公开(公告)号：US4331819A

公开(公告)日：1982-05-25

申请号：US143372

申请日：1980-04-24

Applicant: Robert McCall

Inventor： Robert McCall

IPC: C07C201/16 ,  B01J14/00 ,  B01J19/14 ,  C07C67/00 ,  C07C201/00 ,  C07C201/02 ,  C07C201/08 ,  C07C205/06 ,  C07C205/10 ,  C07C205/11 ,  C07C205/12 ,  C07C209/36 ,  C07C76/02 ,  C07C79/10

CPC classification number: B01J14/00 ,  B01J19/14 ,  C07C201/08 ,  C07C209/36 ,  Y02P20/142

Abstract: The invention relates to a process for the preparation of nitrated aromatic compounds by the mixed acid process, in which water is removed from the reaction mass by passing an inert gas through it.

Abstract translation: 本发明涉及通过混合酸法制备硝化芳族化合物的方法，其中通过使惰性气体通过反应物料将水从反应物料中除去。

公开(公告)号：US3981935A

公开(公告)日：1976-09-21

申请号：US639875

申请日：1975-12-10

Applicant: Robert McCall

Inventor： Robert McCall

IPC: C07C205/06 ,  C07C79/10

CPC classification number: C07C201/08

Abstract: A duplex process for the mononitration of benzene wherein the nitration is carried out in an azeotropic first stage followed by a lower temperature, mixed-acid second stage. The azeotropic stage uses reaction temperatures of at least 120.degree.C in mixed HNO.sub.3 --H.sub.2 SO.sub.4, and excess water is carried overhead as an azeotrope with part of the benzene and is then decanted from the benzene. The nitrated benzene is removed as bottoms and decanted from the acid phase, avoiding the necessity of reconcentrating the H.sub.2 SO.sub.4. Both the nitrated benzene bottoms and the organic, benzene-containing part of the overhead stream are supplied to the second stage for completing the conversion into mononitrobenzene in mixed acid at lower temperatures such as 70.degree.C.

Abstract translation: 用于苯的单硝化的双相方法，其中硝化在共沸的第一阶段中进行，随后是较低温度的混合酸的第二阶段。 共沸阶段在混合的HNO3-H2SO4中使用至少120℃的反应温度，过量的水作为与一部分苯的共沸物塔顶馏出，然后从苯中倾出。 硝化的苯作为底部物质被去除并从酸相中倾析出来，避免了再浓缩H 2 SO 4的必要性。 将硝化苯底物和塔顶馏出物的有机，含苯部分都供入第二阶段，以完成在较低温度如70℃下在混合酸中转化成单硝基苯。

公开(公告)号：US20060040929A1

公开(公告)日：2006-02-23

申请号：US11191247

申请日：2005-07-27

Applicant: Robert McCall ,  Martin Meglasson ,  Brad Acker ,  Richard Heier ,  Alan Jin ,  Malcolm Moon

Inventor： Robert McCall ,  Martin Meglasson ,  Brad Acker ,  Richard Heier ,  Alan Jin ,  Malcolm Moon

IPC: A61K31/5415 ,  A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/06 ,  A61K31/4745 ,  A61K31/5415

Abstract: The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) in a dosage range where the sexually therapeutic amount is from about 0.2 thru 8 mg/person/dose and where the sexually mating amount is from about 0.003 thru 0.2 mg/kg/dose. The present invention also provides a novel pharmaceutical agent, (5R)-5 -(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione and pharmaceutically acceptable salts thereof.

Abstract translation: 本发明是一种治疗人类性骚扰并在非人哺乳动物中使用式（A）化合物在性治疗量为约0.2至8mg /人/剂量的剂量范围内诱导交配的方法，其中 性交配量为约0.003至0.2mg / kg /剂量。 本发明还提供了一种新型药剂，（5R）-5-（甲基氨基）-5,6-二氢-4H-咪唑并[4,5,1-ij]喹啉-2（1H） - 硫酮及其药学上可接受的盐 其中。