公开(公告)号：US20190292535A1

公开(公告)日：2019-09-26

申请号：US16074128

申请日：2012-11-08

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： David Casagolda Vallribera ,  Frank Kroner ,  Michael Schraeml

IPC: C12N15/10 ,  C40B40/06 ,  C12N15/62

Abstract: The present disclosure is directed to a library of chimeric polypeptides comprising one or more fragments from the peptidyl-prolyl cis/trans isomerase or FKBP family displaying one or more polypeptides on one or more FKBP members and its use in methods for the screening and selection of constrained peptide surrogates exhibiting binding activity versus predetermined target molecules.

公开(公告)号：US10414818B2

公开(公告)日：2019-09-17

申请号：US15025230

申请日：2014-09-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Schraeml ,  David Casagolda Vallribera ,  Frank Kroner

IPC: C07K16/12 ,  G01N33/577

Abstract: The present description relates to anti-Thermus thermophilus SlyD FKBP domain antibodies and methods of using the same.

公开(公告)号：US20160237144A1

公开(公告)日：2016-08-18

申请号：US15025230

申请日：2014-09-22

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Michael Schraeml ,  David Casagolda Vallribera ,  Frank Kroner

IPC: C07K16/12 ,  G01N33/577

CPC classification number: C07K16/1203 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92 ,  G01N33/577

Abstract: The present description relates to anti-Thermus thermophilus SlyD FKBP domain antibodies and methods of using the same.

Abstract translation: 本说明书涉及抗栖热菌嗜热链球菌SlyD FKBP结构域抗体及其使用方法。