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    Nucleic acid analysis methods conducted in small reaction volumes
    1.
    发明申请
    Nucleic acid analysis methods conducted in small reaction volumes 审中-公开
    在小反应体积中进行核酸分析方法

    公开(公告)号：US20050106596A1

    公开(公告)日：2005-05-19

    申请号：US10928965

    申请日：2004-08-27

    申请人： Zbigniev Skrzypczynski ,  Joerg Baier ,  Karl Nichols

    发明人： Zbigniev Skrzypczynski ,  Joerg Baier ,  Karl Nichols

    IPC分类号： C07H21/04 ,  C12M1/34 ,  C12N20060101 ,  C12P19/34 ,  C12Q1/68 ,  C12Q1/70

    CPC分类号： C12Q1/6827

    摘要： The present invention relates to reactions conducted on or in solid surface materials, including liquid phase reactions within capillary tubes and arrays of capillary tubes or open end reaction microchambers. A wide array of biomolecular and combinatorial synthesis reactions may be used with the present invention. For example, the present invention provides methods for forming and cleaving nucleic acid cleavage structures on or in solid surface materials.

    摘要翻译： 本发明涉及在固体表面材料上或固体表面材料中进行的反应，包括毛细管内的液相反应和毛细管阵列或开放端反应微室。 本发明可以使用各种各样的生物分子和组合合成反应。 例如，本发明提供了在固体表面材料上或固体表面材料中形成和切割核酸裂解结构的方法。

    Reagent transfer device
    3.
    发明授权
    Reagent transfer device 失效
    试剂转移装置

    公开(公告)号：US5882930A

    公开(公告)日：1999-03-16

    申请号：US966893

    申请日：1997-11-10

    申请人： Joerg Baier

    发明人： Joerg Baier

    IPC分类号： B01J19/00 ,  C40B60/14 ,  G01N35/00 ,  G01N35/10

    CPC分类号： G01N35/1074 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00369 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01L2300/0893 ,  C40B60/14 ,  G01N2035/00237 ,  G01N2035/1037 ,  G01N35/1065 ,  Y10T436/11 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

    摘要： The present device is directed to a reagent transfer device for transferring a plurality of reagent samples from one location to another location having a deposit surface. The device includes a reagent tray having a top surface with a top surface area and a plurality of wells in the ratio of at least 1,000 wells per square centimeter of top surface area, and a transfer member having a transfer surface with a plurality of pins extending therefrom. Each of the pins is positioned to correspond to one of the wells so that when the transfer member is moved in the Z-direction the pins are simultaneously dipped into the corresponding wells. The device further includes a mechanism for moving the transfer member between a first position in which reagent from the wells is deposited onto the corresponding pins and a second position in which reagent on the pins is deposited on the deposit surface. The mechanism for moving is adapted to move the transfer member in the X-direction, the Y-direction and the Z-direction.

    摘要翻译： 本装置被引导到用于将多个试剂样品从一个位置转移到具有沉积表面的另一位置的试剂转移装置。 该装置包括具有顶表面区域的顶表面和多于每平方厘米顶表面积至少1,000个孔的比例的多个孔的试剂托盘和具有多个销延伸的转移表面的转移构件 由此。 每个销定位成对应于其中一个井，使得当传送构件沿Z方向移动时，销同时浸入相应的井中。 该装置还包括用于在第一位置和第二位置之间移动转移构件的机构，其中来自孔的试剂沉积到相应的引脚上，其中在引脚上的试剂沉积在沉积表面上的第二位置。 移动机构适于在X方向，Y方向和Z方向上移动传送构件。

    Reagent transfer device
    9.
    发明授权
    Reagent transfer device 失效
    试剂转移装置

    公开(公告)号：US06255119B1

    公开(公告)日：2001-07-03

    申请号：US09161155

    申请日：1998-09-25

    申请人： Joerg Baier

    发明人： Joerg Baier

    IPC分类号： B01L302

    CPC分类号： G01N35/1074 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00369 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01L2300/0893 ,  C40B60/14 ,  G01N35/1065 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/11 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

    摘要： The present device is directed to a reagent transfer device for transferring a plurality of reagent samples from one location to another. A transfer plate has a top surface with reservoirs, a bottom surface with orifices, and channels connecting the reservoirs and orifices. Fluid is moved from the reservoirs, through the channels and out of the orifices to form samples on the bottom surface about the orifices. A movement apparatus is provided for bringing the samples into contact with deposit surfaces at various deposition positions. Arrays of at least 100 orifices per square centimeter are provided.

    摘要翻译： 本装置被引导到用于将多个试剂样品从一个位置转移到另一个位置的试剂转移装置。 转印板具有带有储存器的顶表面，具有孔的底表面和连接储存器和孔的通道。 流体从储存器通过通道移出孔口，以在孔的底部表面上形成样品。 提供移动装置，用于使样品与各种沉积位置的沉积物接触。 提供每平方厘米至少100个孔的阵列。