公开(公告)号：US20100190999A1

公开(公告)日：2010-07-29

申请号：US12359467

申请日：2009-01-26

申请人： Shriprakash Dhar DWIVEDI ,  Dhimant Jasubhai Patel ,  Kishor Maneklal Vinchhi ,  Mahesh Laljibhai Rupapara

发明人： Shriprakash Dhar DWIVEDI ,  Dhimant Jasubhai Patel ,  Kishor Maneklal Vinchhi ,  Mahesh Laljibhai Rupapara

IPC分类号： C07D207/34

CPC分类号： C07D207/34

摘要： The present invention also provides the amorphous form of hemi-calcium salt of atorvastatin with high purity and processes for preparation thereof.

摘要翻译： 本发明还提供了高纯度的阿托伐他汀半钙盐的无定形形式及其制备方法。

公开(公告)号：US08115015B2

公开(公告)日：2012-02-14

申请号：US12359467

申请日：2009-01-26

申请人： Shriprakash Dhar Dwivedi ,  Dhimant Jasubhai Patel ,  Kishor Maneklal Vinchhi ,  Mahesh Laljibhai Rupapara

发明人： Shriprakash Dhar Dwivedi ,  Dhimant Jasubhai Patel ,  Kishor Maneklal Vinchhi ,  Mahesh Laljibhai Rupapara

IPC分类号： C07D207/00

CPC分类号： C07D207/34

摘要： The present invention also provides the amorphous form of hemi-calcium salt of atorvastatin with high purity and processes for preparation thereof.

摘要翻译： 本发明还提供了高纯度的阿托伐他汀半钙盐的无定形形式及其制备方法。

公开(公告)号：US08759518B2

公开(公告)日：2014-06-24

申请号：US13576296

申请日：2011-02-23

申请人： Shriprakash Dhar Dwivedi ,  Dhimant Jasubhai Patel ,  Mahesh Laljibhai Rupapara

发明人： Shriprakash Dhar Dwivedi ,  Dhimant Jasubhai Patel ,  Mahesh Laljibhai Rupapara

IPC分类号： C07D239/02 ,  C07D405/12 ,  C07D239/42 ,  C07D405/06 ,  C07D257/04

CPC分类号： C07D405/12 ,  C07D239/42 ,  C07D257/04 ,  C07D405/06 ,  Y02P20/55

摘要： A compound of Formula (1), is disclosed wherein P1 and P2 are alcohol protecting groups or 1,3-diol protecting group, R is selected from: wherein R4a is selected from alkyl, aryl, arylalkyl and cycloalkyl, Rc is selected from H, alkyl, aryl, alkaoxy, haloalkyl, monohaloalkyloxy, and dihaloalkyloxy, Rd is selected from alkyl, aryl, arylalkyl, CF3, halo and NO2 and X is selected from O, N—H, N-alkyl and S, Ra and Rb are same or different and each represents hydrogen, an alkyl group of 1 to 12 carbon atoms, an aryl group of 6 to 12 carbon atoms, or an aralkyl group of 7 to 12 carbon atoms.

摘要翻译： 公开了式（1）的化合物，其中P1和P2是醇保护基或1,3-二醇保护基，R选自：其中R 4a选自烷基，芳基，芳烷基和环烷基，R c选自H 烷基，芳基，烷氧基，卤代烷基，单卤代烷氧基和二卤烷氧基，Rd选自烷基，芳基，芳基烷基，CF 3，卤素和NO 2，X选自O，N-H，N-烷基和S， 相同或不同，各自表示氢，1至12个碳原子的烷基，6至12个碳原子的芳基或7至12个碳原子的芳烷基。

公开(公告)号：US20130158263A1

公开(公告)日：2013-06-20

申请号：US13576296

申请日：2011-02-23

申请人： Shriprakash Dhar Dwivedi ,  Dhimant Jasubhai Patel ,  Mahesh Laljibhai Rupapara

发明人： Shriprakash Dhar Dwivedi ,  Dhimant Jasubhai Patel ,  Mahesh Laljibhai Rupapara

IPC分类号： C07D405/12 ,  C07D405/06 ,  C07D239/42 ,  C07D257/04

CPC分类号： C07D405/12 ,  C07D239/42 ,  C07D257/04 ,  C07D405/06 ,  Y02P20/55

摘要： A compound of Formula (1), is disclosed wherein P1 and P2 are alcohol protecting groups or 1,3-diol protecting group, R is selected from: wherein R4a is selected from alkyl, aryl, arylalkyl and cycloalkyl, Rc is selected from H, alkyl, aryl, alkaoxy, haloalkyl, monohaloalkyloxy, and dihaloalkyloxy, Rd is selected from alkyl, aryl, arylalkyl, CF3, halo and NO2 and X is selected from O, N—H, N-alkyl and S, Ra and Rb are same or different and each represents hydrogen, an alkyl group of 1 to 12 carbon atoms, an aryl group of 6 to 12 carbon atoms, or an aralkyl group of 7 to 12 carbon atoms.

摘要翻译： 公开了式（1）的化合物，其中P1和P2是醇保护基或1,3-二醇保护基，R选自：其中R 4a选自烷基，芳基，芳烷基和环烷基，R c选自H 烷基，芳基，烷氧基，卤代烷基，单卤代烷氧基和二卤烷氧基，Rd选自烷基，芳基，芳基烷基，CF 3，卤素和NO 2，X选自O，NH，N-烷基和S，R a和R b相同或 各自表示氢，1〜12个碳原子的烷基，6〜12个碳原子的芳基或7〜12个碳原子的芳烷基。