公开(公告)号：US08611992B2

公开(公告)日：2013-12-17

申请号：US13541641

申请日：2012-07-03

申请人： Andrew S. Goldstein ,  Frank Bellizzi

发明人： Andrew S. Goldstein ,  Frank Bellizzi

IPC分类号： A61B5/00

CPC分类号： A61B5/4875 ,  A61B5/4277 ,  A61B5/4848 ,  A61B5/682 ,  A61B10/0051 ,  A61B2562/0209 ,  A61B2562/029 ,  G01N33/48707

摘要： Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.

摘要翻译： 在预定体积容量的液体收集元件中收集唾液的定时感测可以用于确定唾液分泌速率，这可以指示脱水或脱水的状态。 通过感测唾液中至少一种分析物的浓度（例如，通过在侧流装置中进行的免疫色谱测定）来进一步增强唾液流速的感测，以确定脱水或脱水的状态。 可以刺激唾液的产生，并且可以分析收集的唾液以产生指示所收集的唾液中至少一种分析物的浓度的存在和/或相关性的分析物检测信号，以感测脱水或脱水的状态。

公开(公告)号：US07544468B2

公开(公告)日：2009-06-09

申请号：US09983735

申请日：2001-10-25

申请人： Andrew S. Goldstein ,  Richard K. Bestwick

发明人： Andrew S. Goldstein ,  Richard K. Bestwick

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6806 ,  C12N15/1006 ,  C12Q1/6883 ,  C12Q1/703 ,  C12Q2600/156 ,  Y10S436/811 ,  Y10T436/10 ,  Y10T436/107497 ,  Y10T436/2525 ,  Y10T436/25375 ,  C12Q2565/625

摘要： This invention provides for a rapid and convenient method of simultaneous collection of both genomic and diagnostic information from a single sample on a bibulous pad by differential extraction of the diagnostic information from the genomic information. It is a surprising discovery of this invention that a PCR assay on the contents of the bibulous pad provides results comparable in reliability, specificity, and sensitivity to the best available serum (blood) based assays. The assays of this invention can be used to confirm each other, either by detecting the genomic information leading to the diagnostic information, or by detecting in the genomic information, a predisposition to a disease and confirming the presence of the disease through diagnostic testing.

公开(公告)号：US07192555B2

公开(公告)日：2007-03-20

申请号：US09973956

申请日：2001-10-11

申请人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

发明人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

IPC分类号： G01N33/558

CPC分类号： A61B10/0051 ,  A61B2010/0006 ,  G01N30/90 ,  Y10S435/974 ,  Y10S436/81 ,  Y10T436/25

摘要： A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. A bite plate is coupled to the housing and insertable between the teeth of the patient to position the porous wick in the oral cavity for collecting the oral fluid. The bite plate is typically held in place by the occlusal force of the teeth, preferably the molars and/or the bicuspids, to position the porous wick in the buccal space. By observing the lateral chromatographic strip while the test device is in the mouth immediate test results are obtained.

公开(公告)号：US5073482A

公开(公告)日：1991-12-17

申请号：US209373

申请日：1988-06-21

申请人： Andrew S. Goldstein

发明人： Andrew S. Goldstein

IPC分类号： C12Q1/68 ,  C12Q1/70 ,  G01N15/08

CPC分类号： G01N15/08 ,  C12Q1/6888 ,  C12Q1/70

摘要： A device for testing an elastic membrane for permeability ot submicroscopic particles. The device has a first chamber to contain the particles in a fluid medium; a second chamber to contain a reagent for detecting the presence of any of the particles; suitable structure for mounting the membrane between the chambers in a fluid-tight manner so that the membrane separates the chambers; and a mechanism for applying stress to the membrane.

摘要翻译： 用于测试弹性膜用于亚显微粒子的渗透性的装置。 该装置具有第一室以将颗粒容纳在流体介质中; 第二室，容纳用于检测任何颗粒的存在的试剂; 用于以流体密封的方式将膜安装在室之间的适当结构，使得膜分离室; 以及向膜施加应力的机构。

公开(公告)号：US08326412B2

公开(公告)日：2012-12-04

申请号：US13249521

申请日：2011-09-30

申请人： Andrew S. Goldstein ,  Frank Bellizzi

发明人： Andrew S. Goldstein ,  Frank Bellizzi

IPC分类号： A61B5/05

CPC分类号： A61B5/4875 ,  A61B5/4277 ,  A61B5/4848 ,  A61B5/682 ,  A61B10/0051 ,  A61B2562/0209 ,  A61B2562/029 ,  G01N33/48707

摘要： Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.

