comprising such compounds and salts; to methods of using such compounds, salts and compositions for treating pulmonary hypertension and related diseases, like pulmonary arterial hypertension; to methods of using such compounds, salts and compositions for treating abnormal cell growth, such as cancer; and to processes to make such compounds, salts and compositions.
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公开(公告)号：US20190135817A1
公开(公告)日：2019-05-09
申请号：US16251032
申请日：2019-01-17
Applicant: Pfizer Inc.
Inventor： Douglas Carl Behenna , Ping Chen , Kevin Daniel Freeman-Cook , Robert Louis Hoffman , Mehran Jalaie , Asako Nagata , Sajiv Krishnan Nair , Sacha Ninkovic , Martha Alicia Ornelas , Cynthia Louise Palmer , Eugene Yuanjin Rui
IPC: C07D487/04 , C07D401/14 , C07D471/04
Abstract: This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R2 , R2A , R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
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公开(公告)号：US10800783B2
公开(公告)日：2020-10-13
申请号：US16251032
申请日：2019-01-17
Applicant: Pfizer Inc.
Inventor： Douglas Carl Behenna , Ping Chen , Kevin Daniel Freeman-Cook , Robert Louis Hoffman , Mehran Jalaie , Asako Nagata , Sajiv Krishnan Nair , Sacha Ninkovic , Martha Alicia Ornelas , Cynthia Louise Palmer , Eugene Yuanjin Rui
IPC: A61K31/519 , A61K31/4375 , A61K31/4545 , C07D487/04 , C07D401/12 , C07D471/04 , C07D401/14
Abstract: This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
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公开(公告)号：US10662204B2
公开(公告)日：2020-05-26
申请号：US16263185
申请日：2019-01-31
Applicant: PFIZER INC.
Inventor： Simon Planken , Hengmiao Cheng , Michael Raymond Collins , Jillian Elyse Spangler , Alexei Brooun , Andreas Maderna , Cynthia Palmer , Maria Angelica Linton , Asako Nagata , Ping Chen
IPC: C07D403/12 , C07D403/14 , C07D407/14 , C07D487/10 , A61P35/00 , C07D519/00 , C07D471/04 , C07D487/04 , C07D417/14 , C07D413/14 , A61P25/00
Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and administration of these compounds to patients to treat pancreatic, lung, colon and other cancers.
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公开(公告)号：US10590115B2
公开(公告)日：2020-03-17
申请号：US16265012
申请日：2019-02-01
Applicant: PFIZER INC.
Inventor： Simon Planken , Hengmiao Cheng , Michael Raymond Collins , Jillian Elyse Spangler , Alexei Brooun , Andreas Maderna , Cynthia Palmer , Maria Angelica Linton , Asako Nagata , Ping Chen
IPC: C07D403/14 , C07D487/10 , A61P35/00 , C07D403/04 , C07D239/94
Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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