公开(公告)号：US3910922A

公开(公告)日：1975-10-07

申请号：US83014869

申请日：1969-06-03

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  MEIER JEAN

IPC: A61K31/47 ,  C07D215/18 ,  C07D215/22 ,  C07D215/233 ,  C07D215/44 ,  C07D215/56 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  F24F3/04 ,  C07D215/14

CPC classification number: A61K31/47 ,  C07D215/18 ,  C07D215/233 ,  C07D215/44 ,  C07D215/56 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

Abstract: 7- OR 8-TRIFLUOROMETHYL-QUINOLINES OF THE FORMULA

WHEREIN N IS 1 OR 2 AND R is selected from the group consisting of saturated and unsaturated heterocyclic having an oxygen atom, a nitrogen atom or both a nitrogen and oxygen atom and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic and anti-inflammatory activity and their preparation.

Abstract translation: 7-或8-三氟甲基喹啉，其中N为1或2，R选自具有氧原子，氮原子或氮原子和氧原子的饱和和不饱和杂环及其无毒性 ，具有镇痛和抗炎活性的药学上可接受的酸加成盐及其制备。

公开(公告)号：US3632818A

公开(公告)日：1972-01-04

申请号：US3632818D

申请日：1969-01-02

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  GIRAULT PIERRE

IPC: A01N43/56 ,  C07D231/52 ,  C07D49/06

CPC classification number: C07C243/00 ,  C07D231/52

Abstract: 3-AMINO-4,4-DIHALO-5-PYRAZOLONES OF THE FORMULA

1-Y,3-(R-N(-R1)-),4-X,4-X'',5-(O=)-2-PYRAZOLINE

WHEREIN X AND X'' ARE SELECTED FRO THE GROUP CONSISTING OF CHLORINE AND BROMINE, Y IS SELECTED FROM THE GROUP CONSISTING OF ALKYL, CYCLOALKYL, AND ARYL WHICH MAY BE SUBSTITUTED AND R AND R1 ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKYL, ARYL, CYCLOALKYL AND ARALKYL WHICH POSSES; FUNGICIDAL ACTIVITY AND THEIR PREPARATION.

公开(公告)号：US3546261A

公开(公告)日：1970-12-08

申请号：US3546261D

申请日：1969-11-26

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  LILAS LES ,  PATURET MICHEL

IPC: C07J5/00 ,  C07J75/00 ,  C07C169/32

CPC classification number: C07J5/00 ,  C07J75/00 ,  Y10S514/861

公开(公告)号：US3502682A

公开(公告)日：1970-03-24

申请号：US3502682D

申请日：1969-05-15

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  GIRAULT PIERRE ,  JOLY ROBERT ,  WARNANT JULIEN ,  GOFFINET BERNARD

IPC: A61K31/00 ,  A61K31/395 ,  C07D215/44 ,  C07D33/52

CPC classification number: A61K31/00 ,  A61K31/395 ,  C07D215/44

公开(公告)号：US3910898A

公开(公告)日：1975-10-07

申请号：US45760474

申请日：1974-04-03

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  MEIER JEAN

IPC: A61K31/47 ,  C07D215/44 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  F24F3/04 ,  C07D295/04

CPC classification number: A61K31/47 ,  C07D215/44 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

Abstract: 7- OR 8-TRIFLUOROMETHYL-QUINOLINES OF THE FORMULA

WHEREIN N IS 1 OR 2 AND R is morpholino and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic and anti-inflammatory activity and their preparation.

Abstract translation: 7-或8-三氟甲基喹啉，其中N为1或2，R为吗啉代及其无毒，药学上可接受的具有镇痛和抗炎活性的酸加成盐及其制备方法。

公开(公告)号：US3591612A

公开(公告)日：1971-07-06

申请号：US3591612D

申请日：1969-04-15

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE

IPC: A61K31/57 ,  A61K31/573 ,  C07J5/00 ,  F16B39/06 ,  C07C169/32

CPC classification number: A61K31/573 ,  A61K31/57 ,  C07J5/00 ,  F16B39/06 ,  Y10S514/825

Abstract: MIXED CARBONATES OF 9A-FLUORO-16A-METHYL-17A-R-$1,4PREGNADIENE-11B-21-DIOL-3,20-DIONE OF THE FORMULA

9-F,11-HO,16-CH3,17-R,22(CH3-CH2-O-(CH2-CH2-O)N-CH2-CH2-

OOC-O-)-1,4-PREGNADIENE-3,20-DIONE

WHEREIN N IS AN INTEGER FROM 0 TO 10 AND R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND HYDROXYL HAVING ANTI-INFLAMMATORY ACTIVITY AND THEIR PREPARATION.

公开(公告)号：US3502680A

公开(公告)日：1970-03-24

申请号：US3502680D

申请日：1967-03-10

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  GIRAULT PIERRE

IPC: A61K31/00 ,  C07D215/44 ,  C07D33/52

CPC classification number: A61K31/00 ,  C07D215/44

公开(公告)号：US3479360A

公开(公告)日：1969-11-18

申请号：US3479360D

申请日：1968-02-19

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE

IPC: C07D215/44 ,  C07D33/52 ,  A61K27/00

CPC classification number: C07D215/44

公开(公告)号：US3449347A

公开(公告)日：1969-06-10

申请号：US3449347D

申请日：1967-03-20

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  GIRAULT PIERRE

IPC: C07D405/12 ,  C07D33/36 ,  C07D33/48 ,  C07D33/52

CPC classification number: C07D405/12

公开(公告)号：US3644368A

公开(公告)日：1972-02-22

申请号：US78639868

申请日：1968-12-23

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  MEIER JEAN

IPC: C07D215/18 ,  C07D215/22 ,  C07D215/233 ,  C07D215/44 ,  C07D33/52

CPC classification number: C07D215/233 ,  C07D215/18 ,  C07D215/44

Abstract: NOVLE 4 - (ORTHOR-(2'',3''-DIHYDROXYPROPYLOXYCARBONYL)PHENYL)-AMINO-QUINOLINES OF THE FORMULA

4-((2-(R''-O-CH2-CH(-O-R)-CH2-OOC-)PHENYL)-NH-),CF3-

QUINOLINE

WHEREIN THE CF3 RADICAL IS IN THE 7 OR 8-POSITION, R AND R'' ARE HYDROGEN AND TAKEN TOGETHER FORM A KETONIDE OF THE FORMULA

-C(-P)(-Q)-

P AND O BEING SELECTED FROM THE GROUP COSISTING OF ALKYL ARALKYL AND ARYL AND THE NON-TOXIC, PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS WHEN R AND R'' ARE HYDROGEN'', WHICH POSSESS NOTABLE ANTI-INFLAMMATORY ACTIVITY AND INTENSE ANALGESIC ACTIVITY.

Abstract translation: 下式的新型4- [邻 - （2'，3'-二羟基丙氧基羰基） - 苯基] - 氨基 - 喹啉CF 3基团在七或八位，R和R'是氢并且一起形成酮 当R和R'是氢时，式P和Q选自烷基芳烷基和芳基以及无毒的药学上可接受的加成盐，其具有显着的抗炎活性和强烈的镇痛活性。