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公开(公告)号：US20180186772A1
公开(公告)日：2018-07-05
申请号：US15909801
申请日：2018-03-01
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Jason W. Brown , Melinda Davis , Anthony Ivetac , Benjamin Jones , Andre A. Kiryanov , Jon Kuehler , Marion Lanier , Joanne Miura , Sean Murphy , Xiaolun Wang
IPC: C07D401/14 , A61K31/496 , C07D487/06 , A61K31/4985 , A61K31/5513 , C07D491/107 , C07D405/14 , C07D471/08 , C07D401/04 , A61K31/4545 , C07D487/10 , A61K31/444 , A61K31/551 , C07D491/10 , A61K31/5377 , C07D417/14 , C07D413/14 , C07D487/04
CPC classification number: C07D401/14 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/551 , A61K31/5513 , C07D401/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D487/04 , C07D487/06 , C07D487/10 , C07D491/10 , C07D491/107
Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.
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公开(公告)号：US09944626B2
公开(公告)日：2018-04-17
申请号：US15620620
申请日：2017-06-12
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Jason W. Brown , Melinda Davis , Anthony Ivetac , Benjamin Jones , Andre A. Kiryanov , Jon Kuehler , Marion Lanier , Joanne Miura , Sean Murphy , Xiaolun Wang
IPC: C07D413/14 , A61K31/5377 , C07D401/14 , C07D487/06 , C07D417/14 , C07D491/10 , A61K31/551 , A61K31/444 , C07D487/10 , A61K31/4545 , C07D401/04 , C07D471/08 , C07D405/14 , C07D491/107 , A61K31/5513 , A61K31/4985 , C07D487/04 , A61K31/496
CPC classification number: C07D401/14 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/551 , A61K31/5513 , C07D401/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D487/04 , C07D487/06 , C07D487/10 , C07D491/10 , C07D491/107
Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.
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公开(公告)号：US20170275271A1
公开(公告)日：2017-09-28
申请号：US15620620
申请日：2017-06-12
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Jason W. Brown , Melinda Davis , Anthony Ivetac , Benjamin Jones , Andre A. Kiryanov , Jon Kuehler , Marion Lanier , Joanne Miura , Sean Murphy , Xiaolun Wang
IPC: C07D401/14 , A61K31/496 , C07D417/14 , A61K31/5377 , C07D491/10 , A61K31/551 , A61K31/444 , C07D487/10 , A61K31/4545 , C07D401/04 , C07D471/08 , C07D405/14 , C07D491/107 , A61K31/5513 , A61K31/4985 , C07D487/04 , C07D487/06 , C07D413/14
CPC classification number: C07D401/14 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/551 , A61K31/5513 , C07D401/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D487/04 , C07D487/06 , C07D487/10 , C07D491/10 , C07D491/107
Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.
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公开(公告)号：US20160251337A1
公开(公告)日：2016-09-01
申请号：US15150976
申请日：2016-05-10
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Jason W. Brown , Melinda Davis , Anthony Ivetac , Benjamin Jones , Andre A. Kiryanov , Jon Kuehler , Marion Lanier , Joanne Miura , Sean Murphy , Xiaolun Wang
IPC: C07D401/14 , C07D413/14 , C07D401/04 , C07D471/08 , C07D491/107 , C07D487/04 , C07D487/10 , C07D405/14 , C07D417/14
CPC classification number: C07D401/14 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/551 , A61K31/5513 , C07D401/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D487/04 , C07D487/06 , C07D487/10 , C07D491/10 , C07D491/107
Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.
Abstract translation: 本发明提供下式的化合物：其可用作PHD的抑制剂，其药物组合物，用于治疗与HIF相关的病症的方法，用于制备化合物的方法及其中间体。
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公开(公告)号：US09345713B2
公开(公告)日：2016-05-24
申请号：US14693110
申请日：2015-04-22
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Jason W. Brown , Melinda Davis , Anthony Ivetac , Benjamin Jones , Andre A. Kiryanov , Jon Kuehler , Marion Lanier , Joanne Miura , Sean Murphy , Xiaolun Wang
IPC: A61K31/496 , A61K31/551 , A61K31/5513 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D491/107 , C07D417/14 , C07D471/08 , C07D487/06 , C07D487/10 , C07D491/10 , A61K31/444 , A61K31/4545 , A61K31/4985 , A61K31/5377
CPC classification number: C07D401/14 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/551 , A61K31/5513 , C07D401/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D487/04 , C07D487/06 , C07D487/10 , C07D491/10 , C07D491/107
Abstract: The present invention provides a method of treating acute heart failure by administering a compound of the formula: or a pharmaceutically acceptable salt thereof.
