公开(公告)号：US06420473B1

公开(公告)日：2002-07-16

申请号：US09501866

申请日：2000-02-10

申请人： Ramireddy Chittamuru ,  George Reyes ,  Thomas P. Farrell ,  Charles F. Vesey ,  Dev K. Mehra ,  Hans-Ulrich Petereit ,  Klaus Lehmann

发明人： Ramireddy Chittamuru ,  George Reyes ,  Thomas P. Farrell ,  Charles F. Vesey ,  Dev K. Mehra ,  Hans-Ulrich Petereit ,  Klaus Lehmann

IPC分类号： C08J312

CPC分类号： A61K9/2893 ,  A61K9/2813 ,  A61K9/2846 ,  A61K47/02

摘要： A non-toxic, edible, enteric film coating, dry powder composition for use in making an aqueous enteric suspension which may be used in coating pharmaceutical tablets comprises a) an acrylic resin, said resin comprising i) from 20 to 85 percent by weight of at least one alkyl acrylate or alkyl methacrylate moiety, ii) from 80 to 15 percent by weight of at least one vinyl or vinylidene moiety having a carboxylic acid group capable of salt formation, and iii) from 0 to 30 percent by weight of at least one other vinyl or vinylidene moiety copolymerizable with i) and ii), b) an alkalizing agent capable of reacting with the acrylic resin such that, after reaction, 0.1 to 10 mole percent of the acidic groups in 1a-ii) are present in the salt form, and c) a detackifier.

摘要翻译： 可用于制备可用于包衣药物片剂的水性肠溶悬浮液的无毒，可食用的肠溶薄膜包衣干粉组合物包括a）丙烯酸树脂，所述树脂包含i）20至85重量％ 至少一种丙烯酸烷基酯或甲基丙烯酸烷基酯部分，ii）80至15重量％的至少一个具有能够形成盐的羧酸基团的乙烯基或亚乙烯基部分，和iii）至少0至30重量％ 可与i）和ii）共聚的另一个乙烯基或亚乙烯基部分，b）能够与丙烯酸类树脂反应的碱化剂，使得反应后，1a-ii）中的0.1〜10摩尔％的酸性基团存在于 盐形式，和c）防粘剂。