公开(公告)号：US12099046B2

公开(公告)日：2024-09-24

申请号：US17436770

申请日：2019-10-03

Applicant: Solventum Intellectual Properties Company

Inventor： Brian E. Brooks ,  Gilles J. Benoit ,  Peter O. Olson ,  Tyler W. Olson ,  Himanshu Nayar ,  Frederick J. Arsenault ,  Nicholas A. Johnson ,  Susan L Woulfe ,  Mark A. Tomai

IPC: G05B13/04 ,  B01J19/00 ,  G01N33/15

CPC classification number: G01N33/15 ,  B01J19/0013 ,  B01J19/0033 ,  G05B13/041

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for optimizing a process of manufacturing a biologic pharmaceutical. In one aspect, the method comprises repeatedly performing the following: i) selecting a configuration of input settings for manufacturing a batch of a biologic pharmaceutical based on a causal model that measures current causal relationships between input settings and a measure of a quality of batches of the biological pharmaceutical; ii) determining a measure of the quality of a batch of the biological pharmaceutical manufactured using the configuration of input settings; and iii) adjusting, based on the measure of the quality of the batch of the biological pharmaceutical, the causal model.