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公开(公告)号:US20150079112A1
公开(公告)日:2015-03-19
申请号:US14446199
申请日:2014-07-29
Applicant: Samsung Electronics Co., Ltd.
Inventor: Kyung Eun KIM , Sang Yeul Han , Gou Young Koh , Hyo Seon Lee , Chan Kim
CPC classification number: C07K16/28 , A61K38/17 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/32 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/77 , C07K2317/92
Abstract: A method of preventing or treating cancer using an anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes to a Tie2 receptor while bound with Ang2.
Abstract translation: 使用Ang2抗体或其抗原结合片段预防或治疗癌症的方法,所述抗Ang2抗体或其抗原结合片段特异性结合血管发生诱导因子促血管生成素-2(Ang2),并与Ang2结合时与Tie2受体复合。
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公开(公告)号:US20150030603A1
公开(公告)日:2015-01-29
申请号:US14446228
申请日:2014-07-29
Applicant: Samsung Electronics Co., Ltd.
Inventor: Kyung Eun KIM , Seung Ja Oh , Hyo Seon Lee , Sang Yeul Han
IPC: C07K16/22 , A61K38/18 , G01N33/74 , A61K39/395
CPC classification number: C07K16/22 , A61K38/1891 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/515 , G01N2333/71 , G01N2500/02
Abstract: An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor and Ang2, and related methods and compositions.
Abstract translation: 特异性结合血管发生诱导因子促血管生成素-2(Ang2促血管素-2)和与Tie2受体和Ang2复合的抗Ang2抗体或其抗原结合片段,以及相关方法和组合物。
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公开(公告)号:US20150152192A1
公开(公告)日:2015-06-04
申请号:US14556911
申请日:2014-12-01
Applicant: Samsung Electronics Co., Ltd.
Inventor: Hyung-Chan KIM , Kyung Eun KIM , Yoon Sook LEE , Mi Young CHO
CPC classification number: C07K16/2863 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: An anti-c-Met/anti-Ang2 bispecific antibody, a composition including the anti-c-Met/anti-Ang2 bispecific antibody, and a method of preventing and/or treating a cancer in a subject including administering the anti-c-Met/anti-Ang2 bispecific antibody to the subject.
Abstract translation: 抗c-Met /抗Ang2双特异性抗体,包含抗c-Met /抗Ang2双特异性抗体的组合物,以及预防和/或治疗受试者的癌症的方法,包括给予抗c- Met /抗Ang2双特异性抗体。
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公开(公告)号:US20150110787A1
公开(公告)日:2015-04-23
申请号:US14518502
申请日:2014-10-20
Applicant: Samsung Electronics Co., Ltd.
Inventor: Seok Kyun KIM , Sang Yeul HAN , Kwang Hoon LEE , Kyung Eun KIM
IPC: C07K16/22
CPC classification number: C07K16/22 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: A polypeptide, antagonist, and antibody that specifically bind to and inhibit VEGF-C and uses thereof in a method of inhibiting angiogenesis and a method of preventing, treating, and/or diagnosing a disease associated with activation and/or overexpression of VEGF-C, using the antibody, and a method of detecting the presence of VEGF-C in a sample.
Abstract translation: 特异性结合并抑制VEGF-C的多肽,拮抗剂和抗体及其在抑制血管发生的方法中的用途以及预防,治疗和/或诊断与VEGF-C的活化和/或过表达相关的疾病的方法 ,以及检测样品中VEGF-C存在的方法。
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