公开(公告)号：US20190060477A1

公开(公告)日：2019-02-28

申请号：US16079123

申请日：2017-02-24

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Ronit SATCHI-FAINARO ,  Evgeni PISAREVSKY ,  Anat ELDAR-BOOCK ,  Dikla BEN-SHUSHAN ,  Yana EPSHTEIN ,  Anna SCOMPARIN

IPC: A61K47/65 ,  A61K47/59 ,  A61K31/4184 ,  A61K31/506 ,  A61P35/04

Abstract: Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.

公开(公告)号：US20230277677A1

公开(公告)日：2023-09-07

申请号：US18140681

申请日：2023-04-28

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Evgeni PISAREVSKY ,  Anat ELDAR-BOOCK ,  Dikla BEN-SHUSHAN ,  Yana EPSHTEIN ,  Anna SCOMPARIN

IPC: A61K47/65 ,  A61K9/51 ,  A61K47/64 ,  A61P35/00 ,  A61K47/59 ,  A61P35/04 ,  A61K31/4184 ,  A61K31/506

CPC classification number: A61K47/65 ,  A61K9/5153 ,  A61K47/645 ,  A61P35/00 ,  A61K47/59 ,  A61P35/04 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/4745

Abstract: Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.