公开(公告)号：US20220079571A1

公开(公告)日：2022-03-17

申请号：US17411489

申请日：2021-08-25

申请人： Synecor LLC

发明人： Richard S Stack ,  William L. Athas ,  Kevin W. Johnson

IPC分类号： A61B17/00 ,  A61F2/24 ,  A61M25/01

摘要： A system and method used to deliver an aortic valve therapeutic device, such as a delivery device for an aortic valve replacement, to an aortic valve site. The system includes a cable percutaneously introduced a cable into a vasculature of a patient and positioned to run from a femoral vein, through the heart via a transseptal puncture, and to a femoral artery. The therapeutic device is passed over an end of the cable at the venous side and is secured to the cable. The therapeutic device is pushed in a distal direction while the second end of the cable is pulled in the proximal direction to advance the therapeutic device to the mitral valve site. A left ventricle redirector aids in orienting the therapeutic device and preventing migration of the cable towards delicate mitral valve structures and chordae tendoneae during advancement of the therapeutic device.

公开(公告)号：US11135421B2

公开(公告)日：2021-10-05

申请号：US16578374

申请日：2019-09-22

申请人： Synecor LLC

发明人： Richard S Stack ,  William L Athas ,  Kevin Johnson ,  Emer M Feerick ,  Matthew Moran ,  Richard Phelan

IPC分类号： A61M1/10 ,  A61M1/12 ,  A61M60/857 ,  A61B17/34 ,  A61F2/24 ,  A61M25/09 ,  A61M60/135 ,  A61M60/148 ,  A61M25/10 ,  A61B17/00

摘要： A conduit for creating a passage from a right atrium to a left atrium, through a mitral valve into the left ventricle, and to provide a passage from the left ventricle into the aortic valve. The conduit includes an elongate tubular member having a shaft with a proximal section and a distal loop section at a distal end of the proximal section. The distal loop section includes a proximal curve, a distal curve, a generally straight segment extending between the curves, and a distal tip. The shaft in the distal loop section curves back on itself so that proximal curve is formed by a part of the shaft that is closer along the length of the shaft to the distal tip. The shapes of the proximal and distal curves are selected to direct the distal tip into the mitral valve after it has crossed the inter-atrial septum from the right atrium to the left atrium of the heart, and to orient the distal opening of the distal tip towards the aortic valve when the proximal curve is in the mitral valve and the distal tip is in the left ventricle.

公开(公告)号：US20210220131A1

公开(公告)日：2021-07-22

申请号：US17214899

申请日：2021-03-28

申请人： Synecor LLC

发明人： Richard S Stack ,  William L. Athas ,  Kevin W. Johnson

IPC分类号： A61F2/24 ,  A61B17/34

摘要： A method for delivering a therapeutic device to a target aortic valve site includes transseptally positioning a cable to run between afemoral vein, through the heart via the right atrium, left atrium, mitral valve, aortic valve and into the aorta and arterial vasculature with the flexible cable having a first end extending outside the body from a venous vessel and a second end external to the patient at the femoral artery. The aortic valve therapeutic device is advanced over the cable from outside the body and introduced into a femoral artery. A steerable sheath is advanced over the cable, into the venous vasculature and into the left ventricle of the heart. The aortic valve therapeutic device is pushed in a distal direction from the femoral artery to advance the aortic valve therapeutic device to the target site. The sheath protects surrounding tissues from the cable during movement of the therapeutic device through the vasculature, and is used to steer the therapeutic device from the front during final positioning to coaxially align the aortic valve therapeutic device at the target site while avoiding contact of the therapeutic device with the subvalvular conduction system.

公开(公告)号：US20200297485A1

公开(公告)日：2020-09-24

申请号：US16860015

申请日：2020-04-27

申请人： SYNECOR LLC

发明人： Richard S Stack

IPC分类号： A61F2/24 ,  A61M25/01

摘要： A method for delivering a therapeutic device to a target aortic valve site includes transseptally positioning a cable to run between a femoral artery, through the heart via an aortic valve, left ventricle, mitral valve, left atrium, and right atrium into the venous vasculature, the flexible member having a first end extending outside the body from a venous vessel superior to the heart and a second end external to the patient at the femoral artery. The aortic valve therapeutic device is attached to the cable outside the body and introduced into a femoral artery. A steerable sheath is advanced over the cable, into the venous vasculature and into the left ventricle of the heart. The aortic valve therapeutic device is pushed in a distal direction from the femoral artery while the cable is pulled from the venous vessel to advance the aortic valve therapeutic device to the target site. The sheath protects surrounding tissues from the cable during movement of the therapeutic device through the vasculature, and may be steered during final positioning to align the aortic valve therapeutic device at the target site.

