公开(公告)号：US5510366A

公开(公告)日：1996-04-23

申请号：US330670

申请日：1994-10-28

申请人： Yoshinori Kyotani ,  Katsumi Kawamine ,  Tsutomu Toma ,  Tadaaki Ohgiya ,  Takashi Yamaguchi ,  Kazuhiro Onogi ,  Seiichi Sato ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Tomio Ohta ,  Toshiaki Oda ,  Yukihiro Okuno ,  Kimiyuki Shibuya ,  Yoshio Takahashi ,  Mikio Fujii ,  Yasumi Uchida

发明人： Yoshinori Kyotani ,  Katsumi Kawamine ,  Tsutomu Toma ,  Tadaaki Ohgiya ,  Takashi Yamaguchi ,  Kazuhiro Onogi ,  Seiichi Sato ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Tomio Ohta ,  Toshiaki Oda ,  Yukihiro Okuno ,  Kimiyuki Shibuya ,  Yoshio Takahashi ,  Mikio Fujii ,  Yasumi Uchida

IPC分类号： C07D491/04 ,  C07D491/048 ,  A61K31/40 ,  C07D491/056

CPC分类号： C07D491/04

摘要： An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.

摘要翻译： 由式（1）表示的吲哚衍生物，本文R10为氢或低级烷基，虚线可以任选存在，R 1 -R 9表示各种取代基。 化合物（1）对心肌呈现正性肌力作用，抗心律失常作用和血管舒张作用而不增加心率。 包含该化合物作为有效成分的心脏治疗剂对于治疗心力衰竭和心律失常是非常有效的。

公开(公告)号：US5389630A

公开(公告)日：1995-02-14

申请号：US966142

申请日：1993-01-22

申请人： Seiichi Sato ,  Kiyoshi Kawamura ,  Yoshio Takahashi ,  Koichiro Watanabe ,  Sadahiro Shimizu ,  Tomio Ohta

发明人： Seiichi Sato ,  Kiyoshi Kawamura ,  Yoshio Takahashi ,  Koichiro Watanabe ,  Sadahiro Shimizu ,  Tomio Ohta

IPC分类号： A61K31/135 ,  A61K31/165 ,  A61K31/18 ,  A61K31/195 ,  A61K31/22 ,  A61K31/24 ,  A61K31/245 ,  A61K31/25 ,  A61K31/255 ,  A61K31/27 ,  A61K31/4164 ,  A61K31/495 ,  A61K31/55 ,  A61K31/551 ,  A61P25/28 ,  C07C211/09 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C211/49 ,  C07C235/50 ,  C07C237/04 ,  C07C271/28 ,  C07C275/28 ,  C07C275/34 ,  C07C309/65 ,  C07C311/18 ,  C07C311/29 ,  C07C311/41 ,  C07C327/26 ,  C07C327/28 ,  C07C327/30 ,  C07C327/32 ,  C07C327/34 ,  C07C327/36 ,  C07D243/08 ,  C07D295/04 ,  C07D295/06 ,  C07D295/08 ,  C07D295/12 ,  C07D295/13 ,  C07D295/14

CPC分类号： C07D295/13 ,  C07C211/27 ,  C07C211/49 ,  C07C237/04 ,  C07C271/28 ,  C07C275/34 ,  C07C311/29 ,  C07C327/30

摘要： Diamine compounds of formula (I) or an addition salt thereof are provided: ##STR1## These compounds have an excellent cerebral protective action, are very safe, and exhibit a strong action when orally administered, and therefore, medicines containing such compounds are effective for treating disorders caused by cerebral hemorrhage, cerebral infarction, subarachnoid hemorrhage, transient ischemic attack, cerebrovascular disorders and the like, or preventing progress of such disorders.

摘要翻译： PCT No.PCT / JP90 / 00970 Sec。 371日期：1993年1月22日 102（e）日期1993年1月22日PCT提交1990年7月30日PCT公布。 出版物WO92 / 02487 （I）的二胺化合物或其加成盐提供：（I）这些化合物具有优异的脑保护作用，非常安全，并且在口服给药时表现出强烈的作用， 因此，含有这些化合物的药物对于治疗由脑出血，脑梗塞，蛛网膜下腔出血，短暂性脑缺血发作，脑血管障碍等引起的疾病或预防这些障碍的进展是有效的。

公开(公告)号：US4960883A

公开(公告)日：1990-10-02

申请号：US310683

申请日：1989-02-15

申请人： Sohei Tanabe ,  Seiichi Sato ,  Yoshinori Kyotani ,  Tomio Ohta ,  Yasumi Uchida

发明人： Sohei Tanabe ,  Seiichi Sato ,  Yoshinori Kyotani ,  Tomio Ohta ,  Yasumi Uchida