摘要翻译： 在预定体积容量的液体收集元件中收集唾液的定时感测可以用于确定唾液分泌速率，这可以指示脱水或脱水的状态。 通过感测唾液中至少一种分析物的浓度（例如，通过在侧流装置中进行的免疫色谱测定）来进一步增强唾液流速的感测，以便确定脱水或脱水的状态。 可以刺激唾液的产生，并且可以分析收集的唾液以产生指示所收集的唾液中至少一种分析物的浓度的存在和/或相关性的分析物检测信号，以感测脱水或脱水的状态。

公开(公告)号：US08062908B2

公开(公告)日：2011-11-22

申请号：US12350488

申请日：2009-01-08

申请人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

发明人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

IPC分类号： G01N33/53

CPC分类号： A61B10/0051 ,  A61B2010/0006 ,  G01N30/90 ,  Y10S435/974 ,  Y10S436/81

摘要： A method for rapid collection and assay of oral fluids is disclosed. The method comprising the steps of: (a) placing an assay device into an oral cavity, (b) removing said assay device from said oral cavity; and (c) determining the presence or absence of at least one analyte. The assay device used in the method comprises: (i) an assay portion housing an immunochrornatographic lateral flow assay strip, the lateral flow assay strip containing at least one reagent selected from an antigen and an antibody that is used to detect one of the presence or absence of at least one analyte in a fluid; (ii) a neck portion extending from the assay portion, the neck portion forming a channel for delivery of fluid to said assay strip and the channel being defined by a first, narrow part proximal to the assay portion and a second part including an opening for receiving the oral fluid, wherein the second part includes a channel width that is substantially wider than the channel width at the narrow end; (iii) a collection strip in fluid communication with the lateral flow assay strip, the collection strip having a first portion disposed within the channel and a second portion protruding outwardly from the neck portion opening; and (iv) a blocking strip coupled between and in flow communication with the lateral flow assay strip and the collection strip.

摘要翻译： 公开了一种用于快速收集和测定口腔液体的方法。 该方法包括以下步骤：（a）将测定装置放入口腔，（b）从所述口腔中除去所述测定装置; 和（c）确定至少一种分析物的存在或不存在。 该方法中使用的测定装置包括：（i）容纳免疫色谱横向测定条的测定部分，所述侧流测定条含有至少一种选自抗原和抗体的试剂，所述试剂用于检测其中的一种存在或 在流体中不存在至少一种分析物; （ii）从分析部分延伸的颈部，颈部形成用于将流体输送到所述测定条的通道，并且所述通道由靠近测定部分的第一窄部分限定，第二部分包括用于 接收所述口腔流体，其中所述第二部分包括基本上宽于所述狭窄端处的通道宽度的通道宽度; （iii）与所述侧流测定条流体连通的收集条，所述收集条具有设置在所述通道内的第一部分和从所述颈部开口向外突出的第二部分; 和（iv）连接在侧流测定条和收集条之间并与其流动连通的阻挡条。

公开(公告)号：US20100239458A1

公开(公告)日：2010-09-23

申请号：US12544333

申请日：2009-08-20

申请人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

发明人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

IPC分类号： G01N30/88 ,  G01N31/22

CPC分类号： G01N33/558 ,  B01L3/5023 ,  B01L2300/0825 ,  B01L2300/12 ,  B01L2400/0406 ,  G01N30/91

摘要： An apparatus and process for transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. A lateral chromatographic strip is placed within a cavity defined in a housing. The lateral chromatography strip extends within the cavity and is disposed along the housing to an inspection site. At least one inspection site to the lateral chromate phic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. This porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. By observing the lateral chromatographic strip while the entire test device is in the mouth immediate test results are obtained.

