公开(公告)号：US3546261A

公开(公告)日：1970-12-08

申请号：US3546261D

申请日：1969-11-26

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  LILAS LES ,  PATURET MICHEL

IPC: C07J5/00 ,  C07J75/00 ,  C07C169/32

CPC classification number: C07J5/00 ,  C07J75/00 ,  Y10S514/861

公开(公告)号：US3510544A

公开(公告)日：1970-05-05

申请号：US3510544D

申请日：1967-06-27

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  PATURET MICHEL

IPC: C07F9/12 ,  C07F9/08 ,  A61K27/00

CPC classification number: C07F9/12

公开(公告)号：US3576921A

公开(公告)日：1971-04-27

申请号：US3576921D

申请日：1968-02-13

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  PATURET MICHEL

IPC: C07F9/09 ,  A61K21/00 ,  C07F9/08

CPC classification number: A61K31/70 ,  C07F9/091

Abstract: X-(1,4-PHENYLENE)-CH(-OH)-CH(-NH-CO-CH(-CL)2)-

CH2-O-R(=O)-(OH)2

WHEREIN X IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF NITRO, ACETYL AND METHYLSULFONYL, AND ITS THERAPEUTICALLY-COMPATIBLE SALTS, PROCESS OF PREPARATION OF THE PHOSPHATE ESTER AND METHODS OF THERAPY UTILIZING THE PHOSPHATE ESTER. THE SAID PHOSPHATE ESTERS HAVE AN IMPORTANT ANTIBIOTIC AND BACTERICIDAL ACTION COUPLED WITH EXCELLENT SOLUBILITY IN WATER.
A PHOSPHATE ESTER SELECTED FROM THE GROUP CONSISTING OF THE 0-3-MONOPHSOPHASE OF D-THREO-1-PARA-X-PHENYL-2-DI CHLOROACETAMIDO-PROPANE-1,3-DIOL OF THE FORMULA