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公开(公告)号：US4405305A
公开(公告)日：1983-09-20
申请号：US235185
申请日：1981-02-17
CPC分类号： A61M39/0208
摘要： A novel implantable, peritoneal injection catheter apparatus and method, the apparatus including an open top, fluid-receiving reservoir mounted to one end of a hollow stem and a penetrable membrane covering the open top of the receiving reservoir. The hollow stem is configurated to extend into the peritoneal cavity and includes a retaining flange system for retaining the hollow stem in fluid communication with the peritoneal cavity. The penetrable membrane serves as an injection site for inserting a hollow needle into the receiving reservoir. The penetrable membrane also includes a dome configuration that may be depressed to expel injection fluids from the reservoir into the peritoneal cavity. A substantial portion of the injection catheter is covered with a velour coating to accomodate tissue ingrowth for further securement of the catheter in the tissue of the abdominal wall.
摘要翻译： 一种新颖的可植入式腹膜注射导管装置和方法，该装置包括安装在中空杆的一端的开放式顶部流体接收容器和覆盖接收容器的敞开顶部的可穿透膜。 空心杆构造成延伸到腹膜腔中，并且包括用于保持中空杆与腹膜腔流体连通的保持凸缘系统。 可穿透膜用作将中空针插入接收容器的注射部位。 可渗透膜还包括可以被压下以将注射流体从储存器排出到腹膜腔中的圆顶构型。 注射导管的大部分用丝绒涂层覆盖以容纳组织向内生长，以进一步将导管固定在腹壁的组织中。
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公开(公告)号：US5141493A
公开(公告)日：1992-08-25
申请号：US470978
申请日：1990-01-26
CPC分类号： A61M1/28 , A61M1/281 , A61M1/1696 , A61M2205/3393
摘要： A peritoneal dialysis system is disclosed for administering substantially sterile dialysate to the peritoneal cavity of a patient. The system includes a dialyzer for passing a primary solution and a secondary solution therethrough to enabale removal of waste products from the primary solution to the secondary solution, and a primary circuit for selectively circulating a primary solution through the dialyzer. Connecting conduits or tubing is provided for selectively carrying primary solution from the primary circuit to the peritoneal cavity of the patient and for selectively withdrawing at least some of the solution from the peritoneal cavity back into the primary circuit. A pump is disposed in the primary circuit for causing primary solution to circulate in the primary circuit independently of transfer of primary solution between the primary circuit and the peritoneal cavity of the patient. A secondary circuit is coupled to the dialyzer for supplying a secondary solution thereto and for carrying secondary solution from the dialyzer. A supply source of primary solution is coupled to the primary circuit to initially charge the circuit, and a supply source of secondary solution is coupled to the secondary circuit to continually supply secondary solution thereto.
摘要翻译： 公开了一种腹膜透析系统，用于向患者的腹膜腔施用基本无菌的透析液。 该系统包括透析器，用于使一次溶液和二次溶液通过其中，从而将废物从主溶液移除到二次溶液，以及用于选择性地使初级溶液循环通过透析器的初级回路。 提供连接管道或管道以选择性地将一次溶液从初级回路输送到患者的腹膜腔，并且用于选择性地将至少一些溶液从腹腔抽回到主回路中。 一个泵设置在主回路中，用于使主要溶液在初级回路中循环，而与初级回路和患者腹膜腔之间的主要溶液的转移无关。 辅助电路耦合到透析器，用于向其提供二次溶液并用于从透析器输送二次溶液。 主要解决方案的供应源耦合到初级电路以对电路进行初始充电，并且次级解决方案的供应源耦合到次级电路以连续地向其提供二级解决方案。
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3.发明授权
公开(公告)号：US4559033A
公开(公告)日：1985-12-17
申请号：US522907
申请日：1983-08-12
CPC分类号： A61M39/0208
摘要： The present invention is directed to subcutaneous peritoneal injection catheters and methods which minimize catheter obstruction during use. The apparatus includes a receiving chamber or reservoir having a relatively small internal volume while employing a penetrable membrane and relatively enlarged target surface area. The reservoir is interconnected with the peritoneal cavity by a hollow stem. The penetrable membrane accommodates a hollow needle being inserted into the receiving reservoir and is configurated with a dome-like profile so that the membrane may also be depressed to expel insulin from the receiving reservoir into the peritoneal cavity in a direction generally toward the mesenteric peritoneal membrane.The distal end of the hollow stem (which is situated inside the peritoneal cavity), is constructed so as to minimize the likelihood of catheter obstruction during use by a patient. For example, in one presently preferred embodiment of the invention, the distal end of the stem is provided with two, parallel, diametrally enlarged flanges. The two flanges are unequal in size, and they are positioned on the stem such that the larger flange resides against the peritoneal membrane and the smaller flange is located immediately adjacent the distal opening of the stem. In addition, an antibacterial agent may be placed within the device, and the device may also be formed of or coated with a substance which inhibits body cell and bacterial growth.
