公开(公告)号：US5160723A

公开(公告)日：1992-11-03

申请号：US671132

申请日：1991-03-18

申请人： Sydney Welt ,  Chaitanya R. Divgi ,  Samual Yeh ,  Lloyd J. Old ,  Herbert F. Oettgen ,  Francisco X. Real ,  Junichi Sakamoto

发明人： Sydney Welt ,  Chaitanya R. Divgi ,  Samual Yeh ,  Lloyd J. Old ,  Herbert F. Oettgen ,  Francisco X. Real ,  Junichi Sakamoto

IPC分类号： A61K51/10 ,  C07K16/30

CPC分类号： A61K51/1063 ,  C07K16/3046 ,  A61K2039/505 ,  A61K2121/00 ,  C07K2317/24 ,  C07K2317/55 ,  Y10S436/808 ,  Y10S436/813 ,  Y10S530/808 ,  Y10S530/809 ,  Y10S530/866

摘要： This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the coloretal carcinoma lesion and which is labeled with an imaging agent under conditions so as to form a complex between the monoclonal antibody and the cell surface antigen, imaging any complex so formed, and thereby imaging the colorectal carcinoma lesion.This invention also provides a monoclonal antibody designated AS 33 (ATCC Accession No. HB 8779) and the hybridoma which produces it.

摘要翻译： 本发明提供了一种在人类患者中对结肠直肠癌病变进行成像的方法，其包括向患者施用能够结合与该结肠癌病变相关的细胞表面抗原的单克隆抗体，并在成像剂的条件下进行标记， 在单克隆抗体和细胞表面抗原之间形成复合物，对如此形成的任何复合物进行成像，从而对结肠直肠癌病变进行成像。 本发明还提供了称为AS33（ATCC登录号HB 8779）和产生它的杂交瘤的单克隆抗体。

公开(公告)号：US5643550A

公开(公告)日：1997-07-01

申请号：US312633

申请日：1994-09-27

申请人： Sydney Welt ,  Chaitanya R. Divgi ,  Samual Yeh ,  Lloyd J. Old ,  Herbert F. Oettgen ,  Francisco X. Real ,  Junichi Sakamoto

发明人： Sydney Welt ,  Chaitanya R. Divgi ,  Samual Yeh ,  Lloyd J. Old ,  Herbert F. Oettgen ,  Francisco X. Real ,  Junichi Sakamoto

IPC分类号： A61K51/10 ,  C07K16/30 ,  A61K51/00 ,  A61K35/14 ,  A61K49/00

CPC分类号： A61K51/1063 ,  C07K16/3046 ,  A61K2039/505 ,  A61K2121/00 ,  C07K2317/24 ,  C07K2317/55 ,  Y10S436/808 ,  Y10S436/813 ,  Y10S530/808 ,  Y10S530/809 ,  Y10S530/837

摘要： This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the colorectal carcinoma lesion and which is labeled with an imaging agent under conditions so as to form a complex between the monoclonal antibody and the cell surface antigen, imaging any complex so formed, and thereby imaging the colorectal carcinoma lesion.This invention also provides a monoclonal antibody designated AS 33 (ATCC Accession No. HB 8779) and the hybridoma which produces it.

摘要翻译： 本发明提供了一种对人类患者的结肠直肠癌病变进行成像的方法，其包括向患者施用能够结合与结肠直肠癌病变相关的细胞表面抗原的单克隆抗体，并在成像剂的条件下进行标记， 在单克隆抗体和细胞表面抗原之间形成复合物，对如此形成的任何复合物进行成像，从而对结肠直肠癌病变进行成像。 本发明还提供了称为AS33（ATCC登录号HB 8779）和产生它的杂交瘤的单克隆抗体。

公开(公告)号：US5431897A

公开(公告)日：1995-07-11

申请号：US20223

申请日：1993-02-16

申请人： Sydney Welt ,  Chaitanya R. Divgi ,  Samual Yeh ,  Lloyd J. Old ,  Herbert F. Oettgen ,  Francisco X. Real ,  Junichi Sakamoto

发明人： Sydney Welt ,  Chaitanya R. Divgi ,  Samual Yeh ,  Lloyd J. Old ,  Herbert F. Oettgen ,  Francisco X. Real ,  Junichi Sakamoto

