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1.发明授权
公开(公告)号：US5160723A
公开(公告)日：1992-11-03
申请号：US671132
申请日：1991-03-18
申请人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
发明人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
CPC分类号： A61K51/1063 , C07K16/3046 , A61K2039/505 , A61K2121/00 , C07K2317/24 , C07K2317/55 , Y10S436/808 , Y10S436/813 , Y10S530/808 , Y10S530/809 , Y10S530/866
摘要： This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the coloretal carcinoma lesion and which is labeled with an imaging agent under conditions so as to form a complex between the monoclonal antibody and the cell surface antigen, imaging any complex so formed, and thereby imaging the colorectal carcinoma lesion.This invention also provides a monoclonal antibody designated AS 33 (ATCC Accession No. HB 8779) and the hybridoma which produces it.
摘要翻译： 本发明提供了一种在人类患者中对结肠直肠癌病变进行成像的方法，其包括向患者施用能够结合与该结肠癌病变相关的细胞表面抗原的单克隆抗体，并在成像剂的条件下进行标记， 在单克隆抗体和细胞表面抗原之间形成复合物，对如此形成的任何复合物进行成像，从而对结肠直肠癌病变进行成像。 本发明还提供了称为AS33（ATCC登录号HB 8779）和产生它的杂交瘤的单克隆抗体。
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2.发明授权
公开(公告)号：US5643550A
公开(公告)日：1997-07-01
申请号：US312633
申请日：1994-09-27
申请人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
发明人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
CPC分类号： A61K51/1063 , C07K16/3046 , A61K2039/505 , A61K2121/00 , C07K2317/24 , C07K2317/55 , Y10S436/808 , Y10S436/813 , Y10S530/808 , Y10S530/809 , Y10S530/837
摘要： This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the colorectal carcinoma lesion and which is labeled with an imaging agent under conditions so as to form a complex between the monoclonal antibody and the cell surface antigen, imaging any complex so formed, and thereby imaging the colorectal carcinoma lesion.This invention also provides a monoclonal antibody designated AS 33 (ATCC Accession No. HB 8779) and the hybridoma which produces it.
摘要翻译： 本发明提供了一种对人类患者的结肠直肠癌病变进行成像的方法，其包括向患者施用能够结合与结肠直肠癌病变相关的细胞表面抗原的单克隆抗体，并在成像剂的条件下进行标记， 在单克隆抗体和细胞表面抗原之间形成复合物，对如此形成的任何复合物进行成像，从而对结肠直肠癌病变进行成像。 本发明还提供了称为AS33（ATCC登录号HB 8779）和产生它的杂交瘤的单克隆抗体。
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3.发明授权
公开(公告)号：US5431897A
公开(公告)日：1995-07-11
申请号：US20223
申请日：1993-02-16
申请人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
发明人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
CPC分类号： A61K51/1063 , C07K16/3046 , A61K2039/505 , A61K2121/00 , C07K2317/24 , C07K2317/55 , Y10S436/808 , Y10S436/813 , Y10S530/808 , Y10S530/809 , Y10S530/837
摘要： This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the colorectal carcinoma lesion and which is labeled with an imaging agent under conditions so as to form a complex between the monoclonal antibody and the cell surface antigen, imaging any complex so formed, and thereby imaging the colorectal carcinoma lesion.This invention also provides a monoclonal antibody designated AS 33 (ATCC Accession No. HB 8779) and the hybridoma which produces it.
摘要翻译： 本发明提供了一种对人类患者的结肠直肠癌病变进行成像的方法，其包括向患者施用能够结合与结肠直肠癌病变相关的细胞表面抗原的单克隆抗体，并在成像剂的条件下进行标记， 在单克隆抗体和细胞表面抗原之间形成复合物，对如此形成的任何复合物进行成像，从而对结肠直肠癌病变进行成像。 本发明还提供了称为AS33（ATCC登录号HB 8779）和产生它的杂交瘤的单克隆抗体。
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公开(公告)号：US4562160A
公开(公告)日：1985-12-31
申请号：US482153
申请日：1983-04-01
申请人： Francisco X. Real , M. Jules Mattes , Alan N. Houghton , Philip O. Livingston , Kenneth O. Lloyd , Herbert F. Oettgen , Lloyd J. Old
发明人： Francisco X. Real , M. Jules Mattes , Alan N. Houghton , Philip O. Livingston , Kenneth O. Lloyd , Herbert F. Oettgen , Lloyd J. Old
IPC分类号： C07K16/30 , A61K39/395 , A61K39/44 , A61K43/00
CPC分类号： C07K16/3053 , Y10S435/948 , Y10S435/961 , Y10S436/804 , Y10S436/813 , Y10S436/815 , Y10S436/823 , Y10S530/806 , Y10S530/807 , Y10S530/828
摘要： The present invention concerns novel immunoprecipitating autologous antibodies which recognize the Class 1 gp90 antigen on melanoma cells. These antibodies, optionally tagged with a chromophoric or radioactive label and immobilized on an inert support, may be used to recognize and isolate the gp90 antigen from melanoma cell extracts. Monoclonal antibodies to melanoma may be screened with the gp90 antigen for those which recognize epitopes other than the FD antigenic system.The cell line containing the gp90 antigen which has been cultured in vitro is a source of gp90 antigen for generation of monoclonal antibodies which will be useful in analyzing the gp90 antigen for those epitopes which may be of diagnostic value in immunoassay of melanoma.
