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公开(公告)号：US20090104279A1
公开(公告)日：2009-04-23
申请号：US12055511
申请日：2008-03-26
申请人： Sebastian BARRADEAU , Eckart BARTNIK , Joerg CZECH , Andreas R. Klatt , Ekkehard LEBERER , Thomas LEEUW
发明人： Sebastian BARRADEAU , Eckart BARTNIK , Joerg CZECH , Andreas R. Klatt , Ekkehard LEBERER , Thomas LEEUW
CPC分类号： A61K38/17 , C07K16/44 , Y10T436/143333
摘要： The invention refers to the use of a p21-activated kinase (PAK) inhibitor as a target protein for the discovery of a PAK inhibitor as a medicament for the treatment of a joint disease.
摘要翻译： 本发明涉及使用p21激活的激酶（PAK）抑制剂作为靶蛋白，用于发现PAK抑制剂作为治疗关节疾病的药物。
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公开(公告)号：US08187828B2
公开(公告)日：2012-05-29
申请号：US12055511
申请日：2008-03-26
申请人： Sebastian Barradeau , Eckart Bartnik , Joerg Czech , Andreas R. Klatt , Ekkehard Leberer , Thomas Leeuw
发明人： Sebastian Barradeau , Eckart Bartnik , Joerg Czech , Andreas R. Klatt , Ekkehard Leberer , Thomas Leeuw
CPC分类号： A61K38/17 , C07K16/44 , Y10T436/143333
摘要： The invention refers to the use of a p21-activated kinase (PAK) inhibitor as a target protein for the discovery of a PAK inhibitor as a medicament for the treatment of a joint disease.
摘要翻译： 本发明涉及使用p21激活的激酶（PAK）抑制剂作为靶蛋白，用于发现PAK抑制剂作为治疗关节疾病的药物。
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公开(公告)号：US07364887B2
公开(公告)日：2008-04-29
申请号：US10893025
申请日：2004-07-16
申请人： Sebastian Barradeau , Eckart Bartnik , Joerg Czech , Andreas R. Klatt , Ekkehard Leberer , Thomas Leeuw
发明人： Sebastian Barradeau , Eckart Bartnik , Joerg Czech , Andreas R. Klatt , Ekkehard Leberer , Thomas Leeuw
CPC分类号： A61K38/17 , C07K16/44 , Y10T436/143333
摘要： The invention refers to the use of a p21-activated kinase (PAK) inhibitor for the treatment of a joint disease such as osteoarthritis or rheumatoid arthritis or for the treatment of a joint pain and the use of PAK as a target protein for the discovery of a PAK inhibitor as a medicament for the treatment of a joint disease.
摘要翻译： 本发明涉及使用p21激活的激酶（PAK）抑制剂来治疗关节疾病如骨关节炎或类风湿性关节炎或用于治疗关节疼痛，以及使用PAK作为靶蛋白来发现 PAK抑制剂作为治疗关节疾病的药物。
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