摘要翻译： 本发明涉及皮下腹膜内注射导管和使用过程中导管阻塞最小化的方法。 该装置包括具有相对小的内部体积的接收室或容器，同时使用可穿透的膜和相对扩大的目标表面积。 储存器通过中空茎与腹膜腔相互连接。 可穿透的膜容纳插入接收容器中的中空针，并且被配置成具有圆顶状轮廓，使得膜也可以被压下，以将胰岛素从接收储器排出到通常朝向肠系膜腹膜的方向进入腹膜腔 。 中空杆（位于腹腔内）的远端被构造成使患者使用期间导管阻塞的可能性最小化。 例如，在本发明的一个目前优选的实施例中，杆的远端设置有两个平行的径向扩大的凸缘。 两个凸缘的尺寸不相等，并且它们位于杆上，使得较大的凸缘抵靠腹膜，并且较小的凸缘位于杆的远端开口附近。 此外，抗菌剂可以放置在装置内，并且该装置也可以由抑制体细胞和细菌生长的物质形成或涂覆。
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公开(公告)号：US5196002A
公开(公告)日：1993-03-23
申请号：US716926
申请日：1991-06-18
申请人： Barry K. Hanover , Stephen C. Jacobsen , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
发明人： Barry K. Hanover , Stephen C. Jacobsen , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
CPC分类号： A61K9/0024 , A61M31/002
摘要： An implantable drug delivery system includes a housing having a base end and a discharge end, for holding drug solution at the discharge end, a valve disposed at the discharge end to allow a drug solution to flow from inside the housing, through the valve and out of the housing when solution pressure is applied to the valve, a piston slidably disposed in the housing to slide between the base end and discharge end to force solution toward the discharge end and out the valve, and a spring disposed in the housing between the piston and the base end thereof for urging the piston toward the discharge end. A plurality of different length tethers are connected at one end to the piston and at the other end to a respective release node located at the base end of the housing. Each release node holds the other end of a respective one of the tethers until a release signal is received at which time it releases the tether. A timing circuit is disposed in the housing at the base end to supply release signals sequentially to the nodes in order of the shortest tether node to the longest tether node so that as a tether is released, the piston is allowed to move toward the discharge end of the housing to thereby discharge or bolus of drug solution from the housing, until the next shortest unreleased tether stops further movement of the piston.
