公开(公告)号：US20150203501A1

公开(公告)日：2015-07-23

申请号：US14525861

申请日：2014-10-28

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： H. Scott WILKINSON ,  Richard HSIA ,  Tushar MISRA ,  Kostas SARANTEAS ,  Patrick MOUSAW

IPC: C07D487/04 ,  C07C57/145

CPC classification number: C07D487/04 ,  C07C57/145

Abstract: A novel maleate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4 -b]吡嗪）。

公开(公告)号：US20130289040A1

公开(公告)日：2013-10-31

申请号：US13928571

申请日：2013-06-27

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： H. Scott WILKINSON ,  Richard HSIA ,  Tushar MISRA ,  Kostas Saranteas ,  Patrick MOUSAW

IPC: C07D487/04

CPC classification number: C07D487/04 ,  C07C57/145

Abstract: A novel maleate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.

公开(公告)号：US20140271858A1

公开(公告)日：2014-09-18

申请号：US14243146

申请日：2014-04-02

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Richard HSIA ,  Cai Gu HUANG ,  Konstantinos E. SARANTEAS ,  Tushar K. MISRA ,  Philip J. BONASIA, JR.

IPC: A61K9/28 ,  A61K31/4985

CPC classification number: A61K9/2866 ,  A61K31/4985 ,  Y10T436/147777

Abstract: Coated tablets of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided. The tablets minimize the perceived bitterness of the medicament. A method for analyzing instantaneous dissolution of sub-microgram quantities of core material is also disclosed.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b ]吡嗪）。 片剂使药物的感觉到的苦味最小化。 还公开了一种用于分析亚微米数量的芯材料的瞬时溶解的方法。

公开(公告)号：US20130296565A1

公开(公告)日：2013-11-07

申请号：US13932324

申请日：2013-07-01

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： H. Scott WILKINSON ,  Richard HSIA ,  Tushar MISRA ,  Kostas SARANTEAS ,  Patrick MOUSAW

IPC: C07D487/04 ,  C07C59/245

CPC classification number: C07D487/04 ,  C07C59/245

Abstract: A novel L-malate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3 ，4-b]吡嗪）。