公开(公告)号：US20150203501A1

公开(公告)日：2015-07-23

申请号：US14525861

申请日：2014-10-28

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： H. Scott WILKINSON ,  Richard HSIA ,  Tushar MISRA ,  Kostas SARANTEAS ,  Patrick MOUSAW

IPC: C07D487/04 ,  C07C57/145

CPC classification number: C07D487/04 ,  C07C57/145

Abstract: A novel maleate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4 -b]吡嗪）。

公开(公告)号：US20130296565A1

公开(公告)日：2013-11-07

申请号：US13932324

申请日：2013-07-01

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： H. Scott WILKINSON ,  Richard HSIA ,  Tushar MISRA ,  Kostas SARANTEAS ,  Patrick MOUSAW

IPC: C07D487/04 ,  C07C59/245

CPC classification number: C07D487/04 ,  C07C59/245

Abstract: A novel L-malate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3 ，4-b]吡嗪）。

公开(公告)号：US20220402937A1

公开(公告)日：2022-12-22

申请号：US17814378

申请日：2022-07-22

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Andrea BAUER ,  Nandkumar Nivritti BHOGLE ,  Xiaoxia CHEN ,  Shahla JAMZAD ,  Robert Joseph PRYTKO ,  Kostas SARANTEAS ,  Michael Joseph SIZENSKY ,  Harold Scott WILKINSON ,  Haitao ZHANG

IPC: C07D495/04 ,  A61P25/18 ,  A61K9/20 ,  A61K45/06 ,  A61K31/381 ,  A61P25/00

Abstract: Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.

公开(公告)号：US20210053983A1

公开(公告)日：2021-02-25

申请号：US17006101

申请日：2020-08-28

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Andrea BAUER ,  Nandkumar Nivritti BHOGLE ,  Xiaoxia CHEN ,  Shahla JAMZAD ,  Robert Joseph PRYTKO ,  Kostas SARANTEAS ,  Michael Joseph SIZENSKY ,  Harold Scott WILKINSON ,  Haitao ZHANG

IPC: C07D495/04 ,  A61P25/18 ,  A61K9/20 ,  A61K45/06 ,  A61K31/381 ,  A61P25/00

Abstract: Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.