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1.发明授权
公开(公告)号：US5160723A
公开(公告)日：1992-11-03
申请号：US671132
申请日：1991-03-18
申请人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
发明人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
CPC分类号： A61K51/1063 , C07K16/3046 , A61K2039/505 , A61K2121/00 , C07K2317/24 , C07K2317/55 , Y10S436/808 , Y10S436/813 , Y10S530/808 , Y10S530/809 , Y10S530/866
摘要： This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the coloretal carcinoma lesion and which is labeled with an imaging agent under conditions so as to form a complex between the monoclonal antibody and the cell surface antigen, imaging any complex so formed, and thereby imaging the colorectal carcinoma lesion.This invention also provides a monoclonal antibody designated AS 33 (ATCC Accession No. HB 8779) and the hybridoma which produces it.
摘要翻译： 本发明提供了一种在人类患者中对结肠直肠癌病变进行成像的方法，其包括向患者施用能够结合与该结肠癌病变相关的细胞表面抗原的单克隆抗体，并在成像剂的条件下进行标记， 在单克隆抗体和细胞表面抗原之间形成复合物，对如此形成的任何复合物进行成像，从而对结肠直肠癌病变进行成像。 本发明还提供了称为AS33（ATCC登录号HB 8779）和产生它的杂交瘤的单克隆抗体。
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2.发明授权
公开(公告)号：US5643550A
公开(公告)日：1997-07-01
申请号：US312633
申请日：1994-09-27
申请人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
发明人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
CPC分类号： A61K51/1063 , C07K16/3046 , A61K2039/505 , A61K2121/00 , C07K2317/24 , C07K2317/55 , Y10S436/808 , Y10S436/813 , Y10S530/808 , Y10S530/809 , Y10S530/837
摘要： This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the colorectal carcinoma lesion and which is labeled with an imaging agent under conditions so as to form a complex between the monoclonal antibody and the cell surface antigen, imaging any complex so formed, and thereby imaging the colorectal carcinoma lesion.This invention also provides a monoclonal antibody designated AS 33 (ATCC Accession No. HB 8779) and the hybridoma which produces it.
摘要翻译： 本发明提供了一种对人类患者的结肠直肠癌病变进行成像的方法，其包括向患者施用能够结合与结肠直肠癌病变相关的细胞表面抗原的单克隆抗体，并在成像剂的条件下进行标记， 在单克隆抗体和细胞表面抗原之间形成复合物，对如此形成的任何复合物进行成像，从而对结肠直肠癌病变进行成像。 本发明还提供了称为AS33（ATCC登录号HB 8779）和产生它的杂交瘤的单克隆抗体。
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3.发明授权
公开(公告)号：US5431897A
公开(公告)日：1995-07-11
申请号：US20223
申请日：1993-02-16
申请人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
发明人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
CPC分类号： A61K51/1063 , C07K16/3046 , A61K2039/505 , A61K2121/00 , C07K2317/24 , C07K2317/55 , Y10S436/808 , Y10S436/813 , Y10S530/808 , Y10S530/809 , Y10S530/837
摘要： This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the colorectal carcinoma lesion and which is labeled with an imaging agent under conditions so as to form a complex between the monoclonal antibody and the cell surface antigen, imaging any complex so formed, and thereby imaging the colorectal carcinoma lesion.This invention also provides a monoclonal antibody designated AS 33 (ATCC Accession No. HB 8779) and the hybridoma which produces it.
摘要翻译： 本发明提供了一种对人类患者的结肠直肠癌病变进行成像的方法，其包括向患者施用能够结合与结肠直肠癌病变相关的细胞表面抗原的单克隆抗体，并在成像剂的条件下进行标记， 在单克隆抗体和细胞表面抗原之间形成复合物，对如此形成的任何复合物进行成像，从而对结肠直肠癌病变进行成像。 本发明还提供了称为AS33（ATCC登录号HB 8779）和产生它的杂交瘤的单克隆抗体。
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