公开(公告)号：US20120004443A1

公开(公告)日：2012-01-05

申请号：US13255168

申请日：2010-06-25

Applicant: Shinki Tani

Inventor： Shinki Tani

IPC: C07C67/10

CPC classification number: C07C69/716 ,  C07C67/31 ,  C07C67/313 ,  C07C69/675

Abstract: Disclosed is a process for the production of ketomalonic acid compounds or hydrates thereof by reacting a malonic acid compound with one or more chlorous acid compounds selected from among chlorous acid and chlorites and thus oxidizing the methylene group of the malonic acid compound. The process does not necessitate highly toxic reagents, lowly safe reagents, special reactants, special reaction equipment, expensive reagents, expensive catalysts, or transition metals such as noble metals, and permits the selection of mild reaction conditions and simple operation, thus enabling efficient and easy production of ketomalonic acid compounds such as ketomalonic diesters under simple and easy conditions suitable for industrialization.

Abstract translation: 公开了通过使丙二酸化合物与一种或多种选自亚氯酸盐和亚氯酸盐中的亚氯酸化合物反应并因此氧化丙二酸化合物的亚甲基基团来生产酮咯酸化合物或其水合物的方法。 该方法不需要高毒性试剂，低安全性试剂，特殊反应物，特殊反应设备，昂贵的试剂，昂贵的催化剂或过渡金属如贵金属，并且允许选择温和的反应条件和简单的操作，从而使得有效和 在易于工业化的简单条件下容易地生产酮醛酸化合物如酮缩二酯。

公开(公告)号：US20140163256A1

公开(公告)日：2014-06-12

申请号：US14131106

申请日：2012-07-04

Applicant: Shinki Tani ,  Nami Yadomatsu ,  Akiko Ikumi ,  Yuuki Hirano ,  Takuya Ido

Inventor： Shinki Tani ,  Nami Yadomatsu ,  Akiko Ikumi ,  Yuuki Hirano ,  Takuya Ido

IPC: C07C201/06

CPC classification number: C07C201/06 ,  C07C205/06 ,  C07C205/58

Abstract: A method for producing a nitrobenzene compound represented by general formula (2), wherein R1 and R5 are the same or different, and each is a halogen atom or another functional group, and R2, R3, and R4 are the same or different, and each is a hydrogen atom or another functional group, comprises oxidizing an aniline compound represented by general formula (1), wherein R1, R2, R3, R4, and R5 are the same as described above, with hydrogen peroxide in the presence of a tungsten compound under an acidic condition, followed by oxidation with hydrogen peroxide under a neutral to alkaline condition.

Abstract translation: 一种制备由通式（2）表示的硝基苯化合物的方法，其中R1和R5相同或不同，并且各自为卤素原子或其它官能团，R2，R3和R4相同或不同， 各自为氢原子或另一官能团，包括将氧化由通式（1）表示的苯胺化合物，其中R1，R2，R3，R4和R5与上述相同，与过氧化氢在钨存在下 在酸性条件下，然后在中性至碱性条件下用过氧化氢氧化。

公开(公告)号：US09006477B2

公开(公告)日：2015-04-14

申请号：US14131106

申请日：2012-07-04

Applicant: Shinki Tani ,  Nami Yadomatsu ,  Akiko Ikumi ,  Yuuki Hirano ,  Takuya Ido

Inventor： Shinki Tani ,  Nami Yadomatsu ,  Akiko Ikumi ,  Yuuki Hirano ,  Takuya Ido

IPC: C07C205/06 ,  C07C201/06

CPC classification number: C07C201/06 ,  C07C205/06 ,  C07C205/58

Abstract: A method for producing a nitrobenzene compound represented by general formula (2),wherein R1 and R5 are the same or different, and each is a halogen atom or another functional group, and R2, R3, and R4 are the same or different, and each is a hydrogen atom or another functional group, comprises oxidizing an aniline compound represented by general formula (1), wherein R1, R2, R3, R4, and R5 are the same as described above, with hydrogen peroxide in the presence of a tungsten compound under an acidic condition, followed by oxidation with hydrogen peroxide under a neutral to alkaline condition.

Abstract translation: 一种制备由通式（2）表示的硝基苯化合物的方法，其中R1和R5相同或不同，并且各自为卤素原子或其它官能团，R2，R3和R4相同或不同， 各自为氢原子或另一官能团，包括将氧化由通式（1）表示的苯胺化合物，其中R1，R2，R3，R4和R5与上述相同，与过氧化氢在钨存在下 在酸性条件下，然后在中性至碱性条件下用过氧化氢氧化。

公开(公告)号：US08859803B2

公开(公告)日：2014-10-14

申请号：US13255168

申请日：2010-06-25

Applicant: Shinki Tani

Inventor： Shinki Tani

IPC: C07C67/313 ,  C07C67/31 ,  C07C69/716 ,  C07C69/675

CPC classification number: C07C69/716 ,  C07C67/31 ,  C07C67/313 ,  C07C69/675

Abstract: Disclosed is a process for the production of ketomalonic acid compounds or hydrates thereof by reacting a malonic acid compound with one or more chlorous acid compounds selected from among chlorous acid and chlorites and thus oxidizing the methylene group of the malonic acid compound. The process does not necessitate highly toxic reagents, lowly safe reagents, special reactants, special reaction equipment, expensive reagents, expensive catalysts, or transition metals such as noble metals, and permits the selection of mild reaction conditions and simple operation, thus enabling efficient and easy production of ketomalonic acid compounds such as ketomalonic diesters under simple and easy conditions suitable for industrialization.

Abstract translation: 公开了通过使丙二酸化合物与一种或多种选自亚氯酸盐和亚氯酸盐中的亚氯酸化合物反应并因此氧化丙二酸化合物的亚甲基基团来生产酮咯酸化合物或其水合物的方法。 该方法不需要高毒性试剂，低安全性试剂，特殊反应物，特殊反应设备，昂贵的试剂，昂贵的催化剂或过渡金属如贵金属，并且允许选择温和的反应条件和简单的操作，从而使得有效和 在易于工业化的简单条件下容易地生产酮醛酸化合物如酮缩二酯。