公开(公告)号：US20210230196A1

公开(公告)日：2021-07-29

申请号：US17190924

申请日：2021-03-03

申请人： PFIZER INC.

发明人： Martin James Wythes ,  Indrawan James McAlpine ,  Ryan Patman ,  Eugene Yuanjin Rui ,  Andrew Fensome ,  Andreas Maderna ,  Mehran Jalaie ,  Ketan S. Gajiwala

IPC分类号： C07F9/6574 ,  A61K47/68 ,  A61P35/00 ,  C07H19/213

摘要： Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US10538542B2

公开(公告)日：2020-01-21

申请号：US16297910

申请日：2019-03-11

申请人： PFIZER INC.

发明人： Martin James Wythes ,  Indrawan James McAlpine ,  Ryan Patman ,  Eugene Yuanjin Rui ,  Andrew Fensome ,  Andreas Maderna ,  Mehran Jalaie ,  Ketan S. Gajiwala

IPC分类号： A61K31/7084 ,  C07H21/02 ,  C07H21/04 ,  C07F9/6574 ,  A61K47/68 ,  A61P35/00

摘要： Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US20220324872A1

公开(公告)日：2022-10-13

申请号：US17841138

申请日：2022-06-15

申请人： Pfizer Inc.

发明人： Douglas Carl Behenna ,  Ping Chen ,  Kevin Daniel Freeman-Cook ,  Robert Louis Hoffman ,  Mehran Jalaie ,  Asako Nagata ,  Sajiv Krishnan Nair ,  Sacha Ninkovic ,  Martha Alicia Ornelas ,  Cynthia Louise Palmer ,  Eugene Yuanjin Rui

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D401/14

摘要： This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

公开(公告)号：US11203594B2

公开(公告)日：2021-12-21

申请号：US16849329

申请日：2020-04-15

申请人： Pfizer Inc.

发明人： Samit Kumar Bhattacharya ,  Douglas Carl Behenna ,  Kimberly O. Cameron ,  Ping Chen ,  John M. Curto ,  Kevin Daniel Freeman-Cook ,  Mehran Jalaie ,  Robert Steven Kania ,  Yajing Lian ,  Sajiv Krishnan Nair ,  Cynthia Louise Palmer ,  Martin Youngjin Pettersson ,  Eugene Yuanjin Rui ,  Matthew Sammons ,  Qingyi Yang ,  Liying Zhang

IPC分类号： C07D471/04 ,  A61P9/12

摘要： This invention relates to compounds of general Formula I in which A, R1, R2, R3 and R4 are as defined herein, and the pharmaceutically acceptable salts thereof; to pharmaceutical compositions comprising such compounds and salts; to methods of using such compounds, salts and compositions for treating pulmonary hypertension and related diseases, like pulmonary arterial hypertension; to methods of using such compounds, salts and compositions for treating abnormal cell growth, such as cancer; and to processes to make such compounds, salts and compositions.

公开(公告)号：US11142525B2

公开(公告)日：2021-10-12

申请号：US16679820

申请日：2019-11-11

申请人： Pfizer Inc.

发明人： Rebecca Anne Gallego ,  Sajiv Krishnan Nair ,  Robert Steven Kania ,  Omar Khaled Ahmad ,  Ted William Johnson ,  Jamison Bryce Tuttle ,  Mehran Jalaie ,  Michele Ann McTigue ,  Dahui Zhou ,  Matthew L. Del Bel ,  Ru Zhou ,  Mingying He ,  Anne-Marie Dechert Schmitt

IPC分类号： C07D471/04 ,  A61P35/00

摘要： This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R1a, R2, R3, R4, and (R5)a are as defined herein, to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable salts thereof, and to methods of using such compounds, pharmaceutically acceptable salts and compositions for the treatment of abnormal cell growth, including cancer.

公开(公告)号：US20190135817A1

公开(公告)日：2019-05-09

申请号：US16251032

申请日：2019-01-17

申请人： Pfizer Inc.

发明人： Douglas Carl Behenna ,  Ping Chen ,  Kevin Daniel Freeman-Cook ,  Robert Louis Hoffman ,  Mehran Jalaie ,  Asako Nagata ,  Sajiv Krishnan Nair ,  Sacha Ninkovic ,  Martha Alicia Ornelas ,  Cynthia Louise Palmer ,  Eugene Yuanjin Rui

IPC分类号： C07D487/04 ,  C07D401/14 ,  C07D471/04

摘要： This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R2 , R2A , R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

公开(公告)号：US20240197703A1

公开(公告)日：2024-06-20

申请号：US18144737

申请日：2023-05-08

申请人： PFIZER INC.

发明人： Joyann Barber ,  Sujin Cho-Schultz ,  Matthew L. Del Bel ,  Rebecca Anne Gallego ,  Mingying He ,  Mehran Jalaie ,  Robert Steven Kania ,  Michele Ann McTigue ,  Sajiv Krishnan Nair ,  Anne-Marie Dechert Schmitt ,  Jamison Bryce Tuttle ,  Dahui Zhou ,  Ru Zhou

IPC分类号： A61K31/444 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00

CPC分类号： A61K31/444 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00

摘要： This invention relates to compounds of general Formula I






and pharmaceutically acceptable salts thereof, in which R1, R2, R3a, R3b, and R4 are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

公开(公告)号：US11964978B2

公开(公告)日：2024-04-23

申请号：US17693197

申请日：2022-03-11

申请人： PFIZER INC.

发明人： Ketan Satish Gajiwala ,  Chan Woo Huh ,  Mehran Jalaie ,  Ryan Lloyd Patman ,  Eugene Yuanjin Rui ,  Jianmin Sun ,  Martin James Wythes

IPC分类号： C07D487/04 ,  A61K31/437 ,  A61K31/519 ,  A61P35/00 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D471/04

摘要： Provided herein are compounds of the general formula (I):




and pharmaceutically acceptable salts thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US10968242B2

公开(公告)日：2021-04-06

申请号：US16702738

申请日：2019-12-04

申请人： PFIZER INC.

发明人： Martin James Wythes ,  Indrawan James McAlpine ,  Ryan Patman ,  Eugene Yuanjin Rui ,  Andreas Maderna ,  Mehran Jalaie ,  Ketan S. Gajiwala

IPC分类号： A61K31/7084 ,  A61K47/68 ,  A61P35/00 ,  C07H21/02 ,  C07H21/04 ,  C07F9/6574 ,  C07H19/213

摘要： Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US10800783B2

公开(公告)日：2020-10-13

申请号：US16251032

申请日：2019-01-17

申请人： Pfizer Inc.

发明人： Douglas Carl Behenna ,  Ping Chen ,  Kevin Daniel Freeman-Cook ,  Robert Louis Hoffman ,  Mehran Jalaie ,  Asako Nagata ,  Sajiv Krishnan Nair ,  Sacha Ninkovic ,  Martha Alicia Ornelas ,  Cynthia Louise Palmer ,  Eugene Yuanjin Rui

IPC分类号： A61K31/519 ,  A61K31/4375 ,  A61K31/4545 ,  C07D487/04 ,  C07D401/12 ,  C07D471/04 ,  C07D401/14

摘要： This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.