公开(公告)号：US20240245613A1

公开(公告)日：2024-07-25

申请号：US18433057

申请日：2024-02-05

Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Ayala LAMPEL ,  Avigail-Elah BARUCH LESHEM ,  Amit BEN-AMAR

IPC: A61K9/50 ,  A61K47/42 ,  C07K7/06 ,  C07K7/08

CPC classification number: A61K9/5052 ,  A61K47/42 ,  C07K7/06 ,  C07K7/08

Abstract: The invention provides a peptide liquid droplet a composition the same and methods for the delivery of an active ingredient, as disclosed herein. The composition comprises a peptide liquid droplet and an active agent encapsulated in the peptide liquid droplet. Further provided are a method for encapsulation of an active agent in a peptide liquid droplet; method for manufacturing an active ingredient in the peptide liquid droplet and a method for the delive

公开(公告)号：US20240002895A1

公开(公告)日：2024-01-04

申请号：US18209263

申请日：2023-06-13

Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Avigail-Elah BARUCH LESHEM ,  Ayala LAMPEL ,  Tlalit MASSARANO

IPC: C12P21/02

CPC classification number: C12P21/02

Abstract: The invention relates to a composition comprising a polymer-based droplet, wherein the polymer-based droplet comprises one or more of melanin, a tyrosine substrate with a cleavable protecting group on the side chain, tyrosine, tyrosinase and any combination thereof. The composition further relates to a method of synthesizing melanin comprising the steps of: obtaining a polymer-based droplet containing a tyrosine substrate with a cleavable protecting group on the side chain (protected tyrosine) or a polymer-based droplet containing tyrosine (unprotected); wherein the tyrosine is oxidized by tyrosinase and polymerizes so as to obtain melanin.