IPC分类号： A61K51/10 ,  C07K16/30 ,  A61K51/00 ,  A61K35/14 ,  A61K49/00 ,  G01N33/566

CPC分类号： A61K51/1063 ,  C07K16/3046 ,  A61K2039/505 ,  A61K2121/00 ,  C07K2317/24 ,  C07K2317/55 ,  Y10S436/808 ,  Y10S436/813 ,  Y10S530/808 ,  Y10S530/809 ,  Y10S530/837

摘要： This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the colorectal carcinoma lesion and which is labeled with an imaging agent under conditions so as to form a complex between the monoclonal antibody and the cell surface antigen, imaging any complex so formed, and thereby imaging the colorectal carcinoma lesion.This invention also provides a monoclonal antibody designated AS 33 (ATCC Accession No. HB 8779) and the hybridoma which produces it.

摘要翻译： 本发明提供了一种对人类患者的结肠直肠癌病变进行成像的方法，其包括向患者施用能够结合与结肠直肠癌病变相关的细胞表面抗原的单克隆抗体，并在成像剂的条件下进行标记， 在单克隆抗体和细胞表面抗原之间形成复合物，对如此形成的任何复合物进行成像，从而对结肠直肠癌病变进行成像。 本发明还提供了称为AS33（ATCC登录号HB 8779）和产生它的杂交瘤的单克隆抗体。

公开(公告)号：US4579827A

公开(公告)日：1986-04-01

申请号：US474415

申请日：1983-03-11

申请人： Junichi Sakamoto ,  Carlos Cordon-Cardo ,  Eileen Friedman ,  Connie L. Finstad ,  Warren E. Enker ,  Myron R. Melamed ,  Kenneth O. Lloyd ,  Herbert F. Oettgen ,  Lloyd J. Old

发明人： Junichi Sakamoto ,  Carlos Cordon-Cardo ,  Eileen Friedman ,  Connie L. Finstad ,  Warren E. Enker ,  Myron R. Melamed ,  Kenneth O. Lloyd ,  Herbert F. Oettgen ,  Lloyd J. Old

IPC分类号： G01N33/574 ,  A61K39/395 ,  C07K14/00 ,  C07K16/00 ,  C07K16/30 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  G01N33/577 ,  C12N5/00 ,  C12N15/00

CPC分类号： C07K16/3046 ,  Y10S435/948 ,  Y10S435/96 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/813 ,  Y10S530/864

摘要： A panel of monoclonal antibodies produced from human gastrointestinal tumors as immunogen is used to diagnose the presence of colon cancer. The antibody panel subsets the human gastrointestinal tract in its reactivity vis-a-vis esophagus, stomach, small intestine and colon. The panel is useful as a diagnostic probe for cancer.

摘要翻译： 使用由人类胃肠肿瘤作为免疫原产生的一组单克隆抗体来诊断结肠癌的存在。 抗体屏障使人胃肠道对食管，胃，小肠和结肠的反应性相对应。 该小组可用作癌症的诊断探针。

公开(公告)号：US08708086B2

公开(公告)日：2014-04-29

申请号：US13304913

申请日：2011-11-28

申请人： Hidenori Nagura ,  Junichi Sakamoto ,  Shingo Sugiyama

发明人： Hidenori Nagura ,  Junichi Sakamoto ,  Shingo Sugiyama

IPC分类号： B62K11/02 ,  B62D61/02

CPC分类号： B62K11/10 ,  B62K2202/00

摘要： A saddle-ride type vehicle in which the body frame can be reinforced without using a special reinforcing member includes left and right rear frame portions extending rearward and upward from a down frame. The right and left rear frame portions each include a rear frame front half portion and a rear frame rear half portion that are joined together at a joint. The left and right rear frame front half portions are connected to each other by a cross frame. The rear frame rear half portions extend further forward from its joint with the rear frame front half portion and are also joined together by the cross frame, which supports a seat through a storage box.