摘要翻译： 公开了一种用于将水性流体从口腔输送到用于测试的侧向色谱条的装置和方法。 侧向色谱条被放置在限定在壳体中的空腔内。 侧向色谱条在腔内延伸并且沿着壳体设置到检查位置。 提供至少一个侧向铬酸盐条带的检查部位，以便检查侧向色谱条上的选定部位以进行测试。 多孔芯材料在一端从外壳突出到外壳的收集位置，并在另一端与侧向色谱条连通。 该多孔芯材料具有颗粒结构，该颗粒吸附口腔液体水以将流体从嘴部输送到侧向色谱条而无需实质的吸收。 多孔芯材料的颗粒被结合在一起以限定用于要输送的口腔液体的流动的连续间隙体积，并被处理为与吸附的口腔液体亲水。 多孔芯材料容易地将口腔液体释放到侧向色谱条上。 由于多孔芯材料的迂回流动路径，防止从侧向色谱条带逆向流入口腔。 通过在整个测试装置处于口中立即测试结果，观察侧向色谱条。

公开(公告)号：US06309827B1

公开(公告)日：2001-10-30

申请号：US09049714

申请日：1998-03-27

申请人： Andrew S. Goldstein ,  Richard K. Bestwick

发明人： Andrew S. Goldstein ,  Richard K. Bestwick

IPC分类号： C12G168

CPC分类号： C12Q1/6806 ,  C12N15/1006 ,  C12Q1/6883 ,  C12Q1/703 ,  C12Q2600/156 ,  Y10S436/811 ,  Y10T436/10 ,  Y10T436/107497 ,  Y10T436/2525 ,  Y10T436/25375 ,  C12Q2565/625

摘要： This invention provides for a rapid and convenient method of simultaneous collection of both genomic and diagnostic information from a single sample on a bibulous pad by differential extraction of the diagnostic information from the genomic information. It is a surprising discovery of this invention that a PCR assay on the contents of the bibulous pad provides results comparable in reliability, specificity, and sensitivity to the best available serum (blood) based assays. The assays of this invention can be used to confirm each other, either by detecting the genomic information leading to the diagnostic information, or by detecting in the genomic information, a predisposition to a disease and confirming the presence of the disease through diagnostic testing.

摘要翻译： 本发明提供了一种通过从基因组信息中差异提取诊断信息来同时收集来自吸收垫上的单个样品的基因组和诊断信息的快速和方便的方法。 对本发明的令人惊讶的发现是，针对吸水垫的内容物的PCR测定提供了与基于最佳可用血清（血液）测定法的可靠性，特异性和灵敏度相当的结果。 本发明的测定可以通过检测导致诊断信息的基因组信息，或者通过在基因组信息中检测疾病的易感性并通过诊断测试来确认疾病的存在来用于彼此确认。

公开(公告)号：US5830410A

公开(公告)日：1998-11-03

申请号：US456459

申请日：1995-06-01

申请人： Thomas R. Thieme ,  Andrew S. Goldstein ,  Stephen C. Piacentini ,  Nanette M. Klimkow

发明人： Thomas R. Thieme ,  Andrew S. Goldstein ,  Stephen C. Piacentini ,  Nanette M. Klimkow

IPC分类号： G01N33/48 ,  A61B5/00 ,  A61B10/00 ,  A61B10/02 ,  B01L3/00 ,  G01N1/14 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/68 ,  G01N33/487

CPC分类号： G01N33/5302 ,  A61B10/0051 ,  B01L3/502 ,  G01N33/54366 ,  G01N33/569 ,  G01N33/56988 ,  G01N33/68 ,  G01N33/6854 ,  A61B2010/0003 ,  A61B2010/0009 ,  G01N2001/149

摘要： A device for obtaining oral fluid containing substances for testing. In one embodiment, the device includes a syringe having a plunger at the end of which an absorbent pad is attached. A test assembly containing the device is also disclosed.

摘要翻译： 一种用于获得含有测试物质的口腔液的装置。 在一个实施例中，该装置包括具有柱塞的注射器，其末端附接有吸收垫。 还公开了一种包含该装置的测试组件。

公开(公告)号：US5112758A

公开(公告)日：1992-05-12

申请号：US192015

申请日：1988-05-09

申请人： Jack H. Fellman ,  Andrew S. Goldstein

发明人： Jack H. Fellman ,  Andrew S. Goldstein

IPC分类号： G01N33/483 ,  G01N33/50

CPC分类号： G01N33/50 ,  Y10T436/10 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25 ,  Y10T436/2525 ,  Y10T436/25625

摘要： A method of reducing the viscosity of a body fluid comprises mixing a body fluid with a cationic quaternary ammonium reagent. The body fluid is a mucopolysaccharide-containing body fluid which will be tested for a metabolite.

摘要翻译： 降低体液粘度的方法包括将体液与阳离子季铵试剂混合。 体液是含有粘多糖的体液，将被测试代谢物。