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公开(公告)号：US20200375516A1
公开(公告)日：2020-12-03
申请号：US16999213
申请日：2020-08-21
Applicant: SteadyMed Ltd.
Inventor： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
Abstract: A displacement-generating battery cell for driving a drug-delivery device is described. The cell may include at least one volume-changing element. The cell may include a housing formed according to a concertina-shaped design with folds in the walls thereof and may contain an internal chemical reaction system. The chemical reaction system may include an electrode. The electrode may be the volume-changing element. The arrangement of said chemical reaction system may be such that an expansion of the volume-changing element in a direction lengthens the cell and thus reduces the extent of the folds. Drug-delivery devices including the displacement-generating battery cell are also described.
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公开(公告)号：US11013855B2
公开(公告)日：2021-05-25
申请号：US16377992
申请日：2019-04-08
Applicant: SteadyMed Ltd.
Inventor： Nir Rotem
Abstract: Embodiments may include a method of delivering a drug. The method may include removing or releasing a structure from a patch-pump assembly. The patch-pump assembly may include a sealed prefilled drug-reservoir, a fluid passageway, a cannula-containing assembly, and a penetrator. The method may also include penetrating the sealed prefilled drug-reservoir containing the drug to establish fluid communication between the sealed prefilled drug-reservoir and a fluid passageway by removing or releasing the structure. The method may further include flowing the drug from the prefilled drug-reservoir to the fluid passageway. In addition, the method may include flowing the drug from the fluid passageway to a cannula-containing assembly. Furthermore, the method may include delivering the drug subcutaneously to a subject using the cannula-containing assembly.
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公开(公告)号：US20190060563A1
公开(公告)日：2019-02-28
申请号：US16173069
申请日：2018-10-29
Applicant: SteadyMed, Ltd.
Inventor： Nir Rotem , Keren Fradkin , Jonathan Goldstein
Abstract: A drug-delivery device comprising a drug-reservoir assembly, displacement-generating actuator, and drug administration unit is described, wherein the drug-reservoir assembly comprises at least one flexible wall and a constraining ring, such that the displacement generated by the actuator collapses a flexible wall of the assembly expelling the drug contents of the drug-reservoir towards said drug administration means.
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公开(公告)号：US20170304532A1
公开(公告)日：2017-10-26
申请号：US15605420
申请日：2017-05-25
Applicant: SteadyMed Ltd.
Inventor： Nir Rotem
CPC classification number: A61M5/14248 , A61M5/145 , A61M5/158 , A61M5/1626 , A61M2005/14252 , A61M2005/1585 , F04C2270/041
Abstract: Embodiments may include a method of delivering a drug. The method may include removing or releasing a structure from a patch-pump assembly. The patch-pump assembly may include a sealed prefilled drug-reservoir, a fluid passageway, a cannula-containing assembly, and a penetrator. The method may also include penetrating the sealed prefilled drug-reservoir containing the drug to establish fluid communication between the sealed prefilled drug-reservoir and a fluid passageway by removing or releasing the structure. The method may further include flowing the drug from the prefilled drug-reservoir to the fluid passageway. In addition, the method may include flowing the drug from the fluid passageway to a cannula-containing assembly. Furthermore, the method may include delivering the drug subcutaneously to a subject using the cannula-containing assembly.
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公开(公告)号：US10335542B2
公开(公告)日：2019-07-02
申请号：US15605420
申请日：2017-05-25
Applicant: SteadyMed Ltd.
Inventor： Nir Rotem
Abstract: Embodiments may include a method of delivering a drug. The method may include removing or releasing a structure from a patch-pump assembly. The patch-pump assembly may include a sealed prefilled drug-reservoir, a fluid passageway, a cannula-containing assembly, and a penetrator. The method may also include penetrating the sealed prefilled drug-reservoir containing the drug to establish fluid communication between the sealed prefilled drug-reservoir and a fluid passageway by removing or releasing the structure. The method may further include flowing the drug from the prefilled drug-reservoir to the fluid passageway. In addition, the method may include flowing the drug from the fluid passageway to a cannula-containing assembly. Furthermore, the method may include delivering the drug subcutaneously to a subject using the cannula-containing assembly.