摘要翻译： 本发明涉及识别黑素瘤细胞上的1类gp90抗原的新型免疫沉淀自体抗体。 可以使用任选地标记有发色或放射性标记并固定在惰性载体上的这些抗体来识别和分离来自黑素瘤细胞提取物的gp90抗原。 可以用gp90抗原筛选黑素瘤单克隆抗体，以识别除FD抗原系统以外的表位。 含有体外培养的gp90抗原的细胞系是用于产生单克隆抗体的gp90抗原的来源，其可用于分析可能在黑素瘤免疫测定中具有诊断价值的那些表位的gp90抗原。
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5.发明授权Hybridoma cell lines which produce monoclonal antibodies having the properties of monoclonal antibody 100-310 and the monoclonal antibodies produced by these hybridoma cell lines 失效产生具有单克隆抗体100-310的特性的单克隆抗体的杂交瘤细胞系和由这些杂交瘤细胞系产生的单克隆抗体
公开(公告)号：US5565356A
公开(公告)日：1996-10-15
申请号：US273277
申请日：1994-07-11
申请人： Sydney Welt , Clarence Williams, Jr. , Elsje C. Barendswaard , Chaitanya R. Divgi , Pilar Garin-Chesa , Lloyd J. Old
发明人： Sydney Welt , Clarence Williams, Jr. , Elsje C. Barendswaard , Chaitanya R. Divgi , Pilar Garin-Chesa , Lloyd J. Old
CPC分类号： C07K16/3046 , A61K51/1063
摘要： Monoclonal antibody 100-310 is found to be reactive against colon cancer cells and would therefore be useful for diagnostic imaging and treatment of colon cancer.
摘要翻译： 发现单克隆抗体100-310对结肠癌细胞具有反应性，因此可用于结肠癌的诊断成像和治疗。
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6.发明授权
公开(公告)号：US4579827A
公开(公告)日：1986-04-01
申请号：US474415
申请日：1983-03-11
申请人： Junichi Sakamoto , Carlos Cordon-Cardo , Eileen Friedman , Connie L. Finstad , Warren E. Enker , Myron R. Melamed , Kenneth O. Lloyd , Herbert F. Oettgen , Lloyd J. Old
发明人： Junichi Sakamoto , Carlos Cordon-Cardo , Eileen Friedman , Connie L. Finstad , Warren E. Enker , Myron R. Melamed , Kenneth O. Lloyd , Herbert F. Oettgen , Lloyd J. Old
IPC分类号： G01N33/574 , A61K39/395 , C07K14/00 , C07K16/00 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/577 , C12N5/00 , C12N15/00
CPC分类号： C07K16/3046 , Y10S435/948 , Y10S435/96 , Y10S435/975 , Y10S436/808 , Y10S436/813 , Y10S530/864
摘要： A panel of monoclonal antibodies produced from human gastrointestinal tumors as immunogen is used to diagnose the presence of colon cancer. The antibody panel subsets the human gastrointestinal tract in its reactivity vis-a-vis esophagus, stomach, small intestine and colon. The panel is useful as a diagnostic probe for cancer.
摘要翻译： 使用由人类胃肠肿瘤作为免疫原产生的一组单克隆抗体来诊断结肠癌的存在。 抗体屏障使人胃肠道对食管，胃，小肠和结肠的反应性相对应。 该小组可用作癌症的诊断探针。
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公开(公告)号：US4935344A
公开(公告)日：1990-06-19
申请号：US837531
申请日：1986-03-07
申请人： Neil H. Bander , Carlos Cordon-Cardo , Connie L. Finstad , Willet F. Whitmore , Myron R. Melamed , Herbert F. Oettgen , Lloyd J. Old
发明人： Neil H. Bander , Carlos Cordon-Cardo , Connie L. Finstad , Willet F. Whitmore , Myron R. Melamed , Herbert F. Oettgen , Lloyd J. Old
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , Y10S436/817 , Y10S530/809 , Y10S530/864
摘要： Antigenic profiles of renal carcinoma specimans developed with panels of monoclonal antibodies derived from several different tissues serve as useful clinical indicators for cancer type, cancer subset as well as histiogenesis and prognosis indicators.