Abstract translation: 本发明提供了通过给予下式化合物或其药学上可接受的盐治疗急性心力衰竭的方法。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20200375969A1
公开(公告)日：2020-12-03
申请号：US16497967
申请日：2018-03-26
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Jason Green , Maria Hopkins , Benjamin Jones , Andre A. Kiryanov , Jon Kuehler , Holger Monenschein , Sean Murphy , Thomas Nixey , Huikai Sun
IPC: A61K31/4545 , A61K31/198 , A61K31/454 , A61K31/451 , A61K31/506 , A61K31/4525 , A61K31/496 , A61K31/553 , A61K31/4535 , A61K31/519 , A61K31/501 , A61K31/5365 , C07D401/12 , C07D211/52 , C07D401/14 , C07D405/12 , C07D498/04 , C07D413/12 , C07D409/12 , C07D487/04 , C07D417/12
Abstract: Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R4, R5, R8, R10, R11, X1, X2, X3, X9, X12, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.
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公开(公告)号：US09708296B2
公开(公告)日：2017-07-18
申请号：US15150976
申请日：2016-05-10
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Jason W. Brown , Melinda Davis , Anthony Ivetac , Benjamin Jones , Andre A. Kiryanov , Jon Kuehler , Marion Lanier , Joanne Miura , Sean Murphy , Xiaolun Wang
IPC: C07D401/14 , C07D405/14 , C07D413/14 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/5377 , A61K31/496 , A61K31/551 , C07D401/04 , C07D491/107 , C07D417/14 , C07D471/08 , C07D487/06 , C07D487/10 , C07D491/10 , A61K31/4545 , A61K31/4985 , A61K31/5513 , C07D487/04
CPC classification number: C07D401/14 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/551 , A61K31/5513 , C07D401/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D487/04 , C07D487/06 , C07D487/10 , C07D491/10 , C07D491/107
Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.
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![Substituted pyrido[2,3-b]pyrazines](/abs-image/US/2014/09/02/US08822470B2/abs.jpg.150x150.jpg)
公开(公告)号：US08822470B2
公开(公告)日：2014-09-02
申请号：US13889585
申请日：2013-05-08
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Anthony R. Gangloff , Andrew John Jennings , Benjamin Jones , Andre A. Kiryanov
IPC: A61K31/4985 , C07D471/04
CPC classification number: C07D513/14 , A61K31/4985 , A61K31/506 , A61K31/53 , A61K31/5383 , A61K31/542 , A61K31/5517 , A61K31/635 , A61K45/06 , C07D471/04 , C07D471/14 , C07D498/14
Abstract: Disclosed are compounds of the following formula: in which R1, R2, R3, R4, R5, R6, R7, and X, are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
Abstract translation: 公开了下列化学式：其中R1，R2，R3，R4，R5，R6，R7和X在本说明书中定义。 还公开了含有可用于制备化合物的化合物，方法和中间体的药物组合物，试剂盒和制品，以及使用该化合物治疗与PARP活性相关的疾病，病症和病症的方法。
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9.发明授权公开(公告)号：US11426397B2
公开(公告)日：2022-08-30
申请号：US16497967
申请日：2018-03-26
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Jason Green , Maria Hopkins , Benjamin Jones , Andre A. Kiryanov , Jon Kuehler , Holger Monenschein , Sean Murphy , Thomas Nixey , Huikai Sun
IPC: C07D417/12 , A61K31/4545 , A61K31/198 , A61K31/451 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5365 , A61K31/553 , C07D211/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/04 , C07D498/04
Abstract: Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R4, R5, R8, R10, R11, X1, X2, X3, X9, X12, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.
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公开(公告)号：US10407409B2
公开(公告)日：2019-09-10
申请号：US15909801
申请日：2018-03-01
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Jason W. Brown , Melinda Davis , Anthony Ivetac , Benjamin Jones , Andre A. Kiryanov , Jon Kuehler , Marion Lanier , Joanne Miura , Sean Murphy , Xiaolun Wang
IPC: C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/4439 , A61K31/4545 , A61K31/5377 , A61K31/496 , A61K31/551 , C07D491/107 , C07D471/08 , C07D487/06 , C07D487/10 , C07D491/10 , A61K31/444 , A61K31/4985 , A61K31/5513 , C07D487/04
Abstract: The present invention provides compounds of the formula: which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.
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