公开(公告)号：US20180318428A1

公开(公告)日：2018-11-08

申请号：US15764429

申请日：2016-09-30

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Ronit SATCHI-FAINARO ,  Anna SCOMPARIN ,  Dina POLYAK ,  Adva KRIVITSKY ,  Shay ELIYAHU ,  Hadas GIBORI

IPC: A61K47/59 ,  A61K31/7105 ,  A61K31/711 ,  C12N15/113

CPC classification number: C08G69/48 ,  A61K31/7088 ,  A61K38/00 ,  C08G69/10 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/31 ,  C12N2320/32 ,  C12Y207/11001

Abstract: Polymers useful for associating therewith oligonucleotides and for delivering the oligonucleotides into a cell, conjugates comprising these polymers and an oligonucleotide associated therewith, and compositions comprising same are provided. Also provided are uses of these conjugates in, for example, gene therapy, and particularly gene silencing. The disclosed polymers feature a PGA backbone, and amine-terminated pendant groups attached to at least 40% of the backbone units, and optionally further comprise alkyl pendant groups and/or other nitrogen-containing pendant groups attached to other one or more portions of the backbone units. The disclosed polymers can be cross-linked or can form a part of a block-copolymer.