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1.ANTICANCER STEROIDAL LACTONES UNSATURATED IN POSITION 7 (8) 有权
标题翻译: 不稳定位置的ANTICANCER STEROIDAL LACTONES 7(8)公开(公告)号:US20130040921A1
公开(公告)日:2013-02-14
申请号:US13642910
申请日:2011-04-26
申请人: Rogelio Fernández Rodríguez , José Fernando Reyes Benítez , Andrés Francesch Solloso , María del Carmen Cuevas Marchante
发明人: Rogelio Fernández Rodríguez , José Fernando Reyes Benítez , Andrés Francesch Solloso , María del Carmen Cuevas Marchante
IPC分类号: A61K31/585 , C07J71/00 , A61P35/00 , C07J17/00
CPC分类号: C07J19/00 , C07J71/001
摘要: A compound of general formula (I), wherein R1-R17 and the ------ line take various meanings for use in the treatment of cancer.
摘要翻译: 通式(I)的化合物,其中R1-R17和 - 线具有用于治疗癌症的各种含义。
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公开(公告)号:US08962602B2
公开(公告)日:2015-02-24
申请号:US13642910
申请日:2011-04-26
申请人: Rogelio Fernández Rodríguez , José Fernando Reyes Benítez , Andrés Francesch Solloso , María del Carmen Cuevas Marchante
发明人: Rogelio Fernández Rodríguez , José Fernando Reyes Benítez , Andrés Francesch Solloso , María del Carmen Cuevas Marchante
IPC分类号: A61K31/585 , C07J19/00 , C07J71/00
CPC分类号: C07J19/00 , C07J71/001
摘要: A compound of general formula (I), wherein R1-R17 and the - - - - - - line take various meanings for use in the treatment of cancer.
摘要翻译: 通式(I)的化合物,其中R1-R17和 - - - - 线具有用于治疗癌症的各种含义。
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公开(公告)号:US20120190870A1
公开(公告)日:2012-07-26
申请号:US13171567
申请日:2011-06-29
申请人: Ma Jesús Martín López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García- Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , María del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
发明人: Ma Jesús Martín López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García- Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , María del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
IPC分类号: C07D309/32 , C07F7/18 , C07C43/225
CPC分类号: C07D309/32
摘要: Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译: 提供了从茯苓,蔷薇科,落叶松属,物种listoistoides及其衍生物获得的抗肿瘤化合物。
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公开(公告)号:US20110118343A1
公开(公告)日:2011-05-19
申请号:US13001898
申请日:2009-07-02
申请人: José Fernando Reyes Benítez , Gloria Crespo Sueiro , Rogelio Fernández Rodríguez , Andrés Francesch Solloso , María del Carmen Cuevas Marchante
发明人: José Fernando Reyes Benítez , Gloria Crespo Sueiro , Rogelio Fernández Rodríguez , Andrés Francesch Solloso , María del Carmen Cuevas Marchante
IPC分类号: A61K31/366 , C07D498/18 , A61P35/00
CPC分类号: C07D498/18 , C07D498/22
摘要: Antitumoral compounds of general formula I: wherein R1-R14 and the lines take permitted meanings for use in the treatment of cancer.
摘要翻译: 通式I的抗肿瘤化合物:其中R1-R14和该条用于治疗癌症所允许的含义。
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公开(公告)号:US08324406B2
公开(公告)日:2012-12-04
申请号:US12304123
申请日:2007-06-15
申请人: Ma Jesús Martín López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , María del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
发明人: Ma Jesús Martín López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , María del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
IPC分类号: C07D309/30
CPC分类号: C07D309/32
摘要: Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译: 提供了从茯苓,蔷薇科,落叶松属,物种listoistoides及其衍生物获得的抗肿瘤化合物。
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公开(公告)号:US20110105409A1
公开(公告)日:2011-05-05
申请号:US13002154
申请日:2009-07-16
申请人: Raquel Rodríguez Acebes , Rogelio Fernández Rodríguez , José Fernando Reyes Benítez , Ma Jesús Martín López , Isabel Marco Martínez , Isabel Digón Juárez , Maria del Carmen Cuevas Marchante , Andrés Francesch Solloso
发明人: Raquel Rodríguez Acebes , Rogelio Fernández Rodríguez , José Fernando Reyes Benítez , Ma Jesús Martín López , Isabel Marco Martínez , Isabel Digón Juárez , Maria del Carmen Cuevas Marchante , Andrés Francesch Solloso
CPC分类号: C07K7/06
摘要: Anticancer compounds of general formula I: wherein R1-R11 take permitted meanings for use in the treatment of cancer.
