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公开(公告)号：US20130172846A1
公开(公告)日：2013-07-04
申请号：US13814009
申请日：2011-08-04
申请人： Ravi V. Bellamkonda , Anjana Jain
发明人： Ravi V. Bellamkonda , Anjana Jain
IPC分类号： A61M5/00
CPC分类号： A61M5/00 , A61K9/0092 , A61K9/70 , A61K31/05 , A61K31/4355 , A61K31/443 , A61K31/704 , A61K47/34 , A61K47/593 , A61K47/6435 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2400/12 , C08L89/00 , C08L75/04 , C08L67/04
摘要： Methods, devices, and systems are provided for guiding tumor movement, particularly in vivo for treatment of patients. The method may include implanting into a tissue site where tumor cells are present a device having one or more surface structures or substrates, such as aligned nanofibers, which provide physical guidance cues for directing the migration of the tumor cells from the first tissue location to a selected second location, for tumor cell extraction or death. The devices and systems may include a cytotoxic agent for contacting tumor cells migrated via the substrate. All or a portion of the at least one substrate may include one or more biochemical cues, such as a coating of laminin or another protein, which may be provided in a concentration gradient to facilitate uni-directional tumor cell migration.
摘要翻译： 提供方法，装置和系统用于引导肿瘤移动，特别是用于治疗患者的体内。 该方法可以包括植入组织部位，其中肿瘤细胞存在具有一个或多个表面结构或底物的装置，例如排列的纳米纤维，其提供用于引导肿瘤细胞从第一组织位置迁移到 选择第二个位置，用于肿瘤细胞提取或死亡。 所述装置和系统可包括用于接触通过底物迁移的肿瘤细胞的细胞毒性剂。 至少一个底物的全部或一部分可以包括一种或多种生物化学提示，例如层粘连蛋白或另一种蛋白质的包衣，其可以浓度梯度提供以促进单向肿瘤细胞迁移。
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公开(公告)号：US11273250B2
公开(公告)日：2022-03-15
申请号：US13814009
申请日：2011-08-04
IPC分类号： A61M5/00 , A61K9/70 , A61K9/00 , A61K31/4355 , A61K31/443 , A61K47/34 , A61K31/704 , A61K31/05 , A61L31/16 , A61L31/06 , A61L31/10 , A61K47/64 , A61K47/59
摘要： Methods, devices, and systems are provided for guiding tumor movement, particularly in vivo for treatment of patients. The method may include implanting into a tissue site where tumor cells are present a device having one or more surface structures or substrates, such as aligned nanofibers, which provide physical guidance cues for directing the migration of the tumor cells from the first tissue location to a selected second location, for tumor cell extraction or death. The devices and systems may include a cytotoxic agent for contacting tumor cells migrated via the substrate. All or a portion of the at least one substrate may include one or more biochemical cues, such as a coating of laminin or another protein, which may be provided in a concentration gradient to facilitate uni-directional tumor cell migration.
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公开(公告)号：US20180120254A1
公开(公告)日：2018-05-03
申请号：US15657809
申请日：2017-07-24
申请人： Anjana Jain
发明人： Anjana Jain
IPC分类号： G01N27/414 , H01L29/12 , H01L29/10 , H01L29/49 , G01N33/543 , G01N33/574 , C12Q1/6886 , C12Q1/6825
CPC分类号： G01N27/4146 , C12Q1/6825 , C12Q1/6883 , C12Q1/6886 , C12Q2600/178 , G01N27/4145 , G01N33/5438 , G01N33/57484 , G01N33/588 , G01N2800/28 , G01N2800/2821 , H01L29/1025 , H01L29/127 , H01L29/495
摘要： An array of biosensors diagnosing biomarkers device and a drug delivery vehicle system including a plurality of biosensor arrays for diagnosing biomarkers concentrations, and a delivery vehicle dispensing drug, a electronic interface, a plurality of algorithms to relate biomarker concentrations and drug dispensed, wherein biosensors in said plurality of biosensor arrays are constructed from quantum dot field-effect transistors, and wherein one or more layers of cladded quantum dots are assembled in the channel, gate, and channel and gate regions of FETs, and wherein quantum dots are functionalized by DNA aptamers, antisense oligoneuclotides (ASOs), and DNAs, to sense biomarkers concentrations comprising at least one of proteins, miRNAs, and genes, and wherein the concentrations of biomarkers changes and their values change the magnitude of drain current as a function of time, and wherein the drain current signal is processed by an electronic interface.
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