摘要翻译： 可以在不使用特殊加强构件的情况下加强车体框架的骑乘式车辆包括从下部框架向后和向上延伸的左后框架部分和右后框架部分。 右后框架部分和左后框架部分均包括在接头处接合在一起的后框架前半部分和后框架后半部分。 左右后框架前半部分通过十字框架相互连接。 后框架后半部分从其与后框架前半部分的接合部进一步向前延伸，并且还通过支架通过存放箱支撑的十字架连接在一起。

公开(公告)号：US06545009B1

公开(公告)日：2003-04-08

申请号：US09720644

申请日：2000-12-28

申请人： Yasuo Sugiyama ,  Yu Momose ,  Hiroyuki Kimura ,  Junichi Sakamoto ,  Hiroyuki Odaka

发明人： Yasuo Sugiyama ,  Yu Momose ,  Hiroyuki Kimura ,  Junichi Sakamoto ,  Hiroyuki Odaka

IPC分类号： A61K31435

CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D277/30 ,  C07D417/04

摘要： 1,3-Azole derivatives, pharmaceutical compositions thereof and methods for regulating the function of retinoid-related receptors with 1,3-azole derivatives are disclosed. Such regulation may be useful for preventing or treating diabetes, preventing or treating hyperlipidemia, preventing or treating impaired glucose tolerance (IGT) or for preventing transition from impaired glucose tolerance to diabetes.

摘要翻译： 公开了1,3-唑衍生物，其药物组合物和调节具有1,3-唑衍生物的类视黄醇相关受体功能的方法。 这种调节可用于预防或治疗糖尿病，预防或治疗高脂血症，预防或治疗葡萄糖耐量异常（IGT）或预防糖耐量受损转变为糖尿病。

公开(公告)号：US06454364B1

公开(公告)日：2002-09-24

申请号：US09928379

申请日：2001-08-14

申请人： Satoru Niwa ,  Michihito Shimada ,  Junichi Sakamoto

发明人： Satoru Niwa ,  Michihito Shimada ,  Junichi Sakamoto

IPC分类号： B60T866

CPC分类号： B60W20/13 ,  B60K6/44 ,  B60K6/52 ,  B60K6/543 ,  B60K17/354 ,  B60K17/356 ,  B60T8/00 ,  B60T8/267 ,  B60T13/662 ,  B60T2270/608 ,  B60W10/18 ,  B60W20/00 ,  B60W30/18127 ,  B60W2050/0002 ,  B60W2540/12 ,  B60W2720/106 ,  Y02T10/623 ,  Y02T10/6265 ,  Y10S903/916 ,  Y10S903/918 ,  Y10S903/947

摘要： A braking force control apparatus and method control a braking force of a motor vehicle that has (a) regenerative braking devices for front wheels and rear wheels, respectively, and (b) a friction braking device for each of the front wheels and the rear wheels. A target braking force of the front wheels and a target braking force of the rear wheels are calculated, based on a braking requirement made by a driver of the vehicle and a ratio of braking forces of the front wheels and the rear wheels. Initially, the regenerative braking devices are controlled to generate regenerative braking forces at the front wheels and the rear wheels, and then, if necessary, the friction braking device is controlled to generate a friction braking force at each of the front wheels and rear wheels, so that a total braking force applied to the front wheels and a total braking force applied to the rear wheels are controlled to the front-wheel target braking force and the rear-wheel target braking force, respectively.

公开(公告)号：US06342321B1

公开(公告)日：2002-01-29

申请号：US09467981

申请日：1999-12-21

申请人： Junichi Sakamoto ,  Nagato Osano ,  Tadanori Suto ,  Kenichi Iwata

发明人： Junichi Sakamoto ,  Nagato Osano ,  Tadanori Suto ,  Kenichi Iwata

IPC分类号： G02B520

CPC分类号： F26B5/045 ,  B05D3/0493 ,  G03F7/168

摘要： A method of drying a resinous composition layer, comprises the steps of coating a resinous composition over a substrate and drying the resinous composition layer to be dried. The drying method is a vacuum dry. And a drying condition in that case is such that an exhaustion is performed taking over 6 sec. till a degree of vacuum comes to 100 Torr.

