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公开(公告)号：US20090170072A1
公开(公告)日：2009-07-02
申请号：US12350488
申请日：2009-01-08
IPC分类号： C12Q1/70 , G01N33/558 , G01N33/53
CPC分类号： A61B10/0051 , A61B2010/0006 , G01N30/90 , Y10S435/974 , Y10S436/81
摘要： A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. A bite plate is coupled to the housing and insertable between the teeth of the patient to position the porous wick in the oral cavity for collecting the oral fluid. The bite plate is typically held in place by the occlusal force of the teeth, preferably the molars and/or the bicuspids, to position the porous wick in the buccal space. By observing the lateral chromatographic strip while the test device is in the mouth immediate test results are obtained.
摘要翻译： 公开了一种用于将含水流体从口腔收集和输送到用于测试的侧向色谱条的装置。 侧向色谱条放置在限定在壳体中的空腔内并沿其延伸。 提供至少一个侧向色谱条的检查位置，以便检查侧向色谱条上的选定位点以便测试结果。 多孔芯材料在一端从外壳突出到外壳的收集位置，并在另一端与侧向色谱条连通。 多孔芯材料具有颗粒结构，颗粒吸附口腔液体，以将流体从嘴部输送到侧向色谱条而无需实质吸收。 多孔芯材料的颗粒被结合在一起以限定用于要输送的口腔液体的流动的连续间隙体积，并被处理为与吸附的口腔液体亲水。 多孔芯材料容易地将口腔液体释放到侧向色谱条上。 由于多孔芯材料的迂回流动路径，防止从侧向色谱条带逆向流入口腔。 咬合板联接到壳体并且可插入患者的牙齿之间，以将多孔芯放置在口腔中以收集口腔液体。 咬合板通常通过牙齿的咬合力（优选地为臼齿和/或双尖牙）保持在适当的位置，以将多孔芯放置在口腔空间中。 在测试装置处于口中时，通过观察侧向色谱条即可得到结果。
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公开(公告)号：US20120149124A1
公开(公告)日：2012-06-14
申请号：US13301067
申请日：2011-11-21
IPC分类号： G01N30/90
CPC分类号： A61B10/0051 , A61B2010/0006 , G01N30/90 , Y10S435/974 , Y10S436/81
摘要： A method and a device for collection and assay of oral fluids are disclosed. The method places an assay device into an oral cavity, removes the device, and determines the presence or absence of an analyte. The assay device comprises an assay portion housing a lateral flow assay strip, a neck portion extending from the assay portion and forming a channel for fluid delivery to the assay strip; a collection strip in fluid communication with the lateral flow assay strip; and a blocking strip coupled between and in flow communication with the lateral flow assay strip and the collection strip. The channel is defined by a narrow part proximal to the assay portion and a part which receives oral fluid and has a substantially wider channel width. The collection strip has a first portion disposed within the channel and a second portion protruding outwardly from the neck opening.
摘要翻译： 公开了用于收集和测定口腔液体的方法和装置。 该方法将测定装置放入口腔，去除装置，并确定分析物的存在或不存在。 测定装置包括容纳侧流测定条的测定部分，从测定部分延伸的颈部，并形成用于流体输送到测定条的通道; 与侧流测定条流体连通的收集条; 以及连接在侧流测定条和收集条之间并与其流动连通的阻挡条。 通道由靠近测定部分的狭窄部分和接收口腔液体的部分限定，并且具有基本更宽的通道宽度。 收集带具有设置在通道内的第一部分和从颈部开口向外突出的第二部分。
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