公开(公告)号：US20180231570A1

公开(公告)日：2018-08-16

申请号：US15943104

申请日：2018-04-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andrea Horsch ,  Birgit Klapperich ,  Dirk Block ,  Alfred Engel ,  Johann Karl ,  Rosemarie Kientsch-Engel ,  Ekaterina Manuilova ,  Christina Rabe ,  Sandra Rutz ,  Monika Soukupova ,  Ursula-Henrike Wienhues-Thelen ,  Peter Kastner ,  Edelgard Anna Kaiser

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/68 ,  G01N33/74 ,  G01N2333/47 ,  G01N2333/8139 ,  G01N2800/347 ,  G01N2800/50

Abstract: The present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) during or after a surgical procedure or after administration of a contrast medium. The method is based on the determination of the level of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) in a body fluid sample obtained from the patient prior to the surgical procedure or prior to the administration of a contrast medium. Further, the present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) based on the determination of the amount of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) and Cystatin C in a body fluid sample obtained from the patient. The present disclosure further encompasses kits and devices adapted to carry out the methods of the disclosed methods.