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1.发明申请Aroyl-O-Piperidine Derivatives for the Treatment of Diabetes-Related Problems 有权用于治疗糖尿病相关问题的芳酰基-O-哌啶衍生物公开(公告)号：US20070254919A1
公开(公告)日：2007-11-01
申请号：US11629176
申请日：2005-05-19
申请人： Philippe Guedat , Francois Collonges , Olivier Chevreuil , Herve Dumas , Marie Denault , Stephane Yvon , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt
发明人： Philippe Guedat , Francois Collonges , Olivier Chevreuil , Herve Dumas , Marie Denault , Stephane Yvon , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt
IPC分类号： A61K31/445 , A61P3/10 , C07D211/06
CPC分类号： C07D211/46 , C07D211/96 , C07D213/12 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12
摘要： The present invention relates to derivatives of aroyl-O-piperidine structure of the general formula (I): in which R1, R2, R3 and R4 are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper-triglyceridaemia, hypercholesterolaemia and dyslipidaemia, and to the prevention or treatment of obesity.
摘要翻译： 本发明涉及通式（I）的芳酰基-O-哌啶结构的衍生物：其中R 1，R 2，R 3， SUP>和R 4'如说明书中所定义。 式（I）化合物用于治疗高甘油三酯血症，高胆固醇血症和血脂异常，以及预防或治疗肥胖症的应用。
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2.发明授权Aroyl-O-piperidine derivatives for the treatment of diabetes-related problems 有权芳酰基-O-哌啶衍生物用于治疗糖尿病相关问题公开(公告)号：US07723358B2
公开(公告)日：2010-05-25
申请号：US11629176
申请日：2005-05-19
申请人： Philippe Guedat , Francois Collonges , Olivier Chevreuil , Hervé Dumas , Marie Noelle Denault , Stéphane Yvon , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt
发明人： Philippe Guedat , Francois Collonges , Olivier Chevreuil , Hervé Dumas , Marie Noelle Denault , Stéphane Yvon , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D211/46 , C07D211/96 , C07D213/12 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12
摘要： The present invention relates to derivatives of aroyl-O-piperidine structure of the general formula (I): in which R1, R2, R3 and R4 are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper-triglyceridaemia, hypercholesterolaemia and dyslipidaemia, and to the prevention or treatment of obesity.
摘要翻译： 本发明涉及通式（I）的芳酰基-O-哌啶结构的衍生物：其中R1，R2，R3和R4如说明书中所定义。 式（I）化合物用于治疗高甘油三酯血症，高胆固醇血症和血脂异常，以及预防或治疗肥胖症的应用。
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3.发明申请THIAZOLYLIMIDAZOLE DERIVATIVES AN THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN 审中-公开它们作为微量TRIGLYCERIDE转移蛋白的抑制剂使用的三唑基咪唑衍生物公开(公告)号：US20100137601A1
公开(公告)日：2010-06-03
申请号：US12700441
申请日：2010-02-04
IPC分类号： C07D401/14
CPC分类号： C07D417/14
摘要： The present invention relates to thiazolylimidazole derivatives of the general formula (I) in which: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3; and R1, R2, R3, R4, R5, R6, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
摘要翻译： 本发明涉及通式（I）的噻唑咪唑衍生物，其中：G表示选自基团g1，g2和g3的键或二价基团; 并且R1，R2，R3，R4，R5，R6，Y和Z如说明书中所定义。 式（I）化合物用于治疗高甘油三酯血症，高胆固醇血症和血脂异常。
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4.发明申请Thiazolylimidazole Derivatives and Their Use as Inhibitors of Microsmal Triglyceride Transfer Protein 失效噻唑咪唑衍生物及其作为微量甘油三酯转运蛋白的抑制剂公开(公告)号：US20080214610A1
公开(公告)日：2008-09-04
申请号：US10587975
申请日：2005-01-17
IPC分类号： A61K31/4545 , C07D417/14 , A61P3/06 , A61K31/454
CPC分类号： C07D417/14
摘要： The present invention relates to thiazolylimidazole derivatives of the general formula (I) in which: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3; and R1, R2, R3, R4, R5, R6, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
摘要翻译： 本发明涉及通式（I）的噻唑咪唑衍生物，其中：G表示选自基团g1，g2和g3的键或二价基团; 和R 1，R 2，R 3，R 4，R 5， R 6，Y和Z如说明书中所定义。 式（I）化合物用于治疗高甘油三酯血症，高胆固醇血症和血脂异常。
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5.发明授权Thiazolylimidazole derivatives and their use as inhibitors of microsomal triglyceride transfer protein 失效噻唑咪唑衍生物及其作为微粒体甘油三酯转移蛋白的抑制剂公开(公告)号：US07767819B2
公开(公告)日：2010-08-03
申请号：US10587975
申请日：2005-01-17
IPC分类号： C07D417/04 , A61K31/4535
CPC分类号： C07D417/14
摘要： The present invention relates to thiazolylimidazole derivatives of the general formula (I) in which: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3; and R1, R2, R3, R4, R5, R6, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
摘要翻译： 本发明涉及通式（I）的噻唑咪唑衍生物，其中：G表示选自基团g1，g2和g3的键或二价基团; 并且R1，R2，R3，R4，R5，R6，Y和Z如说明书中所定义。 式（I）化合物用于治疗高甘油三酯血症，高胆固醇血症和血脂异常。
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公开(公告)号：US20090036481A1
公开(公告)日：2009-02-05
申请号：US11658596
申请日：2005-06-28
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to 7-azaindole-based compounds, to processes for the preparation thereof, to pharmaceutical compositions comprising them, and to the use thereof in the preparation of medicaments that are useful as inhibitors of MTP and of ApoB secretion.
摘要翻译： 本发明涉及7-氮杂吲哚类化合物，其制备方法，包含它们的药物组合物，以及其用于制备可用作MTP抑制剂和ApoB分泌的药物的用途。
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公开(公告)号：US07838533B2
公开(公告)日：2010-11-23
申请号：US11658596
申请日：2005-06-28
IPC分类号： C07D471/02 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention relates to 7-azaindole-based compounds, to processes for the preparation thereof, to pharmaceutical compositions comprising them, and to the use thereof in the preparation of medicaments that are useful as inhibitors of MTP and of ApoB secretion.
摘要翻译： 本发明涉及7-氮杂吲哚类化合物，其制备方法，包含它们的药物组合物，以及其用于制备可用作MTP抑制剂和ApoB分泌的药物的用途。
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