公开(公告)号：US20200375969A1

公开(公告)日：2020-12-03

申请号：US16497967

申请日：2018-03-26

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Jason Green ,  Maria Hopkins ,  Benjamin Jones ,  Andre A. Kiryanov ,  Jon Kuehler ,  Holger Monenschein ,  Sean Murphy ,  Thomas Nixey ,  Huikai Sun

IPC: A61K31/4545 ,  A61K31/198 ,  A61K31/454 ,  A61K31/451 ,  A61K31/506 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/553 ,  A61K31/4535 ,  A61K31/519 ,  A61K31/501 ,  A61K31/5365 ,  C07D401/12 ,  C07D211/52 ,  C07D401/14 ,  C07D405/12 ,  C07D498/04 ,  C07D413/12 ,  C07D409/12 ,  C07D487/04 ,  C07D417/12

Abstract: Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R4, R5, R8, R10, R11, X1, X2, X3, X9, X12, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.

公开(公告)号：US11426397B2

公开(公告)日：2022-08-30

申请号：US16497967

申请日：2018-03-26

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Jason Green ,  Maria Hopkins ,  Benjamin Jones ,  Andre A. Kiryanov ,  Jon Kuehler ,  Holger Monenschein ,  Sean Murphy ,  Thomas Nixey ,  Huikai Sun

IPC: C07D417/12 ,  A61K31/4545 ,  A61K31/198 ,  A61K31/451 ,  A61K31/4525 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/553 ,  C07D211/52 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D487/04 ,  C07D498/04

Abstract: Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R4, R5, R8, R10, R11, X1, X2, X3, X9, X12, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.