公开(公告)号：US20210244828A1

公开(公告)日：2021-08-12

申请号：US17054938

申请日：2019-05-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Eran PERLSON ,  Roy MAIMON ,  Oded BEHAR

IPC: A61K48/00 ,  C12N15/113 ,  A61K9/00 ,  A61P25/28

Abstract: The present invention relates to methods for treating motor neuron diseases and neuromuscular junction abnormalities. Particularly, the methods comprise increasing miRNA126-5p expression in skeletal muscle cells and/or motor neurons, and/or inhibiting miRNA126-5p expression in glial cells, thereby spatially up-regulating and/or down-regulating miRNA126-5p levels, and thus treating amyotrophic lateral sclerosis.

公开(公告)号：US20180267014A1

公开(公告)日：2018-09-20

申请号：US15925999

申请日：2018-03-20

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Eran PERLSON ,  Izhak MICHAELEVSKI ,  Ariel IONESCU ,  Anton SHEININ

IPC: G01N33/487 ,  B01L3/00 ,  C12M1/42 ,  C12M1/34 ,  C12M3/06 ,  C12M1/00

CPC classification number: G01N33/48728 ,  B01L3/502715 ,  C12M1/22 ,  C12M1/3407 ,  C12M1/42 ,  C12M23/16 ,  C12M23/20

Abstract: A microfluidic chamber, including: an internal compartment sized and shaped for culturing cells; an external compartment surrounding at least part of the internal compartment, sized and shaped for culturing cells; at least one flow path connecting the internal compartment and the external compartment, sized and shaped to allow penetration of cell extensions from the internal compartment into the external compartment, wherein the internal compartment, the external compartment and the at least one flow path are formed on a base layer of the microfluidic chamber; at least one micro-pattern in the base layer of said microfluidic chamber shaped and sized to align cells cultured in the microfluidic chamber relative to each other.