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Patent Agency Ranking
公开(公告)号：US20180035935A1
公开(公告)日：2018-02-08
申请号：US15634880
申请日：2017-06-27
Applicant: SteadyMed Ltd.
Inventor： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
Abstract: Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.
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公开(公告)号：US09724462B2
公开(公告)日：2017-08-08
申请号：US14384152
申请日：2013-03-14
Applicant: SteadyMed Ltd.
Inventor： Nir Rotem
CPC classification number: A61M5/14248 , A61M5/145 , A61M5/158 , A61M5/1626 , A61M2005/14252 , A61M2005/1585 , F04C2270/041
Abstract: The present invention provides a selectively activatable patch-pump assembly, said patch-pump assembly comprising: • a sealed prefilled drug-reservoir containing a drug to be delivered; • an associated conduit in connection therewith; • a selectively activatable penetrator which penetrates said sealed prefilled drug-reservoir and facilitates drug access to said conduit; and • a selectively activatable, associated, cannula-containing assembly for delivering a drug subcutaneously to a subject, in fluid connection with said conduit; wherein a selective activation-step initiates penetration of said sealed prefilled drug-reservoir, drug access from said drug-reservoir to said conduit, drug access from said conduit to said cannula-containing assembly and delivery from said cannula-containing assembly, thereby being a selectively activatable patch-pump assembly.
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公开(公告)号：US10750987B2
公开(公告)日：2020-08-25
申请号：US15634880
申请日：2017-06-27
Applicant: SteadyMed Ltd.
Inventor： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
Abstract: Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.
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公开(公告)号：US09687186B2
公开(公告)日：2017-06-27
申请号：US13956965
申请日：2013-08-01
Applicant: SteadyMed Ltd.
Inventor： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
CPC classification number: A61B5/157 , A61B5/15003 , A61B5/150992 , A61M5/1452 , A61M5/14526 , A61M2005/14204
Abstract: Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.
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公开(公告)号：US20150038907A1
公开(公告)日：2015-02-05
申请号：US14384152
申请日：2013-03-14
Applicant: SteadyMed Ltd.
Inventor： Nir Rotem
CPC classification number: A61M5/14248 , A61M5/145 , A61M5/158 , A61M5/1626 , A61M2005/14252 , A61M2005/1585 , F04C2270/041
Abstract: The present invention provides a selectively activatable patch-pump assembly, said patch-pump assembly comprising: •a sealed prefilled drug-reservoir containing a drug to be delivered; •an associated conduit in connection therewith; •a selectively activatable penetrator which penetrates said sealed prefilled drug-reservoir and facilitates drug access to said conduit; and •a selectively activatable, associated, cannula-containing assembly for delivering a drug subcutaneously to a subject, in fluid connection with said conduit; wherein a selective activation-step initiates penetration of said sealed prefilled drug-reservoir, drug access from said drug-reservoir to said conduit, drug access from said conduit to said cannula-containing assembly and delivery from said cannula-containing assembly, thereby being a selectively activatable patch-pump assembly.
Abstract translation: 本发明提供了一种可选择性激活的贴片泵组件，所述贴片泵组件包括：•密封预填充药物储存器，其含有待递送的药物; •与之相关的导管; •可选择性激活的穿透器，其穿透所述密封预填充药物储存器并且便于药物进入所述导管; 以及•可选择性激活的，相关联的含插管的组件，用于将药物皮下地递送到与所述导管流体连接的受试者; 其中选择性活化步骤启动所述密封预填充药物储存器的穿透，从所述药物储存器到所述导管的药物进入，从所述导管到所述套管的组件的药物进入以及从所述含套管的组件的输送，从而成为 可选择性激活的贴片泵组件。
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