摘要翻译： 干燥树脂组合物层的方法包括以下步骤：将树脂组合物涂布在基材上并干燥待干燥的树脂组合物层。 干燥方法是真空干燥。 在这种情况下，干燥条件使得耗尽超过6秒。 直到真空度达到100乇。

公开(公告)号：US06275647B1

公开(公告)日：2001-08-14

申请号：US09646714

申请日：2000-12-06

申请人： Hidehito Uemura ,  Masashi Omura ,  Junichi Sakamoto

发明人： Hidehito Uemura ,  Masashi Omura ,  Junichi Sakamoto

IPC分类号： H04N5928

CPC分类号： G11B5/588 ,  G11B5/0086 ,  G11B5/534 ,  G11B5/584 ,  G11B15/125 ,  G11B15/1875 ,  H04N5/78263 ,  H04N5/783 ,  H04N9/7921

摘要： In order to not only obtain excellent sound quality in a long-time recording mode not less than five times a standard recording mode by preventing, without narrowing a track pitch of a high-fidelity head, the high-fidelity head from tracing the third sound track from a target sound track as well as excellent picture quality free from crosstalk from an adjoining video track of a target video track but enable special playback without using a field memory in a video tape recorder, one head pair in conventional double azimuth type four heads for the standard recording mode and a threefold recording mode is used for video recording in the long-time recording mode and a head pair having a head width smaller than a width of a recording track is used exclusively for video playback in the long-time recording mode.

摘要翻译： 为了不仅在标准记录模式的5倍以上的长时间记录模式下，通过防止高保真磁头的轨道间距变窄，从而追踪第三声音不仅能获得优良的音质 来自目标声道的轨迹以及优良的图像质量，不受来自目标视频轨道的相邻视频轨道的串扰的影响，但是能够在磁带录像机中不使用场存储器进行特殊重放，在传统的双方位角型四磁头 对于标准记录模式，并且在长时间记录模式中使用三重记录模式进行视频记录，并且具有小于记录磁道的宽度的磁头宽度的磁头对专门用于长时间记录中的视频播放 模式。

公开(公告)号：US06231134B1

公开(公告)日：2001-05-15

申请号：US09123353

申请日：1998-07-28

申请人： Tsukasa Fukasawa ,  Akira Sakai ,  Hiroki Asada ,  Junichi Sakamoto ,  Shingo Urababa ,  Yoshinori Suzuki ,  Toshiyuki Sakai ,  Naoyasu Enomoto

发明人： Tsukasa Fukasawa ,  Akira Sakai ,  Hiroki Asada ,  Junichi Sakamoto ,  Shingo Urababa ,  Yoshinori Suzuki ,  Toshiyuki Sakai ,  Naoyasu Enomoto

IPC分类号： B60T864

CPC分类号： B60T8/4081 ,  B60L3/108 ,  B60L7/14 ,  B60L7/26 ,  B60L11/14 ,  B60L15/2009 ,  B60L2210/40 ,  B60L2240/423 ,  B60L2240/461 ,  B60T8/00 ,  B60T8/367 ,  B60T13/586 ,  B60T2270/602 ,  Y02T10/645 ,  Y02T10/70 ,  Y02T10/7077 ,  Y02T10/7241 ,  Y02T10/7275

摘要： A vehicle braking system including a frictional braking device for applying a frictional braking torque to each of a plurality of wheels of the vehicle, a regenerative braking device including at least one electric motor for applying a regenerative braking torque to at least one drive wheel of the vehicle, and a total braking torque control device for controlling a total braking torque including one or both of the regenerative braking torque and the frictional braking torque which are applied to each of the wheels. When the total braking torque of at least one of the wheels has exceeded an upper limit corresponding to a friction coefficient of a road surface on which the motor vehicle is running, the total braking torque control device operates to zero the regenerative braking torque of each of the above-indicated at least one wheel and control the frictional braking torque of this wheel while reducing an influence of the zeroing of the regenerative braking torque.

摘要翻译： 一种车辆制动系统，包括用于向车辆的多个车轮中的每一个车轮施加摩擦制动转矩的摩擦制动装置，包括至少一个电动机的再生制动装置，所述至少一个电动机用于将再生制动转矩施加到至少一个驱动轮的驱动轮 车辆，以及用于控制包括施加到每个车轮的再生制动转矩和摩擦制动转矩中的一个或两个的总制动转矩的总制动转矩控制装置。 当至少一个车轮的总制动转矩超过与机动车辆行驶的路面的摩擦系数相对应的上限时，总制动转矩控制装置动作以使每个车轮的再生制动转矩为零 上述至少一个车轮，并且在减小再生制动转矩归零的影响的同时控制该车轮的摩擦制动转矩。