摘要翻译： 可植入药物输送系统包括具有基端和排出端的壳体，用于在排出端保持药物溶液，设置在排出端处的阀，以允许药物溶液从壳体内部流过阀门并出口 的壳体，其中所述壳体被施加到所述阀上;活塞，其可滑动地设置在所述壳体中以在所述基端和排出端之间滑动，以迫使溶液朝向排出端并排出所述阀;以及弹簧，设置在所述壳体中的所述活塞 和其基端用于将活塞推向排出端。 多个不同长度的系绳在一端连接到活塞，另一端连接到位于壳体基端的相应的释放节点。 每个释放节点保持系链中相应一个的另一端，直到接收释放信号，此时它释放系绳。 定时电路设置在基座的外壳中，以便按照最短系链节点到最长系绳节点的顺序向节点顺序地提供释放信号，以便当释放系绳时，允许活塞向排放端移动 从而将药物溶液从壳体排出或推出，直到下一个最短的未释放的系链停止活塞的进一步移动。
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公开(公告)号：US4477971A
公开(公告)日：1984-10-23
申请号：US536304
申请日：1983-09-27
CPC分类号： A61N1/044 , A61N1/0472 , Y10T29/4921
摘要： An iontophoretic bioelectrode includes an enclosure having a bottom wall formed of a membrane through which ions may migrate when subjected to an electric field, and an upper wall joined to the bottom wall to define an interior compartment for holding an ion-containing solution. An electrode in the form of the male portion of a conventional clothing snap is mounted to the enclosure to communicate electrically with solution contained in the interior compartment. A needle receiving element is mounted in the upper wall of the enclosure. This element is in the form of a section of conduit having a receiving end, which is directed upwardly, and a blocking end which includes a platform for preventing a needle inserted into the receiving end from passing all the way through the conduit. A resilient plug is disposed in the receiving end of the conduit to prevent solution from escaping from the interior compartment. The plug is formed of a material through which a needle may be inserted but which, when the needle is retracted, closes about the opening made by the needle to prevent the escape of solution.
摘要翻译： 离子电渗生物电极包括具有由膜形成的底壁的外壳，当经受电场时，离子可以通过该膜离子迁移，以及连接到底壁以限定用于保持含离子溶液的内部隔间的上壁。 传统衣服弹簧的阳部形式的电极安装到外壳上，以与包含在内部隔室中的溶液电气通信。 针接收元件安装在外壳的上壁中。 该元件是导管部分的形式，其具有向上指向的接收端，以及阻塞端，其包括用于防止插入接收端的针穿过导管的平台。 弹性塞子设置在导管的接收端中，以防止溶液从内部隔间逸出。 塞子由可以插入针的材料形成，但是当针缩回时，围绕由针形成的开口封闭以防止溶液逸出。
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公开(公告)号：US5059175A
公开(公告)日：1991-10-22
申请号：US594271
申请日：1990-10-09
申请人： Barry K. Hanover , Stephen C. Jacobsen , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
发明人： Barry K. Hanover , Stephen C. Jacobsen , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
CPC分类号： A61K9/0024 , A61M31/002
摘要： An implantable drug delivery system includes a housing having a base end and a discharge end, for holding drug solution at the discharge end, a valve disposed at the discharge end to allow a drug solution to flow from inside the housing, through the valve and out of the housing when solution pressure is applied to the valve, a piston slidably disposed in the housing to slide between the base end and discharge end to force solution toward the discharge end and out the valve, and a spring disposed in the housing between the piston and the base end thereof for urging the piston toward the discharge end. A plurality of different length tethers are connected at one end to the piston and at the other end to a respective release node located at the base end of the housing. Each release node holds the other end of a respective one of the tethers until a release signal is received at which time it releases the tether. A timing circuit is disposed in the housing at the base end to supply release signals sequentially to the nodes in order of the shortest tether node to the longest tether node so that as a tether is released, the piston is allowed to move toward the discharge end of the housing to thereby discharge or bolus of drug solution from the housing, until the next shortest unreleased tether stops further movement of the piston.