公开(公告)号：US09126048B2

公开(公告)日：2015-09-08

申请号：US14064544

申请日：2013-10-28

申请人： Synecor LLC

发明人： Terrance J Ransbury ,  William E Sanders ,  Richard S Stack ,  Colleen Stack

IPC分类号： A61N1/00 ,  A61N1/362 ,  A61N1/05 ,  A61N1/36 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/024 ,  A61M25/00 ,  A61M25/01 ,  A61M25/04

CPC分类号： A61N1/3621 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/024 ,  A61M25/0074 ,  A61M25/0125 ,  A61M25/0147 ,  A61M25/04 ,  A61M2025/0175 ,  A61N1/056 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/3627

摘要： A neuromodulation system for treating acute heart failure syndromes includes a first catheter having a parasympathetic therapy element adapted for positioning within a first blood vessel such as a superior vena cava, and a second catheter sympathetic therapy element adapted for positioning with a second, different, blood vessel such as the pulmonary artery. The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a Swan-Ganz catheter positionable within a pulmonary artery, such that the Swan-Ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy. The parasympathetic therapy element is energized to deliver neuromodulation therapy to a parasympathetic nerve fiber such as a vagus nerve, while the sympathetic therapy element is energized to deliver neuromodulation therapy to a sympathetic nerve fiber such as a sympathetic cardiac nerve fiber. For treatment of acute heart failure syndromes, the neuromodulation therapy may be used to lower heart rate and increase cardiac inotropy.

摘要翻译： 用于治疗急性心力衰竭综合征的神经调节系统包括具有适于定位在诸如上腔静脉的第一血管内的副交感神经治疗元件的第一导管和适于用第二不同血液定位的第二导管交感神经治疗元件 血管如肺动脉。 导管包括其中一个导管可滑动地布置在另一个导管上的系统。 该系统还可以可滑动地设置在第三细长元件（例如可定位在肺动脉内的Swan-Ganz导管）之间，使得Swan-Ganz可用于监测神经调节治疗期间的血压和心输出量等参数。 副交感神经治疗元件被激励以将神经调节治疗递送到副交感神经纤维例如迷走神经，而交感神经治疗元件通电以将神经调节治疗递送至交感神经纤维如交感神经纤维。 对于急性心力衰竭综合征的治疗，神经调节治疗可用于降低心率并增加心脏内向性。

公开(公告)号：US11364377B2

公开(公告)日：2022-06-21

申请号：US16578379

申请日：2019-09-22

申请人： Synecor LLC

发明人： Richard S Stack ,  William L Athas ,  Kevin Johnson ,  Emer M Feerick ,  Matthew Moran ,  Damian Muldoon ,  Liam Ruddy

IPC分类号： A61M60/857 ,  A61B17/34 ,  A61F2/24 ,  A61M25/09 ,  A61M60/135 ,  A61M60/148 ,  A61M25/10 ,  A61B17/00

摘要： An instrument for facilitating transseptal delivery of a cardiac therapeutic device is positionable in a left ventricle. The instrument includes an elongate shaft having a tubular lumen, the shaft having a proximal portion and a distal portion actively steerable between a generally straight position and a curved position. An external pull wire and an internal pull wire are each actuatable to move the distal portion to the curved position. The external pull wire extends internally through the proximal portion of the shaft and longitudinally along the exterior of the distal portion of the shaft, while the internal pull wire extends internally through the proximal portion of the shaft adjacent to the external pull wire, and extends internally through the distal portion of the shaft.

公开(公告)号：US11000637B2

公开(公告)日：2021-05-11

申请号：US16578373

申请日：2019-09-22

申请人： Synecor LLC

发明人： Richard S Stack ,  William L Athas ,  Kevin Johnson ,  Emer M Feerick ,  Matthew Moran ,  Damian Muldoon ,  Liam Ruddy ,  William Cannon ,  Rory O'Brien

IPC分类号： A61M1/12 ,  A61M25/09 ,  A61M1/10 ,  A61B17/34 ,  A61F2/24 ,  A61M25/10 ,  A61B17/00

摘要： A system and method used to deliver a percutaneous ventricular assist device (pVAD) or other cardiac therapeutic device to a site within the heart, such as a site at the aortic valve. A flexible device is percutaneously introduced into a vasculature of a patient and positioned to run from a femoral vein, through the heart via a transseptal puncture, and to a femoral artery. The venous-side end of the flexible device is withdrawn out the venous vasculature superior to the heart, and a pVAD is secured to the flexible device. The pVAD is pushed in a distal direction while the arterial-side end of the flexible device is pulled in the proximal direction to advance the pVAD to the target site. A left ventricle redirector aids in orienting the pVAD and preventing migration of the flexible member towards delicate structures of the heart during advancement of the pVAD.