摘要翻译: 通式I的抗癌化合物:其中R1-R11具有用于治疗癌症的允许含义。
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公开(公告)号:US08501968B2
公开(公告)日:2013-08-06
申请号:US13171567
申请日:2011-06-29
申请人: Ma Jesús Martin López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
发明人: Ma Jesús Martin López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
IPC分类号: C07D309/30 , A01N43/16
CPC分类号: C07D309/32
摘要: Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译: 提供了从茯苓,蔷薇科,落叶松属,物种listoistoides及其衍生物获得的抗肿瘤化合物。
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公开(公告)号:US20100048596A2
公开(公告)日:2010-02-25
申请号:US12093563
申请日:2006-11-13
申请人: Jose Fernando Reyes Benitez , Andrés Francesch Solloso , Carmen Cuevas Marchante , Marta Altuna Urquijo , Daniel Pla Queral , Mercedes Alvarez Domingo , Fernando Albericio Palomera
发明人: Jose Fernando Reyes Benitez , Andrés Francesch Solloso , Carmen Cuevas Marchante , Marta Altuna Urquijo , Daniel Pla Queral , Mercedes Alvarez Domingo , Fernando Albericio Palomera
IPC分类号: A61K31/506 , C07D403/04
CPC分类号: C07D403/04
摘要: Antitumoural compounds of general formula (I); wherein Ar is an heterocyclic group of formula (a) and R1, R2, R3, R4, R5, R6, R7, n and the dotted line take permitted meanings can be obtained from a tunicate of the family Polyclinidae, genus Aplidium, species cyaneum, and the invention further provides derivatives thereof.
摘要翻译: 通式(I)的抗肿瘤化合物; 其中Ar是式(a)的杂环基,R 1,R 2,R 3,R 4,R 5,R 6,R 7,n和虚线取允许的含义可以从id科,亚科, 本发明还提供其衍生物。
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公开(公告)号:US20100216817A1
公开(公告)日:2010-08-26
申请号:US11913513
申请日:2006-05-03
申请人: José Fernando Reyes Benitez , Maria del Carmen Cuevas Marchante , David Montalvo Lobo , Maria-Jesús Martin López , Maria Cristina Mateo Urbano , Andrés Francesch Solloso
发明人: José Fernando Reyes Benitez , Maria del Carmen Cuevas Marchante , David Montalvo Lobo , Maria-Jesús Martin López , Maria Cristina Mateo Urbano , Andrés Francesch Solloso
IPC分类号: A61K31/505 , C07D239/06 , A61P35/00
CPC分类号: C07D239/06
摘要: Antitumoral compounds of the formula (I) wherein X is O, S, or NRa, obtained from a maze coral of the family Meandrinidae, genus Meandrina, species meandrites, or derivatives thereof are useful as antitumoral agents.
摘要翻译: 由Meandrinidae,Meandrina,Meandrina,或其衍生物的迷宫珊瑚获得的式(I)的式(I)的抗肿瘤化合物可用作抗肿瘤剂。
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公开(公告)号:US20130066067A1
公开(公告)日:2013-03-14
申请号:US13699052
申请日:2011-05-24
IPC分类号: C07D515/22 , C07D471/18
CPC分类号: C07D515/22
摘要: This invention relates to compounds of formula II: wherein R1, R2, ProtSH, and ProtNH are as defined, to processes for the synthesis of ecteinascidins of formula I from compounds of formula II, and to processes for the synthesis of compounds of formula II.
摘要翻译: 本发明涉及式II化合物:其中R1,R2,ProtSH和ProtNH如上定义,用于从式II的化合物合成式I的海鞘糖苷的方法,以及用于合成式II化合物的方法。
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