Process for production of demonomethylated colchicinic derivatives
    7.
    发明授权
    Process for production of demonomethylated colchicinic derivatives 失效
    去甲基化秋水仙碱衍生物的生产工艺

    公开(公告)号:US3410899A

    公开(公告)日:1968-11-12

    申请号:US40688364

    申请日:1964-10-27

    Applicant: ROUSSEL UCLAF

    CPC classification number: A01N45/02 G04B13/021

    Abstract: Novel compounds of Formula I in which R is hydrogen or a C1- 18 acyl group, R1 is a C1- 18 acyl group, and R2 is a alkoxy or C1- 6 alkylthio group, are prepared by subjecting a compound of Formula I in which R is a methyl group to the action of chloride of a tetravalent metal as catalyst, whereby the 1-methoxy group is dimethylated, and, if required, the resulting product is simultaneously or subsequently reacted with a lower acylating agent.

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