公开(公告)号：US20170014531A1

公开(公告)日：2017-01-19

申请号：US15124360

申请日：2015-03-13

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Ronit SATCHI-FAINARO ,  Doron SHABAT ,  Rachel BLAU ,  Yana EPSHTEIN ,  Hemda BAABUR-COHEN ,  Shiran FERBER ,  Orit REDY-KEISAR ,  Einat KISIN-FINFER

IPC: A61K49/00 ,  A61K31/337 ,  A61K47/48

CPC classification number: A61K49/0054 ,  A61K31/337 ,  A61K47/58 ,  A61K47/593 ,  A61K47/65 ,  A61K49/0032

Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.

Abstract translation: 公开了可用于有机应用的聚合体系。 聚合体系包含荧光或荧光部分和治疗活性剂，各自连接到相同或不同的聚合物部分。 聚合物体系被设计成使得响应于化学事件产生荧光信号，优选在接触在患病组织或器官中过度表达的分析物（例如酶）时产生荧光信号。 还公开了可用于包含在这种聚合物体系中的探针，制备这种探针的方法和聚合物体系，以及其在诊断和/或治疗应用中的用途。

公开(公告)号：US20230277677A1

公开(公告)日：2023-09-07

申请号：US18140681

申请日：2023-04-28

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Evgeni PISAREVSKY ,  Anat ELDAR-BOOCK ,  Dikla BEN-SHUSHAN ,  Yana EPSHTEIN ,  Anna SCOMPARIN

IPC: A61K47/65 ,  A61K9/51 ,  A61K47/64 ,  A61P35/00 ,  A61K47/59 ,  A61P35/04 ,  A61K31/4184 ,  A61K31/506

CPC classification number: A61K47/65 ,  A61K9/5153 ,  A61K47/645 ,  A61P35/00 ,  A61K47/59 ,  A61P35/04 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/4745

Abstract: Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.

公开(公告)号：US20200078475A1

公开(公告)日：2020-03-12

申请号：US16687789

申请日：2019-11-19

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Doron SHABAT ,  Rachel BLAU ,  Yana EPSHTEIN ,  Hemda BAABUR-COHEN ,  Shiran FERBER ,  Orit REDY-KEISAR ,  Einat KISIN-FINFER

IPC: A61K49/00 ,  A61K31/337 ,  A61K47/65 ,  A61K47/59 ,  A61K47/58

Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.

公开(公告)号：US20190060477A1

公开(公告)日：2019-02-28

申请号：US16079123

申请日：2017-02-24

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Ronit SATCHI-FAINARO ,  Evgeni PISAREVSKY ,  Anat ELDAR-BOOCK ,  Dikla BEN-SHUSHAN ,  Yana EPSHTEIN ,  Anna SCOMPARIN

IPC: A61K47/65 ,  A61K47/59 ,  A61K31/4184 ,  A61K31/506 ,  A61P35/04

Abstract: Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.