公开(公告)号：US11287402B2

公开(公告)日：2022-03-29

申请号：US17113164

申请日：2020-12-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stefan Quint ,  Marian Roetzer ,  Florian Schweinberger ,  Benjamin Tiemann ,  Marius Wagner ,  Ralf Zimmermann

IPC: G01N30/72 ,  H01J49/04 ,  H01J49/00

Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.

公开(公告)号：US20240273436A1

公开(公告)日：2024-08-15

申请号：US18568254

申请日：2022-06-08

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thomas Heinemeyer ,  Dieter Kempken ,  Marian Roetzer ,  Lorenz Scheinpflug ,  Florian Schweinberger

IPC: G06Q10/0633 ,  G04F1/00

CPC classification number: G06Q10/0633 ,  G04F1/005

Abstract: A time tracking device (112) for monitoring system performance of at least one laboratory instrument is proposed. The time tracking device (112) comprises at least one support structure (114). The time tracking device (112) further comprises at least one electronics unit (116) and at least one motion sensor (118) housed by the support structure (114). The motion sensor (118) is configured for detecting a change of motion and/or orientation of the time tracking device (112). The electronics unit (116) is configured for measuring time, wherein a time measurement is initiated by detecting a change of motion and/or orientation of the time tracking device (112) and is terminated by detecting a subsequent change of motion and/or orientation of the time tracking device (112). The support structure (114) is a polygonal support structure (114) comprising a plurality of faces (120), wherein the support structure (114) comprises at least two interactive faces (136). Each of the interactive faces (136) comprises at least one user interface (138) comprising at least one display device (140). Each of the interactive faces (136) is configured for displaying at least one status indication (171) of the laboratory instrument, wherein the interactive face (136) matching a current status of the laboratory instrument is selectable by a user via changing motion and/or orientation of the time tracking device (112). The time tracking device (112) is con-figured for providing data relating to the measured time via at least one communication interface (172).

公开(公告)号：US20210181166A1

公开(公告)日：2021-06-17

申请号：US17113164

申请日：2020-12-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stefan Quint ,  Marian Roetzer ,  Florian Schweinberger ,  Benjamin Tiemann ,  Marius Wagner ,  Ralf Zimmermann

IPC: G01N30/72 ,  H01J49/04

Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.