摘要翻译： 由几种不同组织衍生的单克隆抗体片段开发的肾癌标本的抗原谱，可作为癌症类型，癌症亚型以及组织发生和预后指标的有用临床指标。
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公开(公告)号：US4865998A
公开(公告)日：1989-09-12
申请号：US83723
申请日：1987-08-10
申请人： Hans-Joachim Feickert , Wolfgang Rettig , Karen Chorney , Carlos Cordon-Cardo , Myron R. Melamed , Kenneth O. Lloyd , Herbert F. Oettgen , Lloyd J. Old , Bernd Anger
发明人： Hans-Joachim Feickert , Wolfgang Rettig , Karen Chorney , Carlos Cordon-Cardo , Myron R. Melamed , Kenneth O. Lloyd , Herbert F. Oettgen , Lloyd J. Old , Bernd Anger
IPC分类号： C07K16/30 , G01N33/574
CPC分类号： C07K16/3023 , G01N33/57423 , Y10S435/948
摘要： A panel of monoclonal antibodies produced from normal human lung fibroblasts and human lung tumors as immunogen is used to diagnose the presence of lung tumors and differentiate between those which are benign and those which are cancerous.
摘要翻译： 使用由正常人肺成纤维细胞和人肺肿瘤作为免疫原产生的一组单克隆抗体来诊断肺肿瘤的存在并区分良性和癌性的那些。
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公开(公告)号：US4695538A
公开(公告)日：1987-09-22
申请号：US616397
申请日：1984-06-01
申请人： Richard J. Cote , Timothy M. Thomson , Alan N. Houghton , Herbert F. Oettgen , Lloyd J. Old , Carlos C. Cardo
发明人： Richard J. Cote , Timothy M. Thomson , Alan N. Houghton , Herbert F. Oettgen , Lloyd J. Old , Carlos C. Cardo
IPC分类号： G01N33/574 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C07K19/00 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/19 , G01N33/567 , G01N33/577 , G01N33/53
CPC分类号： G01N33/567 , C07K16/30 , Y10S435/96 , Y10S436/813 , Y10S436/828
摘要： Human monoclonal antibodies (HmAbs) capable of reacting with cell surface antigens and intracellular components are disclosed. It has been found that HmAbs Ev248, Ch-5, Ch-13, Te-39, Hu44, Ge-1, Gr-431, Gr169 and Sp909 may be used to detect these antigens in various cells. By means of these HmAbs malignant cells may be determined. This information may be used to screen metastasized tumors and primary tumors for tissue source and greatly affects the management of these cancers.
摘要翻译： 公开了能够与细胞表面抗原和胞内成分反应的人单克隆抗体（HmAb）。 已经发现HmAbs Ev248，Ch-5，Ch-13，Te-39，Hu44，Ge-1，Gr-431，Gr169和Sp909可用于检测各种细胞中的这些抗原。 通过这些HmAb可以确定恶性细胞。 该信息可用于筛选转移肿瘤和原发性肿瘤用于组织来源，并且极大地影响这些癌症的治疗。
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公开(公告)号：US4650756A
公开(公告)日：1987-03-17
申请号：US297814
申请日：1981-08-31
申请人： Lloyd J. Old , Kenneth O. Lloyd , Herbert F. Oettgen , Willet F. Whitmore , Jerzy Szkudlarek , Connie L. Finstad , Donna Morrissey , Shun-ichiro Ogata , Ryuzo Ueda
发明人： Lloyd J. Old , Kenneth O. Lloyd , Herbert F. Oettgen , Willet F. Whitmore , Jerzy Szkudlarek , Connie L. Finstad , Donna Morrissey , Shun-ichiro Ogata , Ryuzo Ueda
IPC分类号： C12N15/02 , A61K39/395 , C07K14/005 , C07K14/195 , C07K14/705 , C07K16/00 , C07K16/30 , C07K19/00 , C12N5/10 , C12P21/08 , C12P21/00 , C12N5/00 , C12N15/00 , C12R1/91
CPC分类号： C07K16/3038 , Y10S435/948 , Y10S530/808 , Y10S530/809 , Y10S530/864
摘要： The preparation and use of monoclonal antibodies to human renal tumor cells is described. The monoclonal antibodies bind to glycoproteins of 160Kd, 120Kd and 115Kd, a glycolipid, a HLA heavy chain, group A blood and group B blood antigens.
摘要翻译： 描述了对人肾肿瘤细胞的单克隆抗体的制备和使用。 单克隆抗体结合160Kd，120Kd和115Kd的糖蛋白，糖脂，HLA重链，A组血和B组血抗原。
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