Valve setup for SMB chromatography

    公开(公告)号:US11879561B2

    公开(公告)日:2024-01-23

    申请号:US17749928

    申请日:2022-05-20

    发明人: Dinesh Shukla

    IPC分类号: B01D15/18 F16K27/12 F16K27/02

    摘要: A valve setup for SMB chromatography includes a cassette block, a control block, a swiveling door, and a flexible pressurizing tube. The cassette block is configured to control each of a plurality of valves when an operation surface is in close contact with a control surface of the cassette block. The swiveling door is hinged to the valve control block such that an open state of the door arranges the cassette block such that the control surface is at the operation surface of the control block, and a closed position holds the cassette block with an inner surface of the swiveling door abutting a rear surface of the cassette block opposite the control surface. The flexible pressurizing tube is arranged at the inner surface of the swiveling door so the pressurizing tube presses against the rear surface of the cassette block when the pressure in the tube is increased.

    VALVE SETUP FOR SMB CHROMATOGRAPHY
    2.
    发明公开

    公开(公告)号:US20230356108A1

    公开(公告)日:2023-11-09

    申请号:US17738359

    申请日:2022-05-06

    发明人: Dinesh Shukla

    IPC分类号: B01D15/18 F16K31/06 F16K7/12

    摘要: An assembly is provided that comprises:



    at least one valve cassette block (20) comprising a plurality of valves (25) which are controllable via a control surface (24) of the valve cassette block (20);
    a valve control block (10) having an operation surface (11), the valve control block (10) being configured to control each of the plurality of valves (25) when the operation surface (11) is in contact with the control surface (24) of the at least one valve cassette block (20), the valve control block (10) comprising at least one sliding trench (14) formed in the operation surface (11);
    at least one sliding component (30) configured to slidably interlock with the at least one sliding trench (14) such that the at least one sliding component (30) is movable relative to the valve control block (10) in a sliding direction parallel to the operation surface (11),
    at least one pulling bracket (40, 50) configured to embrace the at least one valve cassette block (20) and to interact with the at least one sliding component (30) such that a sliding movement of the at least one sliding component (30) in the at least one sliding trench (14) causes the pulling bracket (40, 50) to pull the at least one valve cassette block (20) with its control surface (24) against the operation surface (11) of the valve control block (10).

    Stackable Planar Adsorptive Devices
    7.
    发明申请
    Stackable Planar Adsorptive Devices 有权
    可堆叠平面吸附装置

    公开(公告)号:US20140339170A1

    公开(公告)日:2014-11-20

    申请号:US13964726

    申请日:2013-08-12

    IPC分类号: B01D15/20

    摘要: Adsorptive bed devices include a scaffold in housing having a stress absorbing rigid structure and open cells filled with adsorptive beads. The scaffold restricts movement of the plurality of adsorptive beads, absorbs compressive stress induced by a hydraulic pressure gradient along a direction of liquid flow and transfers a portion of the induced compressive stress to the housing. In one embodiment the adsorptive bed in packed into a chromatography column, and in another embodiment the adsorptive bed is sealed in a monolithic block.

    摘要翻译: 吸附床装置包括具有应力吸收刚性结构的壳体中的支架和填充有吸附珠的开放细胞。 支架限制多个吸附珠的运动,吸收沿着液体流动方向由液压梯度引起的压缩应力,并将一部分感应的压缩应力传递到壳体。 在一个实施方案中,将填充到色谱柱中的吸附床,在另一个实施方案中,将吸附床密封在整体块中。

    Simulated moving bed separation device
    8.
    发明授权
    Simulated moving bed separation device 有权
    模拟移动床分离装置

    公开(公告)号:US08722955B2

    公开(公告)日:2014-05-13

    申请号:US12988077

    申请日:2009-03-24

    IPC分类号: B01D15/18 C07C7/12

    CPC分类号: B01D15/1842

    摘要: A device (SMB) for separation by simulated moving bed adsorption comprises a plurality of elementary adsorption zones Zi in series operating in a closed loop, and at least one singular adsorption zone with a dead volume which is greater than the adsorption zones Zi, the solid adsorbant of said singular adsorption zone having a granulometry which is lower than that of the solid adsorbant of the ordinary adsorption zones.

    摘要翻译: 用于通过模拟移动床吸附分离的装置(SMB)包括串联操作在闭环中的多个基本吸附区Zi和至少一个具有大于吸附区Z i的死体积的单一吸附区,固体 所述奇异吸附区的吸附剂具有比常规吸附区的固体吸附剂低的粒度测定法。

    VALVE BLOCK ASSEMBLY
    9.
    发明申请
    VALVE BLOCK ASSEMBLY 有权
    阀块组件

    公开(公告)号:US20120241034A1

    公开(公告)日:2012-09-27

    申请号:US13488842

    申请日:2012-06-05

    IPC分类号: G05D7/03

    摘要: A device to enhance sealing is provided. The device includes a body and a pressure cup. The pressure cup includes a channel, a first pressure channel, and a second pressure channel. The channel is formed in a surface of the body to surround a first portion of the surface. The channel is configured to hold an o-ring. The first pressure channel extends through the body and opens into the first portion of the surface. The second pressure channel extends through the body and opens into the channel. Pneumatic pressure within the second pressure channel is controlled to hold the o-ring in the channel when a second pressure within the first pressure channel changes.

    摘要翻译: 提供了一种增强密封性的装置。 该装置包括主体和压力杯。 压力杯包括通道,第一压力通道和第二压力通道。 通道形成在主体的表面中以包围表面的第一部分。 通道配置为保持O形环。 第一压力通道延伸穿过主体并且通向表面的第一部分。 第二压力通道延伸穿过主体并且通向通道。 当第一压力通道内的第二压力改变时,第二压力通道内的气压被控制以将O形环保持在通道中。

    DEVICE FOR DISTRIBUTING FLUIDS IN A SIMULATED MOVING BED COLUMN WITH A LIMITED DEGREE OF IMMERSION WITHIN THE GRANULAR BED
    10.
    发明申请
    DEVICE FOR DISTRIBUTING FLUIDS IN A SIMULATED MOVING BED COLUMN WITH A LIMITED DEGREE OF IMMERSION WITHIN THE GRANULAR BED 有权
    在模拟的移动板柱中分配流体的装置,其中有一个在颗粒床中的浸没有限度

    公开(公告)号:US20110303602A1

    公开(公告)日:2011-12-15

    申请号:US13154874

    申请日:2011-06-07

    IPC分类号: B01D24/00

    摘要: The present invention describes a device for the distribution of fluids in a multi-stage column operating in simulated moving bed (SMB) mode comprising, in the direction of flow of the principal fluid, a distribution system (6) for auxiliary fluids, and a distributor plate (10) supported by stiffening elements (7) located below said plate (10), said device being interposed between two successive beds of granular solid (2) denoted the upstream and downstream bed, the distribution system and the stiffening elements being immersed in the upstream and downstream granular beds to a slight extent with an upper limit for the degree of immersion.

    摘要翻译: 本发明描述了一种用于在以模拟移动床(SMB)模式操作的多级塔中分配流体的装置,其包括在主流体的流动方向上用于辅助流体的分配系统(6) 分配器板(10)由位于所述板(10)下方的加强元件(7)支撑,所述装置插入在表示为上游和下游床的两个连续的颗粒状固体床(2)之间,分配系统和加强元件被浸没 在上游和下游颗粒床中的微小程度具有浸渍程度的上限。