IPC分类号： C07D295/18 ,  A61K31/47 ,  A61K31/472 ,  A61K31/495 ,  A61K31/55 ,  A61P9/00 ,  C07D217/02 ,  C07D243/08 ,  C07D295/192 ,  C07D295/22 ,  C07D295/26

CPC分类号： C07D295/192 ,  C07D217/02 ,  C07D295/26

摘要： A propane derivative represented by the following formula ##STR1## wherein R represents a lower alkyl group; one of A and B represents a group of the formula ##STR2## and the other represents a group of the formula ##STR3## in which R.sup.1 and R.sup.2 are identical or different and each represents a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, R.sup.3 represents a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group, and X represents a sulfonyl group or a carbonyl group,and an acid addition salt thereof. The compounds provided by this invention have useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular diseases such as angina pectoris, cerebral circulation disorder and thrombosis.

公开(公告)号：US4948892A

公开(公告)日：1990-08-14

申请号：US310684

申请日：1989-02-15

申请人： Sohei Tanabe ,  Seiichi Sato ,  Yoshinori Kyotani ,  Tomio Ohta ,  Yasumi Uchida

发明人： Sohei Tanabe ,  Seiichi Sato ,  Yoshinori Kyotani ,  Tomio Ohta ,  Yasumi Uchida

IPC分类号： C07D295/12 ,  A61K31/495 ,  A61P9/00 ,  C07D213/74 ,  C07D213/75 ,  C07D241/04 ,  C07D295/13

CPC分类号： C07D213/74 ,  C07D295/13

摘要： A sulfonamide compound represented by the following formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are identical or different, and each represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a hydrogen atom, a lower alkyl group, or a substituted or unsubstituted aralykyl group; R.sup.5 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group; R.sup.6 and R.sup.7 are identical or different and each represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; and n is an integer of 1 to 8,and an acid addition salt thereof. The compounds of formula (I) provided by this invention have some useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular disorders such as angina pectoris, cerebral circulation disorder and thrombosis.

公开(公告)号：US4886822A

公开(公告)日：1989-12-12

申请号：US179218

申请日：1988-04-08

申请人： Kimiyuki Shibuya ,  Yoshio Takahashi ,  Seiichi Sato ,  Hiromichi Shigyo ,  Tomio Ohta ,  Yasumi Uchida

发明人： Kimiyuki Shibuya ,  Yoshio Takahashi ,  Seiichi Sato ,  Hiromichi Shigyo ,  Tomio Ohta ,  Yasumi Uchida

IPC分类号： C07D233/61 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61P9/06 ,  C07D213/04 ,  C07D213/30 ,  C07D213/40 ,  C07D213/50 ,  C07D213/70 ,  C07D213/79 ,  C07D213/80 ,  C07D213/82 ,  C07D213/89 ,  C07D233/54 ,  C07D233/64 ,  C07D233/84 ,  C07D471/04 ,  C07D521/00

CPC分类号： C07D213/30 ,  C07D213/40 ,  C07D213/50 ,  C07D213/70 ,  C07D213/79 ,  C07D213/80 ,  C07D213/82 ,  C07D213/89 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D233/84 ,  C07D249/08 ,  C07D471/04

摘要： A substituted anilide derivative of the formula ##STR1## wherein R.sub.1 represents a mononuclear or binuclear heterocyclic group which contains 1 to 3 nitrogen atoms as ring members and may have a substituent.A represents a single bond, a carbonyl group, a sulfur atom, or a lower alkylene group which may be substituted by a hydroxyl group,R.sub.2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a trifluoromethyl group, a lower alkenyloxy group, or a C.sub.1 -C.sub.14 alkoxy group which may have a substituent,R.sub.3 and R.sub.4 are identical or different, and each represents a hydrogen atom, a lower alkyl group, a phenyl group, or a phenyl(lower alkyl) group which may have a substitutent, or taken together, may form a saturated nitrogen-containing heterocyclic group together with the nitrogen atom to which they are bonded, andB represents a single bond or a lower alkylene group which may have a substituent,or an acid addition salt thereof. The compound of formula (I) or a pharmaceutically acceptable acid addition salt thereof is useful for the manufacture of antiarrhythmically active medicaments.

