公开(公告)号：US20220065825A1

公开(公告)日：2022-03-03

申请号：US17444330

申请日：2021-08-03

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Indranil Mitra

IPC: G01N30/20 ,  G01N30/32 ,  G01N30/22

Abstract: A liquid chromatography (LC) system comprises an LC switching valve comprising a sample input port, aspiration pump port, needle seat port, waste port leading to a waste, LC pump port and an LC column port. A sample aspiration needle is fluidically connected to the sample input port via a sample receiving conduit, an aspiration pump is fluidically connected to the aspiration pump port. The LC system includes a needle seat fluidically connected to the needle seat port via a needle seat conduit, an LC column fluidically connected to the LC column port, and an LC pump fluidically connected to the LC pump port, for injecting the sample into the LC column when the sample aspiration needle is seated into the needle seat and when the LC pump port is fluidically connected to the needle seat port and the sample input port is fluidically connected to the LC column port.

公开(公告)号：US20240385155A1

公开(公告)日：2024-11-21

申请号：US18694492

申请日：2022-09-22

Applicant: Roche Diagnostics Operations, Inc. ,  Hitachi High-Tech Corporation

Inventor： Robert Lang ,  Indranil Mitra ,  Yuichiro Hashimoto ,  Yuka Sugawara

IPC: G01N30/86 ,  G01N30/02 ,  G01N30/32 ,  G01N30/72

Abstract: An analytical system comprising a mass spectrometer and an ionization source. The analytical system further comprises an analytical fluidic system connectable to the ionization source for infusing samples into the mass spectrometer via the ionization source, a downstream pump fluidically connectable to the ionization source via the downstream valve, where the downstream pump is fluidically connected to a plurality of fluid containers comprising respective fluids, the fluids comprising a concentrated composition for calibrating the mass spectrometer and at least one diluent for diluting the at least one concentrated composition. The analytical system further comprises a controller configured to control the downstream pump to obtain at least one diluted composition by automatically mixing a concentrated composition with a diluent with a predetermined dilution factor, to infuse the diluted composition into the ionization source, to obtain a mass spectrum of the diluted composition and to execute a calibration of the mass spectrometer. A respective automated analytical method.

公开(公告)号：US11898997B2

公开(公告)日：2024-02-13

申请号：US17444330

申请日：2021-08-03

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Indranil Mitra

IPC: G01N30/20 ,  G01N30/22 ,  G01N30/32 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/22 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/326

Abstract: A liquid chromatography (LC) system comprises an LC switching valve comprising a sample input port, aspiration pump port, needle seat port, waste port leading to a waste, LC pump port and an LC column port. A sample aspiration needle is fluidically connected to the sample input port via a sample receiving conduit, an aspiration pump is fluidically connected to the aspiration pump port. The LC system includes a needle seat fluidically connected to the needle seat port via a needle seat conduit, an LC column fluidically connected to the LC column port, and an LC pump fluidically connected to the LC pump port, for injecting the sample into the LC column when the sample aspiration needle is seated into the needle seat and when the LC pump port is fluidically connected to the needle seat port and the sample input port is fluidically connected to the LC column port.

公开(公告)号：US20230333069A1

公开(公告)日：2023-10-19

申请号：US18337020

申请日：2023-06-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thomas Hoffmann ,  Peter Kupser ,  Andreas Leinenbach ,  Indranil Mitra ,  Jatin Nandania ,  Cornelia Werner

IPC: G01N30/12 ,  G01N30/72

CPC classification number: G01N30/12 ,  G01N30/7233 ,  G01N2030/027

Abstract: The present invention relates to a method for detecting and/or quantifying an analyte in a sample using mass spectrometry. The method of the invention comprises: extracting the analyte from the sample using solid phase extraction (SPE) so as to obtain an SPE extract comprising the analyte, concentrating the analyte, said concentrating comprising evaporating solvent from the SPE-extract; and detecting and/or quantifying the analyte in the sample using mass spectrometry.