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公开(公告)号:US20180256696A1
公开(公告)日:2018-09-13
申请号:US15761012
申请日:2016-09-23
发明人: Julia Vipond , Kevin Bewley
IPC分类号: A61K39/02 , C07K14/195 , C07K16/12 , G01N33/569 , A61K45/06
CPC分类号: A61K39/0208 , A61K45/06 , A61K2039/575 , C07K14/195 , C07K14/29 , C07K16/1203 , G01N33/56911
摘要: The present invention provides antigens, for use in the treatment or prevention of C. burnetii infection. Also provided are nucleic acids encoding such antigens, and antibodies raised against such antigens.
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公开(公告)号:US20180252709A1
公开(公告)日:2018-09-06
申请号:US15969493
申请日:2018-05-02
发明人: Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
IPC分类号: G01N33/543 , C07K16/12 , C12Q1/24 , G01N1/34 , G01N33/569 , C12N13/00
CPC分类号: G01N33/54333 , C07K16/1203 , C07K16/1267 , C07K2317/33 , C12N13/00 , C12Q1/24 , G01N1/34 , G01N33/569
摘要: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.
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公开(公告)号:US09988454B2
公开(公告)日:2018-06-05
申请号:US15159829
申请日:2016-05-20
申请人: Immunwork Inc.
发明人: Tse-Wen Chang , Hsing-Mao Chu , Chien-Jen Lin , Chun-Yu Lin
IPC分类号: A61K47/48 , A61K31/137 , C07K16/10 , C07K16/12 , C07K16/18 , C07K16/28 , C07K17/06 , C07K14/565 , C07K7/08 , C07K14/00 , C07K17/02 , A61K47/65 , A61K47/60 , A61K47/64 , A61K47/68
CPC分类号: C07K16/283 , A61K31/137 , A61K47/60 , A61K47/64 , A61K47/65 , A61K47/6849 , A61K47/6883 , C07K7/08 , C07K14/001 , C07K14/565 , C07K16/1027 , C07K16/1203 , C07K16/18 , C07K16/2839 , C07K16/2881 , C07K17/02 , C07K17/06 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2319/33 , C07K2319/70 , C07K2319/74
摘要: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
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公开(公告)号:US20180105587A1
公开(公告)日:2018-04-19
申请号:US15851272
申请日:2017-12-21
申请人: APO-T B.V.
CPC分类号: C07K16/18 , C07K16/082 , C07K16/087 , C07K16/10 , C07K16/1018 , C07K16/1045 , C07K16/1081 , C07K16/1203 , C07K16/1214 , C07K16/1217 , C07K16/1242 , C07K16/1271 , C07K16/1275 , C07K16/1292 , C07K16/2833 , C07K2317/21 , C07K2317/31 , C07K2317/32 , C07K2317/55
摘要: A first aspect of the disclosure relates to the field of binding molecules targeted at pathogens. The disclosure further relates to proteinaceous binding molecules targeting cells displaying pathogen-associated molecular patterns, in particular targeting cell surface molecules associated with or derived from pathogens, more in particular cell surface proteins displaying peptides from intracellular (pathogen associated) proteins.
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公开(公告)号:US09938340B2
公开(公告)日:2018-04-10
申请号:US14877475
申请日:2015-10-07
发明人: Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
IPC分类号: C07K16/22 , C12N9/90 , C07K16/12 , G01N33/74 , C07K16/40 , G01N33/573 , C07K14/475 , C07K14/65
CPC分类号: C07K16/22 , C07K14/475 , C07K14/65 , C07K16/1203 , C07K16/40 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/24 , C07K2319/35 , C07K2319/41 , C07K2319/43 , C12N9/90 , C12Y502/01008 , G01N33/573 , G01N33/74 , G01N2333/99
摘要: Herein is reported a fusion polypeptide according to formula I NH2—S2—X1—S1—COOH (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.
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公开(公告)号:US09913904B2
公开(公告)日:2018-03-13
申请号:US15433497
申请日:2017-02-15
申请人: MAT-MALTA ADVANCED TECHNOLOGIES LIMITED , FREISTAAT BAYERN REPRESENTED BY JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG
CPC分类号: A61K39/40 , A61K2039/507 , C07K16/1203 , C07K16/1232 , C07K16/1235 , C07K16/1275 , C07K16/1282 , C07K16/14 , C07K2317/11 , C07K2317/23
摘要: The present invention relates to the use of a composition selected from the group consisting of antibodies, antibody fragments, insulin-like growth factor antagonists, Toll-like receptor antagonists and mixtures thereof for the treatment or the prophylaxis of certain diseases.
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公开(公告)号:US09815886B2
公开(公告)日:2017-11-14
申请号:US14592727
申请日:2015-01-08
申请人: ADMA Biologics, Inc.
IPC分类号: A61K39/42 , C07K16/06 , A61K39/395 , C07K16/08 , C07K16/10 , A61K45/06 , G01N33/68 , C07K16/12 , A61K39/155 , A61K39/00
CPC分类号: C07K16/06 , A61K39/155 , A61K39/39516 , A61K39/42 , A61K45/06 , A61K2039/507 , C07K16/08 , C07K16/10 , C07K16/1009 , C07K16/1027 , C07K16/1203 , C07K16/1232 , C07K16/1242 , C07K16/1271 , C07K16/1275 , C07K16/1282 , C07K16/1285 , C07K16/1289 , C07K2317/10 , C07K2317/21 , C07K2317/31 , C07K2317/76 , G01N33/6854 , Y02A50/466 , Y02A50/469
摘要: The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).
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公开(公告)号:US20170269080A1
公开(公告)日:2017-09-21
申请号:US15474427
申请日:2017-03-30
发明人: Jason A. Carlyon
IPC分类号: G01N33/569 , A61K39/02 , C07K16/12
CPC分类号: G01N33/56911 , A61K39/0233 , A61K39/40 , A61K2039/552 , A61K2039/55566 , A61K2039/6031 , A61K2039/6081 , A61K2039/70 , C07K16/1203 , C07K16/1246 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2319/23 , G01N33/56983 , G01N2333/195 , G01N2333/29 , G01N2469/10 , G01N2469/20 , G01N2800/42 , Y02A50/403
摘要: Anaplasma Marginale surface protein OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. OmpA proteins or peptide fragments may be used in combination with other Anaplasmatacaea surface proteins to elicit an immune response. Furthermore, antibodies to OmpA proteins can be used in diagnostic methods to determine whether an individual has contracted an Anaplasmatacaea infection.
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公开(公告)号:US20170101482A1
公开(公告)日:2017-04-13
申请号:US15383188
申请日:2016-12-19
申请人: Kymab Limited
发明人: Allan BRADLEY , E-Chiang LEE , Qi LIANG , Wei WANG , Glenn FRIEDRICH
IPC分类号: C07K16/46 , A01K67/027
CPC分类号: A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号:US20170094956A1
公开(公告)日:2017-04-06
申请号:US15383353
申请日:2016-12-19
申请人: Kymab Limited
发明人: Allan BRADLEY , E-Chiang LEE , Qi LIANG , Wei WANG , Anais LEGENT , Ian KIRBY
IPC分类号: A01K67/027 , C07K16/12 , C07K16/18
CPC分类号: A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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