摘要翻译： 可植入药物输送系统包括具有基端和排出端的壳体，用于在排出端保持药物溶液，设置在排出端处的阀，以允许药物溶液从壳体内部流过阀门并出口 的壳体，其中所述壳体被施加到所述阀上;活塞，其可滑动地设置在所述壳体中以在所述基端和排出端之间滑动，以迫使溶液朝向排出端并排出所述阀;以及弹簧，设置在所述壳体中的所述活塞 和其基端用于将活塞推向排出端。 多个不同长度的系绳在一端连接到活塞，另一端连接到位于壳体基端的相应的释放节点。 每个释放节点保持系链中相应一个的另一端，直到接收释放信号，此时它释放系绳。 定时电路设置在基座的外壳中，以便按照最短系链节点到最长系绳节点的顺序向节点顺序地提供释放信号，以便当释放系绳时，允许活塞向排放端移动 从而将药物溶液从壳体排出或推出，直到下一个最短的未释放的系链停止活塞的进一步移动。
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公开(公告)号：US5167625A
公开(公告)日：1992-12-01
申请号：US595087
申请日：1990-10-09
申请人： Stephen C. Jacobsen , Barry K. Hanover , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
发明人： Stephen C. Jacobsen , Barry K. Hanover , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
CPC分类号： A61M31/002
摘要： An implantable drug delivery system includes a housing having a plurality of compartments each of which includes an opening on one side thereof and a floor generally opposite the opening. Also included are a plurality of flexible drug containment sacks, each having a mouth circumscribing an opening in the sack, with the sack being disposed in a respective compartment with the mouth affixed to the opening of that compartment to seal the inside of the sack from the inside of the compartment and to enable holding a drug formulation in the sack. A plurality of covers are disposed over a respective compartment opening for preventing the release of drug formulation contained in the sacks in the compartment covered, until ruptured or removed. A plurality of gas generating elements are disposed at the floor of a respective compartment under the sack in that compartment and are responsive to initiation signals for producing gas to force the sacks and drug formulations against the covers to thereby rupture or remove the covers and force the formulations out of the housing. An electrical circuit supplies initiation signals to the gas generating means to initiate production of the gas and thus discharge of the drug formulation.
摘要翻译： 可植入药物输送系统包括具有多个隔室的壳体，每个隔室在其一侧包括一个开口和与开口大致相对的底板。 还包括多个柔性药物容纳袋，每个袋具有围绕袋中的开口的口，其中袋被设置在相应的隔室中，口中固定有该隔室的开口以将袋的内部从 在隔间内部，并且能够在药袋中保持药物制剂。 多个盖设置在相应的隔室开口上，用于防止包装在被覆盖的隔室中的袋中的药物制剂的释放，直到破裂或移除。 多个气体发生元件设置在该隔间中的袋下面的相应隔室的底板处，并响应于产生气体的起始信号，以迫使袋和药物制剂抵靠盖，从而破裂或移除盖并迫使 制剂出了房屋。 电路将起始信号提供给气体发生装置以启动气体的产生，从而释放药物制剂。
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公开(公告)号：US4484599A
公开(公告)日：1984-11-27
申请号：US535356
申请日：1983-09-23
CPC分类号： F16K7/065 , Y10T137/87064 , Y10T137/87161 , Y10T137/87716 , Y10T137/87772
摘要： A pinch-type shut-off, pressure- or flow-regulating valve having a flexible tube extending through a valve body wherein the flexible tube is pinched off by the action of an eccentric cam attached to a motor. As the eccentric cam is rotated the flexible tube can be pinched off as it presses against the opposing wall inside the valve body. A number of positions of pinching off can be achieved and a microswitch can be available to locate the position of the eccentric cam.
摘要翻译： 夹紧式切断，压力或流量调节阀，其具有延伸穿过阀体的柔性管，其中柔性管被附接到马达的偏心凸轮的作用夹紧。 当偏心凸轮旋转时，柔性管可以压靠在阀体内的相对壁上。 可以实现多个夹紧位置，并且可以使用微动开关来定位偏心凸轮的位置。
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公开(公告)号：US4419092A
公开(公告)日：1983-12-06
申请号：US319074
申请日：1981-11-06
CPC分类号： A61N1/044
摘要： An iontophoretic bioelectrode includes an enclosure having a bottom wall formed of a membrane through which ions may migrate when subjected to an electric field, and an upper wall joined to the bottom wall to define an interior compartment for holding an ion-containing solution. An electrode in the form of the male portion of a conventional clothing snap is mounted to the enclosure to communicate electrically with solution contained in the interior compartment. A needle receiving element is mounted in the upper wall of the enclosure. This element is in the form of a section of conduit having a receiving end, which is directed upwardly, and a blocking end which includes a platform for preventing a needle inserted into the receiving end from passing all the way through the conduit. A resilient plug is disposed in the receiving end of the conduit to prevent solution from escaping from the interior compartment. The plug is formed of a material through which a needle may be inserted but which, when the needle is retracted, closes about the opening made by the needle to prevent the escape of solution.
