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公开(公告)号:US20080053901A1
公开(公告)日:2008-03-06
申请号:US11847983
申请日:2007-08-30
申请人: Robert Mierendorf , Herbert Paaren , Anthony Grabski , Andrew Wilke , Joerg Baier , Anil Oroskar
发明人: Robert Mierendorf , Herbert Paaren , Anthony Grabski , Andrew Wilke , Joerg Baier , Anil Oroskar
CPC分类号: F16K11/022 , B01D15/1842 , B01D15/3804 , Y10T137/86533 , Y10T137/86654
摘要: The present invention provides devices and methods for micro-scale simulated moving bed chromatography (SMB) for continuous preparation of analytic quantities of highly pure fractions of target molecules. The present apparatus and method of the invention is adapted in a preferred embodiment to separations by affinity chromatography involving three discontinuous liquid flow loops. An alternative embodiment of affinity chromatography utilizes standard SMB operating under isocratic conditions.
摘要翻译: 本发明提供用于连续制备分析量高的目标分子的高纯度级分的微尺度模拟移动床层析(SMB)的装置和方法。 本发明的本发明的装置和方法在优选实施方案中适用于通过亲和层析分离,涉及三个不连续的液体流动循环。 亲和层析的另一个实施方案利用在等度条件下操作的标准SMB。