公开(公告)号：US4746737A

公开(公告)日：1988-05-24

申请号：US886046

申请日：1986-07-16

申请人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Koichiro Watanabe ,  Tomio Ohta ,  Nobuo Yokoo ,  Masahiko Nagakura

发明人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Koichiro Watanabe ,  Tomio Ohta ,  Nobuo Yokoo ,  Masahiko Nagakura

IPC分类号： C07C279/18 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D243/08 ,  C07D295/185 ,  C07D265/30

CPC分类号： C07D207/27 ,  C07C279/18 ,  C07D207/16 ,  C07D243/08 ,  C07D295/185

摘要： Novel benzoyl esters of the following formula (I), and acid addition salts thereof, ##STR1## in which R.sub.1 and R.sub.2 are the same or different and represent a hydrogen atom or a lower alkoxy group, A represents a single bond, a linear or branched lower alkylene group, a lower alkenylene group, R.sub.3 and R.sub.4 are the same or different and represent a hydrogen atom or a lower alkyl group, or R.sub.3 and R.sub.4 join together to form a lower alkylene group, R.sub.5 represents a group of the formula, --X--(CO).sub.n --Y in which X represents a single bond, a linear or branched lower alkylene group or an alkenylene group, n is 0 or 1, Y represents a hydrogen atom, a cycloalkyl group, an aryl group, a hydroxyl group, a lower alkoxy group and the like are prepared by reacting para-nitrobenzoic acid or its derivative with a compound of the general formula (III) or its derivative ##STR2## to obtain a compound of the general formula (IV) ##STR3## followed by reducing the compound of the formula (IX) ##STR4## and subjecting the compound (IX) to guanidylation reaction, or by reaction para-guanidinobenzoic derivative with compound (III) or its derivative.The benzoyl esters have strong anti-trypsin activity, anti-thrombin activity and anticoagulant activity with low toxicity and are useful as a medicine for treatment of pancreatitis and disseminated intravascular coagulation (DIC).

摘要翻译： 下式（I）的新型苯甲酰基酯及其酸加成盐，其中R 1和R 2相同或不同，表示氢原子或低级烷氧基，A表示单键， 直链或支链低级亚烷基，低级亚烯基，R3和R4相同或不同，表示氢原子或低级烷基，或R3和R4连接在一起形成低级亚烷基，R5表示 其中X表示单键的-X-（CO）nY，直链或支链低级亚烷基或亚烯基，n为0或1，Y表示氢原子，环烷基，芳基， 通过使对硝基苯甲酸或其衍生物与通式（III）的化合物或其衍生物（IMAGE）（III）反应来制备羟基，低级烷氧基等，以获得通式（III）的化合物 （Ⅳ），然后还原式（Ⅸ）化合物（IX）和 使化合物（IX）进行胍基化反应，或通过反应对 - 胍基苯甲酸衍生物与化合物（III）或其衍生物反应。 苯甲酰酯具有很强的抗胰蛋白酶活性，抗凝血酶活性和抗凝血活性，毒性低，可用作治疗胰腺炎和弥散性血管内凝血（DIC）的药物。

公开(公告)号：US06855122B1

公开(公告)日：2005-02-15

申请号：US09913248

申请日：2000-02-09

申请人： Tomio Ohta ,  Tetsuya Miyatake ,  Yoshihiko Kinoshita

发明人： Tomio Ohta ,  Tetsuya Miyatake ,  Yoshihiko Kinoshita

IPC分类号： A61M1/36 ,  A61M37/00

CPC分类号： A61M1/3621

摘要： There is provided an apparatus which reduces a bleeding amount upon an operation.A bloodless treating apparatus used upon a surgical treatment of an objet comprises: (A) a fluid replacement supply unit which quantitatively supplies a fluid replacement into a blood vessel leading to the object (24); and (B) a fluid replacement withdrawing unit which quantitatively withdraws the fluid replacement having passed through the object (24) from a blood vessel coming from the object.

摘要翻译： 提供了一种在手术时减少出血量的装置。一种用于对象的手术治疗的无血治疗装置包括：（A）液体替换供应单元，其将定量地将流体置换供给到通向对象的血管 （24）; 以及（B）液体替换抽出单元，其从从所述物体的血管定量地取出已经通过所述物体（24）的液体置换装置。

公开(公告)号：US5576324A

公开(公告)日：1996-11-19

申请号：US325270

申请日：1994-10-27

申请人： Yoshinori Kyotani ,  Tadaaki Ohgiya ,  Tsutomu Toma ,  Yuji Kurihara ,  Takahiro Kitamura ,  Takashi Yamaguchi ,  Kazuhiro Onogi ,  Seiichi Sato ,  Hiromichi Shigyo ,  Tomio Ohta ,  Mitsuo Kawada ,  Yasumi Uchida

发明人： Yoshinori Kyotani ,  Tadaaki Ohgiya ,  Tsutomu Toma ,  Yuji Kurihara ,  Takahiro Kitamura ,  Takashi Yamaguchi ,  Kazuhiro Onogi ,  Seiichi Sato ,  Hiromichi Shigyo ,  Tomio Ohta ,  Mitsuo Kawada ,  Yasumi Uchida

IPC分类号： C07D491/04 ,  C07D491/048 ,  C07D491/056 ,  A61K31/44

CPC分类号： C07D491/04

摘要： A quinoline derivative represented by general formula (1), a medicinally acceptable salt thereof, and a remedy for cardiac diseases containing the same: ##STR1## [wherein ring A represents a furan, dihydrofuran or dioxolane ring, and R.sup.1 represents an aminoalkyl group].The compound (1) has a positively inotropic effect on myocardia and an antiarrhythmic effect, and can dilate blood vessels without extremely increasing the heart rate. Therefore, a remedy for cardiac diseases containing the same as the active ingredient is remarkably useful for treating cardiac insufficiency, arrhythmia, and so forth.