摘要翻译： 离子电渗生物电极包括具有由膜形成的底壁的外壳，当经受电场时，离子可以通过该膜离子迁移，以及连接到底壁以限定用于保持含离子溶液的内部隔间的上壁。 传统衣服弹簧的阳部形式的电极安装到外壳上，以与包含在内部隔室中的溶液电气通信。 针接收元件安装在外壳的上壁中。 该元件是导管部分的形式，其具有向上指向的接收端，以及阻塞端，其包括用于防止插入接收端的针穿过导管的平台。 弹性塞子设置在导管的接收端中，以防止溶液从内部隔间逸出。 塞子由可以插入针的材料形成，但是当针缩回时，围绕由针形成的开口封闭以防止溶液逸出。
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10.发明授权Apparatus and methods for minimizing cellular adhesion on peritoneal injection catheters 失效用于最小化腹膜注射导管上的细胞粘附的装置和方法
公开(公告)号：US4557724A
公开(公告)日：1985-12-10
申请号：US522914
申请日：1983-08-12
申请人： Donald E. Gregonis , Robert L. Stephen , Dennis L. Coleman , Stephen K. Hunter , Barry K. Hanover , Jeffrey J. Harrow
发明人： Donald E. Gregonis , Robert L. Stephen , Dennis L. Coleman , Stephen K. Hunter , Barry K. Hanover , Jeffrey J. Harrow
CPC分类号： A61M39/0208
摘要： The present invention is directed to a subcutaneous peritoneal injection catheter apparatus and methods which minimizes catheter obstruction during use. The apparatus includes a receiving chamber or reservoir having a relatively small internal volume while employing a penetrable membrane and relatively enlarged target surface area. The reservoir is interconnected with the peritoneal cavity by a hollow stem. The penetrable membrane accommodates a hollow needle being inserted into the receiving reservoir and is configurated with a dome-like profile so that the membrane may also be depressed to expel insulin from the receiving reservoir into the peritoneal cavity in a direction generally toward the mesenteric peritoneal membrane.The portion of the apparatus which is in the peritoneal cavity is preferably constructed of, or coated with, a material which is capable of minimizing the adhesion of cells and the growth of bacteria on that portion of the apparatus. In a presently preferred embodiment of the subcutaneous peritoneal injection catheter, the portion of the catheter to be within the peritoneal cavity is constructed of a polyurethane material, and this polyurethane material is then coated with a solution of polyurethane and poly(ethylene glycol) in a suitable solvent.
摘要翻译： 本发明涉及皮下腹膜内注射导管装置和使用过程中导尿管阻塞最小化的方法。 该装置包括具有相对小的内部体积的接收室或容器，同时使用可穿透的膜和相对扩大的目标表面积。 储存器通过中空茎与腹膜腔相互连接。 可穿透的膜容纳插入接收容器中的中空针，并且被配置成具有圆顶状轮廓，使得膜也可以被压下，以将胰岛素从接收储器排出到通常朝向肠系膜腹膜的方向进入腹膜腔 。 位于腹膜腔中的装置的部分优选由能够最小化细胞粘附和细菌生长在该装置的该部分上的材料构成或涂覆。 在皮下腹膜注射导管的当前优选实施例中，导管内部位于腹膜腔内的部分由聚氨酯材料构成，然后将该聚氨酯材料用聚氨酯和聚（乙二醇）溶液涂覆在 合适的溶剂。
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