公开(公告)号：US20210085851A1

公开(公告)日：2021-03-25

申请号：US16579779

申请日：2019-09-23

申请人： Synecor LLC

发明人： Richard S Stack ,  William L Athas ,  Kevin Johnson ,  Salvatore Castro

IPC分类号： A61M1/12

摘要： A system and method for extracting a pVAD device that is implanted with a distal portion in an aorta of the heart and a drive line extending across an inter-atrial septum and out of the body via a superior vessel of the venous vasculature, include a first device that is introduced into a femoral artery and through the descending aorta used to engage a distal part of the pVAD device in the aorta of a patient using an instrument. A second, cutter, device is introduced into the venous vasculature superior to heart, advanced to a position adjacent the inter-atrial septum, and used to cut the pVAD drive line adjacent to the inter-atrial septum. After cutting, a first portion of the pVAD is withdrawn from the body via the venous vasculature, and a second portion is withdrawn from the body via the femoral artery.

公开(公告)号：US20140052208A1

公开(公告)日：2014-02-20

申请号：US14064544

申请日：2013-10-28

申请人： Synecor LLC

发明人： Terrance J Ransbury ,  William E Sanders ,  Richard S Stack ,  Colleen Stack

IPC分类号： A61N1/362 ,  A61N1/05

CPC分类号： A61N1/3621 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/024 ,  A61M25/0074 ,  A61M25/0125 ,  A61M25/0147 ,  A61M25/04 ,  A61M2025/0175 ,  A61N1/056 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/3627

摘要： A neuromodulation system for treating acute heart failure syndromes includes a first catheter having a parasympathetic therapy element adapted for positioning within a first blood vessel such as a superior vena cava, and a second catheter sympathetic therapy element adapted for positioning with a second, different, blood vessel such as the pulmonary artery. The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a Swan-Ganz catheter positionable within a pulmonary artery, such that the Swan-Ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy. The parasympathetic therapy element is energized to deliver neuromodulation therapy to a parasympathetic nerve fiber such as a vagus nerve, while the sympathetic therapy element is energized to deliver neuromodulation therapy to a sympathetic nerve fiber such as a sympathetic cardiac nerve fiber. For treatment of acute heart failure syndromes, the neuromodulation therapy may be used to lower heart rate and increase cardiac inotropy.

摘要翻译： 用于治疗急性心力衰竭综合征的神经调节系统包括具有适于定位在诸如上腔静脉的第一血管内的副交感神经治疗元件的第一导管和适于用第二不同血液定位的第二导管交感神经治疗元件 血管如肺动脉。 导管包括其中一个导管可滑动地布置在另一个导管上的系统。 该系统还可以可滑动地设置在第三细长元件（例如可定位在肺动脉内的Swan-Ganz导管）之间，使得Swan-Ganz可用于监测神经调节治疗期间的血压和心输出量等参数。 副交感神经治疗元件被激励以将神经调节治疗递送到副交感神经纤维例如迷走神经，而交感神经治疗元件通电以将神经调节治疗递送至交感神经纤维如交感神经纤维。 对于急性心力衰竭综合征的治疗，神经调节治疗可用于降低心率并增加心脏内向性。

公开(公告)号：US20210177389A1

公开(公告)日：2021-06-17

申请号：US17188936

申请日：2021-03-01

申请人： Synecor LLC

发明人： Richard S Stack ,  William L Athas ,  Kevin W Johnson

IPC分类号： A61B17/00 ,  A61M25/01 ,  A61M25/10

摘要： A system and method used to deliver a valve delivery system carrying a valve to a target valve annulus in the heart includes a cable percutaneously introduced into a vasculature of a patient and positioned to run from a femoral vein, transseptally through the heart, to a femoral artery. The valve delivery system device is passed over an end of the cable at the arterial side and is secured to the cable. The valve delivery system device is pushed in a distal direction while the venous end of the cable is pulled in the proximal direction, to advance the valve delivery system to the target valve annulus. A left ventricle redirector positionable on the cable from the venous end has a distal end actively steered during advancement and positioning of the valve delivery device, exerting forces that steer the distal nose of the valve delivery device as it moves towards the valve annulus.