摘要翻译： PCT No.PCT / JP93 / 00566 Sec。 371日期：1994年10月27日 102（e）日期1994年10月27日PCT提交1993年4月28日PCT公布。 公开号WO93 / 22317 日本特公昭日1993年11月11日由通式（1）表示的喹啉衍生物及其药学上可接受的盐以及含有该喹啉衍生物的心脏病的药物：其中环A表示呋喃，二氢呋喃或二氧戊环 ，R1表示氨基烷基]。 化合物（1）对心肌具有正性变力作用，具有抗心律失常作用，能够扩张血管而不会极大地提高心率。 因此，含有与活性成分相同的心脏病的治疗对于治疗心功能不全，心律失常等是非常有用的。

公开(公告)号：US06336910B1

公开(公告)日：2002-01-08

申请号：US09187986

申请日：1998-11-09

申请人： Tomio Ohta ,  Takuichi Kobayashi

发明人： Tomio Ohta ,  Takuichi Kobayashi

IPC分类号： A61M3700

CPC分类号： A61M1/369 ,  A61F2007/126 ,  A61M2205/36 ,  A61M2205/3606 ,  Y10S128/03

摘要： An extracorporeal circulation apparatus capable of maintaining hypothermia for a prolonged period when used in the selective cooling method. The extracorporeal circulation apparatus used in the selective cooling method includes (1) a diluent supply unit for cooling a diluent and metering the diluent into a blood vessel; (2) a blood concentration unit for metering a diluted blood out from a blood vessel and concentrating the diluted blood thus drawn out by filtering the diluted blood; and (3) a blood supply unit for heating the concentrated blood and metering the concentrated blood into a blood vessel, wherein a flow rate of the injected diluent flow rate, Vd and a flow rate of a filtrate, Vb are so controlled that a relationship 0.1 Vd≦Vb≦Vd is maintained.

摘要翻译： 一种体外循环装置，其能够在选择性冷却方法中使用时能够长时间保持低温。选择冷却方法中使用的体外循环装置包括（1）稀释剂供给单元，其用于冷却稀释剂并将稀释剂计量到血管 ; （2）用于从血管计量稀释的血液的血液浓缩单元，并且通过过滤稀释的血液浓缩由此抽出的稀释血液; 和（3）用于加热浓缩血液并将浓缩血液计量到血管中的血液供应单元，其中注入的稀释剂流量Vd和滤液的流量Vb的流量被控制为使得关系 保持0.1 Vd <= Vb <= Vd。

公开(公告)号：US4567890A

公开(公告)日：1986-02-04

申请号：US638562

申请日：1984-08-07

申请人： Tomio Ohta ,  Noboru Funatsu

发明人： Tomio Ohta ,  Noboru Funatsu

IPC分类号： A61B18/12 ,  A61B17/30 ,  A61B18/14 ,  A61M3/02 ,  A61B17/36

CPC分类号： A61B18/1442 ,  A61B17/30 ,  A61B2217/007 ,  A61M3/0279

摘要： A pair of bipolar diathermy forceps used for surgery having two arms electrically insulated from each other and adapted to keep opening their tips usually, comprising a tube which extends toward the inside tips of the arms and which is mounted along a groove, the said groove is provided on either or both of the arms, an elongate section which follows the said groove, an operational section inserted between two arms whereby a hole of the tube is open, when the said arms are closed and is closed when they are open, and a pouring section of physiological saline which is connected to the end of the tube. Irrigation is started when the arms are closed and is stopped when they are open automatically. When the tissue is held by the tips of arms and supplied with the current, the coagulation is caused by the high frequency conducted, whereby the control of hemorrhage is completed. The frequent saline irrigation of the work area in microsurgery and the dilution of a little bleeding can be obtained.

摘要翻译： 一对用于手术的双极性透热镊子，其具有彼此电绝缘并且适于通常保持开口的手臂，包括朝向臂的内部尖端延伸并且沿着凹槽安装的管，所述凹槽是 设置在所述臂中的一个或两个上，与所述凹槽相邻的细长部分，插入在两个臂之间的操作部分，其中当所述臂闭合并且当所述臂打开时关闭时，所述管的孔打开，并且 生理盐水的浇注部分连接到管的端部。 当手臂关闭并在自动打开时停止灌溉。 当组织被手臂的尖端保持并且被提供电流时，由高频传导引起凝血，由此完成出血控制。 显微手术中工作区频繁的盐水灌洗和稀释少许出血。