公开(公告)号：US20100305192A1

公开(公告)日：2010-12-02

申请号：US12789564

申请日：2010-05-28

申请人： SAMEER GOREGAOKER ,  JOHN C. HUNTER ,  TONY PRIESTLEY

发明人： SAMEER GOREGAOKER ,  JOHN C. HUNTER ,  TONY PRIESTLEY

IPC分类号： A61K31/7088 ,  C07H21/04 ,  C07H21/00 ,  A61P29/00 ,  C12N15/63 ,  C12N5/071

CPC分类号： C12N15/113 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/14

摘要： The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Nav1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.

摘要翻译： 本发明提供短链干扰核酸，单链或双链，其导致RNAi诱导的来自Nav1.8钠通道基因的mRNA降解; 涉及包含这种短干扰核酸的药物组合物; 包含这种短干扰核酸的重组载体; 抑制mRNA翻译的方法; 抑制多肽表达的方法; 阻断细胞膜电位的方法; 阻止细胞中钠电流的方法; 和抑制慢性疼痛的方法。