公开(公告)号：US4960883A

公开(公告)日：1990-10-02

申请号：US310683

申请日：1989-02-15

申请人： Sohei Tanabe ,  Seiichi Sato ,  Yoshinori Kyotani ,  Tomio Ohta ,  Yasumi Uchida

发明人： Sohei Tanabe ,  Seiichi Sato ,  Yoshinori Kyotani ,  Tomio Ohta ,  Yasumi Uchida

IPC分类号： C07D295/18 ,  A61K31/47 ,  A61K31/472 ,  A61K31/495 ,  A61K31/55 ,  A61P9/00 ,  C07D217/02 ,  C07D243/08 ,  C07D295/192 ,  C07D295/22 ,  C07D295/26

CPC分类号： C07D295/192 ,  C07D217/02 ,  C07D295/26

摘要： A propane derivative represented by the following formula ##STR1## wherein R represents a lower alkyl group; one of A and B represents a group of the formula ##STR2## and the other represents a group of the formula ##STR3## in which R.sup.1 and R.sup.2 are identical or different and each represents a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, R.sup.3 represents a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group, and X represents a sulfonyl group or a carbonyl group,and an acid addition salt thereof. The compounds provided by this invention have useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular diseases such as angina pectoris, cerebral circulation disorder and thrombosis.

公开(公告)号：US4948892A

公开(公告)日：1990-08-14

申请号：US310684

申请日：1989-02-15

申请人： Sohei Tanabe ,  Seiichi Sato ,  Yoshinori Kyotani ,  Tomio Ohta ,  Yasumi Uchida

发明人： Sohei Tanabe ,  Seiichi Sato ,  Yoshinori Kyotani ,  Tomio Ohta ,  Yasumi Uchida

IPC分类号： C07D295/12 ,  A61K31/495 ,  A61P9/00 ,  C07D213/74 ,  C07D213/75 ,  C07D241/04 ,  C07D295/13

CPC分类号： C07D213/74 ,  C07D295/13

摘要： A sulfonamide compound represented by the following formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are identical or different, and each represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a hydrogen atom, a lower alkyl group, or a substituted or unsubstituted aralykyl group; R.sup.5 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group; R.sup.6 and R.sup.7 are identical or different and each represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; and n is an integer of 1 to 8,and an acid addition salt thereof. The compounds of formula (I) provided by this invention have some useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular disorders such as angina pectoris, cerebral circulation disorder and thrombosis.

公开(公告)号：US4530791A

公开(公告)日：1985-07-23

申请号：US137259

申请日：1980-04-04

申请人： Masahito Nakayama ,  Akio Iwasaki ,  Shigeru Kimura ,  Sohei Tanabe ,  Toshimi Mizoguchi ,  Akira Murakami ,  Isamu Watanabe ,  Masao Okuchi ,  Hisakatsu Ito ,  Toshihito Mori

发明人： Masahito Nakayama ,  Akio Iwasaki ,  Shigeru Kimura ,  Sohei Tanabe ,  Toshimi Mizoguchi ,  Akira Murakami ,  Isamu Watanabe ,  Masao Okuchi ,  Hisakatsu Ito ,  Toshihito Mori

IPC分类号： C07D477/20 ,  C12P17/18 ,  C07D487/04 ,  A61K31/40

CPC分类号： C07D477/20 ,  C12P17/184

摘要： A novel antibiotic designated as KA-6643 and having the formula, ##STR1## wherein R is hydrogen or --SO.sub.3 H.

摘要翻译： 一种称为KA-6643并具有下式的新型抗生素，其中R是氢或-SO 3 H。

公开(公告)号：US4468350A

公开(公告)日：1984-08-28

申请号：US314028

申请日：1981-10-22

申请人： Masao Okuchi ,  Masahito Nakayama ,  Akio Iwasaki ,  Shigeru Kimura ,  Toshimi Mizoguchi ,  Sohei Tanabe ,  Akira Murakami ,  Hisakatsu Ito ,  Toshihito Mori

发明人： Masao Okuchi ,  Masahito Nakayama ,  Akio Iwasaki ,  Shigeru Kimura ,  Toshimi Mizoguchi ,  Sohei Tanabe ,  Akira Murakami ,  Hisakatsu Ito ,  Toshihito Mori

IPC分类号： C07D477/20 ,  C12P17/18 ,  C07D487/04

CPC分类号： C07D477/20 ,  C12P17/184 ,  C12R1/465

摘要： A-KA-6643-series antibiotic comprising at least one substance represented by any of the following formulae, or a salt or ester thereof: ##STR1## is effectively useful as an antibacterial and .beta.-lactamase inhibiting agent.

摘要翻译： A-KA-6643系列抗生素，其包含至少一种由下式表示的物质或其盐或酯：（1）（2）（3）（ 4）有效用作抗菌和β-内酰胺酶抑制剂。

公开(公告)号：US4415497A

公开(公告)日：1983-11-15

申请号：US296306

申请日：1981-08-26

申请人： Masahito Nakayama ,  Shigeru Kimura ,  Toshimi Mizoguchi ,  Sohei Tanabe ,  Toshihito Mori

发明人： Masahito Nakayama ,  Shigeru Kimura ,  Toshimi Mizoguchi ,  Sohei Tanabe ,  Toshihito Mori

IPC分类号： C07D477/00 ,  C07D477/02 ,  C12P17/18 ,  C12R1/465 ,  C07D487/04

CPC分类号： C07D477/02

摘要： An antibiotic KA-6643-A or a salt thereof having the formula: ##STR1## is produced by a process comprising the step of hydrolyzing an antibiotic KA-6643-B of the formula: ##STR2##

摘要翻译： 通过包括水解下式的抗生素KA-6643-B的步骤的方法生产具有下式的抗生素KA-6643-A或其盐：