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    Method for late introduction of the (8R) hydroxyl group carbapenem β-lactam antibiotic synthesis
    1.
    发明授权
    Method for late introduction of the (8R) hydroxyl group carbapenem β-lactam antibiotic synthesis 有权
    晚期引入（8R）羟基碳青霉烯β-内酰胺抗生素合成方法

    公开(公告)号：US09458479B2

    公开(公告)日：2016-10-04

    申请号：US14860103

    申请日：2015-09-21

    申请人： THE JOHNS HOPKINS UNIVERSITY

    发明人： Craig Arthur Townsend ,  Micah Jeffrey Bodner ,  Ryan Martin Phelan ,  Michael Francis Freeman

    IPC分类号： C07D477/20 ,  C12P17/10 ,  C12P17/18

    CPC分类号： C12P17/10 ,  C07D477/20 ,  C12P17/184

    摘要： The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydroxylates PS-5 giving N-acetyl thienamycin. ThnG catalyzes sequential desaturation and sulfoxidation of PS-5, giving PS-7 and its sulfoxide. The ThnG and ThnQ enzymes are relatively substrate selective, but give rise to the oxidative diversity of carbapenems produced by S. cattleya, and orthologues likely function similarly in allied streptomyces.

    摘要翻译： 目前公开的主题表明，由链霉菌链霉菌中的噻吩霉素基因簇编码的ThnG和ThnQ酶分别氧化碳青霉烯的C-2和C-6部分。 ThnQ立体选择性羟基化PS-5给予N-乙酰基噻吩霉素。 ThnG催化PS-5的顺序去饱和和亚磺氧化，得到PS-7及其亚砜。 ThnG和ThnQ酶是相对底物选择性的，但导致由S. cattleya产生的碳青霉烯类的氧化多样性，直系同源物在相关的链霉菌中可能具有相似的功能。

    Carbapenem compounds and their production
    5.
    发明授权
    Carbapenem compounds and their production 失效
    碳青霉烯化合物及其生产

    公开(公告)号：US4409147A

    公开(公告)日：1983-10-11

    申请号：US236310

    申请日：1981-02-20

    申请人： Mitsuko Asai ,  Susumu Shinagawa ,  Akira Imada

    发明人： Mitsuko Asai ,  Susumu Shinagawa ,  Akira Imada

    IPC分类号： C07D477/20 ,  C12P17/18 ,  C07D487/04

    CPC分类号： C07D477/20 ,  C12P17/184

    摘要： Novel carbapenem compounds, which are shown by the formula (I): ##STR1## wherein R is --SO.sub.3 H or hydrogen, or a physiologically acceptable salt thereof, are useful as a bactericide or disinfectant, and also produce a synergistic effect with penicillin and/or cephalosporin antibiotic agents.The compound of the formula (I) can be produced by subjecting to reduction reaction a compound of the formula: ##STR2## wherein R has the same meaning as defined above, or a salt thereof.

    摘要翻译： 由式（I）表示的新型碳青霉烯化合物：其中R为-SO 3 H或氢的化合物或其生理学上可接受的盐可用作杀菌剂或消毒剂，并且还可产生与 青霉素和/或头孢菌素抗生素。 式（I）化合物可以通过将下式化合物或其盐与下式化合物进行还原反应来制备：其中R具有与上述相同的含义。

    Process for producing antibiotic desacetyl 890A.sub.10
    9.
    发明授权
    Process for producing antibiotic desacetyl 890A.sub.10 失效
    生产抗生素脱乙酰基890A10的方法

    公开(公告)号：US4264734A

    公开(公告)日：1981-04-28

    申请号：US74289

    申请日：1979-09-11

    申请人： Jean S. Kahan ,  Frederick M. Kahan

    发明人： Jean S. Kahan ,  Frederick M. Kahan

    IPC分类号： C07D477/20 ,  C12P17/18

    CPC分类号： C07D477/20 ,  C12P17/184 ,  Y10S435/822

    摘要： This invention relates to the new antibiotic, desacetyl 890A.sub.10, active against both gram-positive and gram-negative bacteria, which is produced by treating 890A.sub.10 with an N-acetyl-890A.sub.10 amidohydrolase produced by a soil microorganism isolated by enrichment techniques. This invention also relates to the process by which 890A.sub.10 is enzymatically deacetylated.

    摘要翻译： 本发明涉及通过用通过富集技术分离的土壤微生物产生的N-乙酰基-890A10酰胺水解酶处理890A10而产生的革兰氏阳性和革兰氏阴性细菌的新型抗生素脱乙酰基890A10。 本发明还涉及890A10被酶脱乙酰化的方法。